Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

ALIX- and ESCRT-III–dependent sorting of tetraspanins to exosomes

(2020) Jorge Larios et al.   JOURNAL OF CELL BIOLOGY

The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

(2020) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy

(2019) Devesh C. Pant et al.   JOURNAL OF CLINICAL INVESTIGATION

DEGS1-associated aberrant sphingolipid metabolism impairs nervous system function in humans

(2019) Gergely Karsai et al.   JOURNAL OF CLINICAL INVESTIGATION

DEGS1 variant causes neurological disorder

(2019) Vadim Dolgin et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype

(2018) Georgia Minakaki et al.   Autophagy

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

(2018) André M. Miranda et al.   Nature Communications

Sphingolipids and lipid rafts: Novel concepts and methods of analysis

(2018) Erhard Bieberich   CHEMISTRY AND PHYSICS OF LIPIDS

Lipidomic profiling of extracellular vesicles derived from prostate and prostate cancer cell lines

(2018) Joshua S. Brzozowski et al.   Lipids in Health and Disease

Emerging Roles of Air Gases in Lipid Bilayers

(2018) Chia-Wei Lee et al.   Small

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line

(2016) Maria Podbielska et al.   JOURNAL OF LIPID RESEARCH

ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

(2016) Carolina Villarroya-Beltri et al.   Nature Communications

ATG12–ATG3 interacts with Alix to promote basal autophagic flux and late endosome function

(2015) Lyndsay Murrow et al.   NATURE CELL BIOLOGY

Extracellular vesicles from bone marrow mesenchymal stem/stromal cells transport tumor regulatory microRNA, proteins, and metabolites

(2015) Krishna C. Vallabhaneni et al.   Oncotarget

Producing human ceramide-NS by metabolic engineering using yeast Saccharomyces cerevisiae

(2015) Suguru Murakami et al.   Scientific Reports

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

(2014) Anne-Maria Poehler et al.   Autophagy

Increased Dihydroceramide/Ceramide Ratio Mediated by Defective Expression ofdegs1Impairs Adipocyte Differentiation and Function

(2014) Nuria Barbarroja et al.   DIABETES

Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation

(2014) Manuel Alonso Y Adell et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

(2013) Taketoshi Kajimoto et al.   Nature Communications

Cardiomyocyte Specific Deficiency of Serine Palmitoyltransferase Subunit 2 Reduces Ceramide but Leads to Cardiac Dysfunction

(2012) Su-Yeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation

(2010) David Teis et al.   EMBO JOURNAL

Characterization of a dorsal-eye Gal4 Line inDrosophila

(2010) Clayton M. Morrison et al.   GENESIS

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

N-Myristoylation targets dihydroceramide Δ4-desaturase 1 to mitochondria: Partial involvement in the apoptotic effect of myristic acid

(2009) Erwan Beauchamp et al.   BIOCHIMIE

A fluorescent sphingolipid binding domain peptide probe interacts with sphingolipids and cholesterol-dependent raft domains

(2008) Sarita Hebbar et al.   JOURNAL OF LIPID RESEARCH

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE