Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy

Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

(2018) Emanuela Colla et al.   NEUROBIOLOGY OF DISEASE

Impaired cholinergic transmission in patients with Parkinson's disease and olfactory dysfunction

(2017) Viviana Versace et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Non-motor features of Parkinson disease

(2017) Anthony H.V. Schapira et al.   NATURE REVIEWS NEUROSCIENCE

Colonic motor dysfunctions in a mouse model of high-fat diet-induced obesity: an involvement of A2B adenosine receptors

(2017) Luca Antonioli et al.   Purinergic Signalling

Constipation: an emerging risk factor for Parkinson's disease?

(2016) P. Stirpe et al.   EUROPEAN JOURNAL OF NEUROLOGY

The Pathophysiology of Chronic Constipation

(2016) Christopher N Andrews et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

Central cholinergic dysfunction could be associated with oropharyngeal dysphagia in early Parkinson’s disease

(2015) Kyung Duck Lee et al.   JOURNAL OF NEURAL TRANSMISSION

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Colonic mucosal  -synuclein lacks specificity as a biomarker for Parkinson disease

(2015) N. P. Visanji et al.   NEUROLOGY

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders

(2014) Ellen Gelpi et al.   MOVEMENT DISORDERS

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats

(2014) Luca Antonioli et al.   PLoS One

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson’s disease: animal models and dopaminergic cell vulnerability

(2014) Javier Blesa et al.   Frontiers in Neuroanatomy

Transfer of human α-synuclein from the olfactory bulb to interconnected brain regions in mice

(2013) Nolwen L. Rey et al.   ACTA NEUROPATHOLOGICA

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Gastrointestinal manifestations in Parkinson’s disease: prevalence and occurrence before motor symptoms

(2012) Maria G. Cersosimo et al.   JOURNAL OF NEUROLOGY

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Is alpha-synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases

(2012) Kathleen M. Shannon et al.   MOVEMENT DISORDERS

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

(2012) Penelope J. Hallett et al.   NEUROBIOLOGY OF DISEASE

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

(2012) Martina Böttner et al.   NEUROBIOLOGY OF DISEASE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Symptoms of rapid eye movement sleep behavior disorder are associated with cholinergic denervation in Parkinson disease

(2011) Vikas Kotagal et al.   ANNALS OF NEUROLOGY

A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease

(2011) Hélène Pouclet et al.   NEUROBIOLOGY OF DISEASE

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

(2010) Thomas G. Beach et al.   ACTA NEUROPATHOLOGICA

MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut

(2010) Gianfranco Natale et al.   BRAIN RESEARCH

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease

(2010) Carine Karachi et al.   JOURNAL OF CLINICAL INVESTIGATION

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

Parkinson's Disease

(2009) Christopher H. Hawkes et al.   Annals of the New York Academy of Sciences

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

(2009) Robert E. Drolet et al.   NEUROBIOLOGY OF DISEASE

Abnormal colonic motility in mice overexpressing human wild-type α-synuclein

(2009) Lixin Wang et al.   NEUROREPORT

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological lesions in colonic biopsies during Parkinson's disease

(2008) T Lebouvier et al.   GUT