Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson’s disease before brain pathology

NLRP3 inflammasome in cardiovascular diseases: Pathophysiological and pharmacological implications

(2021) Carolina Pellegrini et al.   MEDICINAL RESEARCH REVIEWS

Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels

(2021) Xinyi Huang et al.   Biology-Basel

NLRP3 at the crossroads between immune/inflammatory responses and enteric neuroplastic remodeling in a mouse model of diet‐induced obesity

(2021) Carolina Pellegrini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Colonic dysmotility associated with high‐fat diet‐induced obesity: Role of enteric glia

(2020) Luca Antonioli et al.   FASEB JOURNAL

Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition

(2020) Carolina Pellegrini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microbiota-gut-brain axis in health and disease: Is NLRP3 inflammasome at the crossroads of microbiota-gut-brain communications?

(2020) Carolina Pellegrini et al.   PROGRESS IN NEUROBIOLOGY

Intestinal epithelial barrier and neuromuscular compartment in health and disease

(2020) Vanessa D’Antongiovanni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Glial A2B Adenosine Receptors Modulate Abnormal Tachykininergic Responses and Prevent Enteric Inflammation Associated with High Fat Diet-Induced Obesity

(2020) Vanessa D’Antongiovanni et al.   Cells

Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease

(2020) Laura Benvenuti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy

(2019) Lucia Rota et al.   Translational Neurodegeneration

Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with ulcerative colitis

(2019) Maaike Vancamelbeke et al.   Journal of Crohns & Colitis

Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study

(2019) Koustav Chatterjee et al.   JOURNAL OF NEUROIMMUNOLOGY

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

(2018) Carolina Pellegrini et al.   ACTA NEUROPATHOLOGICA

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Longitudinal Analysis of Fecal Microbiome and Pathologic Processes in a Rotenone Induced Mice Model of Parkinson’s Disease

(2018) Xiaodong Yang et al.   Frontiers in Aging Neuroscience

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

(2018) Paula Perez-Pardo et al.   GUT

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

(2018) Richard Gordon et al.   Science Translational Medicine

A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation

(2018) Carolina Pellegrini et al.   Frontiers in Pharmacology

The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson's Disease

(2018) Alice J. White et al.   Frontiers in Neurology

Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model

(2017) Tingting Chen et al.   Food & Function

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation

(2017) Carolina Pellegrini et al.   Frontiers in Immunology

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

(2016) F Martín-Sánchez et al.   CELL DEATH AND DIFFERENTIATION

Intestinal dysfunction in Parkinson's disease: Lessons learned from translational studies and experimental models

(2016) C. Pellegrini et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

(2016) Marcus M. Unger et al.   PARKINSONISM & RELATED DISORDERS

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

(2016) Natalia Smoktunowicz et al.   Oncotarget

Aberrations in Peripheral Inflammatory Cytokine Levels in Parkinson Disease

(2016) Xiao-Yan Qin et al.   JAMA Neurology

Gastrointestinal dysfunction in Parkinson's disease

(2015) Alfonso Fasano et al.   LANCET NEUROLOGY

Colonic bacterial composition in Parkinson's disease

(2015) Ali Keshavarzian et al.   MOVEMENT DISORDERS

Gastric motor dysfunctions in Parkinson's disease: Current pre-clinical evidence

(2015) Carolina Pellegrini et al.   PARKINSONISM & RELATED DISORDERS

Structural alterations of the intestinal epithelial barrier in Parkinson’s disease

(2015) Thomas Clairembault et al.   Acta Neuropathologica Communications

THP-1 cell line: An in vitro cell model for immune modulation approach

(2014) Wasaporn Chanput et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gut microbiota are related to Parkinson's disease and clinical phenotype

(2014) Filip Scheperjans et al.   MOVEMENT DISORDERS

Altered Protease–Activated Receptor-1 Expression and Signaling in a Malignant Pleural Mesothelioma Cell Line, NCI-H28, with Homozygous Deletion of the β-Catenin Gene

(2014) Alessandra Fazzini et al.   PLoS One

Toll-Like Receptor 2 Regulates Intestinal Inflammation by Controlling Integrity of the Enteric Nervous System

(2013) Paola Brun et al.   GASTROENTEROLOGY

Mechanism of IL-1  Modulation of Intestinal Epithelial Barrier Involves p38 Kinase and Activating Transcription Factor-2 Activation

(2013) R. Al-Sadi et al.   JOURNAL OF IMMUNOLOGY

Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome

(2012) Gloria Lopez-Castejon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Colonic inflammation in Parkinson's disease

(2012) David Devos et al.   NEUROBIOLOGY OF DISEASE

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IL-1β-Induced Increase in Intestinal Epithelial Tight Junction Permeability Is Mediated by MEKK-1 Activation of Canonical NF-κB Pathway

(2010) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PATHOLOGY

Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats

(2010) Rodolphe Soret et al.   GASTROENTEROLOGY

Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers

(2009) Luying Peng et al.   JOURNAL OF NUTRITION

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE