Mapping and significance of the mRNA methylome

The Mouse Cytosine-5 RNA Methyltransferase NSun2 Is a Component of the Chromatoid Body and Required for Testis Differentiation

(2013) S. Hussain et al.   MOLECULAR AND CELLULAR BIOLOGY

Role for the obesity-related FTO gene in the cellular sensing of amino acids

(2013) P. Gulati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N6-methyl-adenosine modification in messenger and long non-coding RNA

(2013) Tao Pan   TRENDS IN BIOCHEMICAL SCIENCES

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

(2013) Fiona McMurray et al.   PLoS Genetics

Mutation in NSUN2, which Encodes an RNA Methyltransferase, Causes Autosomal-Recessive Intellectual Disability

(2012) Muzammil Ahmad Khan et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in NSUN2 Cause Autosomal- Recessive Intellectual Disability

(2012) Lia Abbasi-Moheb et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mapping the tRNA Binding Site on the Surface of Human DNMT2 Methyltransferase

(2012) Tomasz P. Jurkowski et al.   BIOCHEMISTRY

Identification of Methylated Proteins in the Yeast Small Ribosomal Subunit: A Role for SPOUT Methyltransferases in Protein Arginine Methylation

(2012) Brian D. Young et al.   BIOCHEMISTRY

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

From Mice to Humans

(2012) Fiona McMurray et al.   Current Diabetes Reports

Genetics of Obesity: What have we Learned?

(2012) Helene Choquet et al.   CURRENT GENOMICS

FTO, RNA epigenetics and epilepsy

(2012) Joie Rowles et al.   Epigenetics

Whole exome sequencing identifies a splicing mutation inNSUN2as a cause of a Dubowitz-like syndrome

(2012) Fernando Jose Martinez et al.   JOURNAL OF MEDICAL GENETICS

FTO and Obesity: A Problem for a Billion People

(2012) Giles S. H. Yeo   JOURNAL OF NEUROENDOCRINOLOGY

Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

(2012) Baoen Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis

(2012) Francesca Tuorto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA

(2012) Jeffrey E. Squires et al.   NUCLEIC ACIDS RESEARCH

The human tRNA m5C methyltransferase Misu is multisite-specific

(2012) Sylvie Auxilien et al.   RNA Biology

Reversible RNA adenosine methylation in biological regulation

(2012) Guifang Jia et al.   TRENDS IN GENETICS

The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3′-untranslated region of p16

(2012) Xiaotian Zhang et al.   Nature Communications

RNA Methylation by the MIS Complex Regulates a Cell Fate Decision in Yeast

(2012) Sudeep D. Agarwala et al.   PLoS Genetics

Adenosine Methylation in Arabidopsis mRNA is Associated with the 3′ End and Reduced Levels Cause Developmental Defects

(2012) Zsuzsanna Bodi et al.   Frontiers in Plant Science

Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions

(2012) Yoichiro Sugimoto et al.   GENOME BIOLOGY

The birth of the Epitranscriptome: deciphering the function of RNA modifications

(2012) Yogesh Saletore et al.   GENOME BIOLOGY

Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers

(2011) Mayumi Okamoto et al.   DNA AND CELL BIOLOGY

The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress

(2011) Devi Thiagarajan et al.   Epigenetics

New families of human regulatory RNA structures identified by comparative analysis of vertebrate genomes

(2011) B. J. Parker et al.   GENOME RESEARCH

Depressive disorder moderates the effect of the FTO gene on body mass index

(2011) M Rivera et al.   MOLECULAR PSYCHIATRY

Converting nonsense codons into sense codons by targeted pseudouridylation

(2011) John Karijolich et al.   NATURE

Deep sequencing reveals 50 novel genes for recessive cognitive disorders

(2011) Hossein Najmabadi et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

2′-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family

(2011) Maria Werner et al.   NUCLEIC ACIDS RESEARCH

Comprehensive Structural and Substrate Specificity Classification of the Saccharomyces cerevisiae Methyltransferome

(2011) Tomasz Wlodarski et al.   PLoS One

On the Evolutionary Origin of Eukaryotic DNA Methyltransferases and Dnmt2

(2011) Tomasz P. Jurkowski et al.   PLoS One

Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis

(2011) C. F. Hongay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel synthesis and detection method for cap-associated adenosine modifications in mouse mRNA

(2011) Susanne Kruse et al.   Scientific Reports

The RNA–Methyltransferase Misu (NSun2) Poises Epidermal Stem Cells to Differentiate

(2011) Sandra Blanco et al.   PLoS Genetics

RNA nucleotide methylation

(2011) Yuri Motorin et al.   Wiley Interdisciplinary Reviews-RNA

Piecing together the FTO jigsaw

(2011) Timothy M Frayling et al.   GENOME BIOLOGY

FTO Biology and Obesity: Why Do a Billion of Us Weigh 3 kg More?

(2011) Man-Ka Marcella Cheung et al.   Frontiers in Endocrinology

An alignment algorithm for bisulfite sequencing using the Applied Biosystems SOLiD System

(2010) Brian D. Ondov et al.   BIOINFORMATICS

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage

(2010) M. Schaefer et al.   GENES & DEVELOPMENT

Characterization of hMTr1, a Human Cap1 2′-O-Ribose Methyltransferase

(2010) François Bélanger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncovering the Human Methyltransferasome

(2010) Tanya C. Petrossian et al.   MOLECULAR & CELLULAR PROTEOMICS

Crystal structure of the FTO protein reveals basis for its substrate specificity

(2010) Zhifu Han et al.   NATURE

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications

(2010) R Alan Harris et al.   NATURE BIOTECHNOLOGY

Grand Challenge Commentary: RNA epigenetics?

(2010) Chuan He   Nature Chemical Biology

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Yeast targets for mRNA methylation

(2010) Zsuzsanna Bodi et al.   NUCLEIC ACIDS RESEARCH

The RNA modification database, RNAMDB: 2011 update

(2010) W. A. Cantara et al.   NUCLEIC ACIDS RESEARCH

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly

(2010) A. J. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Where to go with FTO?

(2010) Rachel Larder et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The genetics of obesity: FTO leads the way

(2010) Katherine A. Fawcett et al.   TRENDS IN GENETICS

Function and detection of 5-methylcytosine in eukaryotic RNA

(2010) Jeffrey E Squires et al.   Epigenomics

A New Nuclear Function of the Entamoeba histolytica Glycolytic Enzyme Enolase: The Metabolic Regulation of Cytosine-5 Methyltransferase 2 (Dnmt2) Activity

(2010) Ayala Tovy et al.   PLoS Pathogens

Substitutional A-to-I RNA editing

(2010) Bjorn-Erik Wulff et al.   Wiley Interdisciplinary Reviews-RNA

Cap and cap-binding proteins in the control of gene expression

(2010) Ivan Topisirovic et al.   Wiley Interdisciplinary Reviews-RNA

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

(2009) M. Schaefer et al.   CANCER RESEARCH

Solving the Dnmt2 enigma

(2009) Matthias Schaefer et al.   CHROMOSOMA

Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases

(2009) Athanasia Pavlopoulou et al.   GENOMICS

The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability

(2009) Shobbir Hussain et al.   JOURNAL OF CELL BIOLOGY

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

5-methylcytosine in RNA: detection, enzymatic formation and biological functions

(2009) Yuri Motorin et al.   NUCLEIC ACIDS RESEARCH

Genome-wide DNA methylation profiling

(2009) Marina Bibikova et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain

(2008) Robert Fredriksson et al.   ENDOCRINOLOGY

Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO

(2008) Guifang Jia et al.   FEBS LETTERS

Crystal Structure of the Escherichia coli 23S rRNA:m5C Methyltransferase RlmI (YccW) Reveals Evolutionary Links between RNA Modification Enzymes

(2008) S. Sunita et al.   JOURNAL OF MOLECULAR BIOLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

RNA cytosine methylation analysis by bisulfite sequencing

(2008) M. Schaefer et al.   NUCLEIC ACIDS RESEARCH

MTA Is an Arabidopsis Messenger RNA Adenosine Methylase and Interacts with a Homolog of a Sex-Specific Splicing Factor

(2008) S. Zhong et al.   PLANT CELL

The Drosophila Cytosine-5 Methyltransferase Dnmt2 Is Associated with the Nuclear Matrix and Can Access DNA during Mitosis

(2008) Matthias Schaefer et al.   PLoS One

Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism

(2008) T. P. Jurkowski et al.   RNA