Engineering Considerations to Produce Bioactive Compounds from Plant Cell Suspension Culture in Bioreactors

Biotechnological strategies for the sustainable production of diosgenin from Dioscorea spp.

(2021) Romaan Nazir et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Lyophilization stabilizes clinical‐stage core‐crosslinked polymeric micelles to overcome cold chain supply challenges

(2021) Tarun Ojha et al.   Biotechnology Journal

Responses of in vitro cell cultures to elicitation: regulatory role of jasmonic acid and methyl jasmonate: a review

(2021) Neelofer Nabi et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Ginsenosides in Panax genus and their biosynthesis

(2021) Maoqi Hou et al.   Acta Pharmaceutica Sinica B

Cadmium Chloride elicitation of Abutilon indicum cell suspension cultures for enhanced stigmasterol production

(2021) Kiranmayee Rao et al.   PLANT BIOSYSTEMS

A hybrid model based on general regression neural network and fruit fly optimization algorithm for forecasting and optimizing paclitaxel biosynthesis in Corylus avellana cell culture

(2021) Mina Salehi et al.   Plant Methods

Endophytic Bacteria From the Roots of the Medicinal Plant Alkanna tinctoria Tausch (Boraginaceae): Exploration of Plant Growth Promoting Properties and Potential Role in the Production of Plant Secondary Metabolites

(2021) Angélique Rat et al.   Frontiers in Microbiology

Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of the Ferula Genus (Apiaceae)

(2021) Priyankaraj Sonigra et al.   Frontiers in Pharmacology

Suspension Cell Culture of Dioscorea deltoidea—A Renewable Source of Biomass and Furostanol Glycosides for Food and Pharmaceutical Industry

(2021) Maria V. Titova et al.   Agronomy-Basel

Cellular engineering of plant cells for improved therapeutic protein production

(2021) Uddhab Karki et al.   PLANT CELL REPORTS

Impact of light irradiance on the biosynthesis of ABA-elicited phenolic compounds in suspension-cultured Vitis vinifera L. cells

(2021) Seyed Ali Andi et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Growth and Biosynthetic Characteristics of Phlojodicarpus sibiricus Cell Suspension Cultures

(2021) M. T. Khandy et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

Therapeutic and Biomedical Potentialities of Terpenoids – A Review

(2021) Muhammad Jahangeer et al.   JOURNAL OF PURE AND APPLIED MICROBIOLOGY

Bioproduction process of natural products and biopharmaceuticals: Biotechnological aspects

(2021) Ipek Süntar et al.   BIOTECHNOLOGY ADVANCES

Development of Origanum vulgare Cell Suspension Culture to Produce Polyphenols and the Stimulation Effect of Salicylic Acid Elicitation and Phenylalanine Feeding

(2021) Yan-Ping Li et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Transcriptomic analyses of cacao flavonoids produced in photobioreactors

(2021) Adriana M. Gallego et al.   BMC GENOMICS

A mechanistic approach for predicting mass transfer in bioreactors

(2021) John A. Thomas et al.   CHEMICAL ENGINEERING SCIENCE

Enhanced Accumulation of Betulinic Acid in Transgenic Hairy Roots of Senna obtusifolia Growing in the Sprinkle Bioreactor and Evaluation of Their Biological Properties in Various Biological Models

(2021) Tomasz Kowalczyk et al.   CHEMISTRY & BIODIVERSITY

An overview on natural product drug formulations from conventional medicines to nanomedicines: Past, present and future

(2021) Amal Ali Elkordy et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Plants Secondary Metabolites as Blood Glucose-Lowering Molecules

(2021) Mayadah Bashir Shehadeh et al.   MOLECULES

Biotic elicitors: a boon for the in-vitro production of plant secondary metabolites

(2021) Rakesh Bhaskar et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Efficient plant regeneration from embryogenic cell suspension cultures of Euonymus alatus

(2021) Hyun-A Woo et al.   Scientific Reports

Plant callus-derived shikimic acid regenerates human skin through converting human dermal fibroblasts into multipotent skin-derived precursor cells

(2021) Yoo-Wook Kwon et al.   Stem Cell Research & Therapy

Specialized Metabolites and Valuable Molecules in Crop and Medicinal Plants: The Evolution of Their Use and Strategies for Their Production

(2021) Vincenzo D’Amelia et al.   Genes

Biological activity and toxicity of plant nutraceuticals: an overview

(2021) Mercedes Taroncher et al.   Current Opinion in Food Science

Effect of Surface Tension on Hydrodynamics and Mass Transfer Coefficient in Airlift Reactors

(2020) Nikesh Kumar et al.   CHEMICAL ENGINEERING & TECHNOLOGY

Production of antifungal saponins in an airlift bioreactor with a cell line transformed from Solanum chrysotrichum and its activity against strawberry phytopathogens

(2020) Jesús Antonio Salazar-Magallón et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Biotic elicitors enhance diosgenin production in Helicteres isora L. suspension cultures via up-regulation of CAS and HMGR genes

(2020) Samrin Shaikh et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Biotechnological advancements in Catharanthus roseus (L.) G. Don

(2020) Anamika Das et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Sparger design as key parameter to define shear conditions in pneumatic bioreactors

(2020) Mateus N. Esperança et al.   BIOCHEMICAL ENGINEERING JOURNAL

Plant natural products with anti-thyroid cancer activity

(2020) Javad Sharifi-Rad et al.   FITOTERAPIA

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019

(2020) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation

(2020) So Young Gwon et al.   Nutrients

Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections

(2020) Bruno Casciaro et al.   MOLECULES

Human, Animal and Plant Health Benefits of Glucosinolates and Strategies for Enhanced Bioactivity: A Systematic Review

(2020) Sylvia Maina et al.   MOLECULES

Effect of Synthetic Auxin Analogs (2.4-D and α-NAA) on Growth and Biosynthetic Characteristics of Suspension Cell Culture of Tribulus terrestris L.

(2020) S. V. Tomilova et al.   RUSSIAN JOURNAL OF PLANT PHYSIOLOGY

Mathematical Modeling of Growth and Paclitaxel Biosynthesis in Corylus avellana Cell Culture Responding to Fungal Elicitors Using Multilayer Perceptron-Genetic Algorithm

(2020) Mina Salehi et al.   Frontiers in Plant Science

Effects of sorbitol on the production of phenolic compounds and terpenoids in the cell suspension cultures of Ocimum basilicum L.

(2020) Muhammed A. Açıkgöz   BIOLOGIA

Establishment of the hairy root culture of Echium plantagineum L. and its shikonin production

(2020) Jiang-Yan Fu et al.   3 Biotech

Bioactive Compounds in Anti-Diabetic Plants: From Herbal Medicine to Modern Drug Discovery

(2020) Ngan Tran et al.   Biology-Basel

Fluid dynamic conditions and oxygen availability effects on microbial cultures in STBR: An overview

(2020) Felix Garcia-Ochoa et al.   BIOCHEMICAL ENGINEERING JOURNAL

Biotechnological approaches to the production of plant-derived promising anticancer agents: An update and overview

(2020) Li Changxing et al.   BIOMEDICINE & PHARMACOTHERAPY

Ashwagandha: Advances in Plant Biotechnological approaches for propagation and production of bioactive compounds

(2020) Ajay G. Namdeo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Modern Trends in the In Vitro Production and Use of Callus, Suspension Cells and Root Cultures of Medicinal Plants

(2020) Olga Babich et al.   MOLECULES

Production of Verbascoside, Isoverbascoside and Phenolic Acids in Callus, Suspension, and Bioreactor Cultures of Verbena officinalis and Biological Properties of Biomass Extracts

(2020) Paweł Kubica et al.   MOLECULES

Ocimum basilicum suspension culture as resource for bioactive triterpenoids: yield enrichment by elicitation and bioreactor cultivation

(2019) Pallavi Pandey et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Application of genetics and biotechnology for improving medicinal plants

(2019) Mohsen Niazian   PLANTA

Synergistic effect of coronatine and sorbitol on artemisinin production in cell suspension culture of Artemisia annua L. cv. Anamed

(2019) Maryam Salehi et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Cardioprotective Potential of Plant-Derived Molecules: A Scientific and Medicinal Approach

(2019) Syed Muhammad Ali Shah et al.   Dose-Response

Improvement of phytochemical production by plant cells and organ culture and by genetic engineering

(2019) Erik Nielsen et al.   PLANT CELL REPORTS

The Activity of Alkanna Species in vitro Culture and Intact Plant Extracts Against Antibiotic Resistant Bacteria

(2019) N. Sahakyan et al.   CURRENT PHARMACEUTICAL DESIGN

The Structure and Function of Major Plant Metabolite Modifications

(2019) Shouchuang Wang et al.   Molecular Plant

Importance of ethnopharmacological studies in drug discovery: role of medicinal plants

(2019) Ipek Süntar   PHYTOCHEMISTRY REVIEWS

Effect of stirring speed on the production of phenolic secondary metabolites and growth of Buddleja cordata cells cultured in mechanically agitated bioreactor

(2019) Alicia Monserrat Vazquez-Marquez et al.   PLANT CELL TISSUE AND ORGAN CULTURE

A population balance model to modulate shear for the control of aggregation in Taxus suspension cultures

(2019) Sarah A. Wilson et al.   BIOTECHNOLOGY PROGRESS

Optimized Process and Bioreactor Characterization

(2019) Thomas Maischberger   CHEMIE INGENIEUR TECHNIK

Bioactive rinderol and cynoglosol isolated from Cynoglossum columnae Ten. in vitro root culture

(2019) Małgorzata Jeziorek et al.   INDUSTRIAL CROPS AND PRODUCTS

Enhanced production of anthraquinones by gamma-irradiated cell cultures of Rubia cordifolia in a bioreactor

(2019) Mariadoss A et al.   INDUSTRIAL CROPS AND PRODUCTS

Activation of anthraquinone biosynthesis in long-cultured callus culture of Rubia cordifolia transformed with the rolA plant oncogene

(2019) G.N. Veremeichik et al.   JOURNAL OF BIOTECHNOLOGY

Glucosinolate structural diversity, identification, chemical synthesis and metabolism in plants

(2019) Ivica Blažević et al.   PHYTOCHEMISTRY

Optimize, Modulate, and Scale-up Resveratrol and Resveratrol Dimers Bioproduction in Vitis labrusca L. Cell Suspension from Flasks to 20 L Bioreactor

(2019) Carole Lambert et al.   Plants-Basel

Resveratrol production by grapevine cells in fed-batch bioreactor: Experiments and modelling

(2018) Thomas Chastang et al.   BIOCHEMICAL ENGINEERING JOURNAL

Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets

(2018) Marilo Olivares-Vicente et al.   CURRENT DRUG METABOLISM

Screening plant derived dietary phenolic compounds for bioactivity related to cardiovascular disease

(2018) Kevin D. Croft et al.   FITOTERAPIA

In vitro cultivation of Panax ginseng C.A. Meyer

(2018) Muhammad Adil et al.   INDUSTRIAL CROPS AND PRODUCTS

Impacts of hormonal elicitors and photoperiod regimes on elicitation of bioactive secondary volatiles in cell cultures of Ajuga bracteosa

(2018) Huma Ali et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Squalene production in the cell suspension cultures of Indian sandalwood (Santalum album L.) in shake flasks and air lift bioreactor

(2018) Arti Rani et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Suppression of UV-B stress induced flavonoids by biotic stress: Is there reciprocal crosstalk?

(2018) Dirk Schenke et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

In vitro plant tissue culture: means for production of biological active compounds

(2018) Claudia A. Espinosa-Leal et al.   PLANTA

Biotechnological approaches for artemisinin production in Artemisia

(2018) Waqas Khan Kayani et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

An Open-Label, Randomized, Parallel, Phase II Trial to Evaluate the Efficacy and Safety of a Cremophor-Free Polymeric Micelle Formulation of Paclitaxel as First-Line Treatment for Ovarian Cancer: A Korean Gynecologic Oncology Group Study (KGOG-3021)

(2018) Shin-Wha Lee et al.   Cancer Research and Treatment

Bioreactor Scale-Down Studies of Suspended Plant Cell Cultures

(2018) Caleb K.-L. Cheung et al.   AICHE JOURNAL

Plant cell culture technology in the cosmetics and food industries: current state and future trends

(2018) Regine Eibl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Effect of oxygen transfer on yeast growth — Growth kinetic and reactor model to estimate scale-up effects in bioreactors

(2018) Petri Tervasmäki et al.   FOOD AND BIOPRODUCTS PROCESSING

Role of secondary metabolites in plant defense against pathogens

(2018) Madiha Zaynab et al.   MICROBIAL PATHOGENESIS

Bioreactor-based advances in plant tissue and cell culture: challenges and prospects

(2018) Alireza Valdiani et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Ginsenoside accumulation profiles in long- and short-term cell suspension and adventitious root cultures in Panax ginseng

(2018) Kim-Cuong Le et al.   Horticulture Environment and Biotechnology

Effects of chitosan and salicylic acid on the production of pharmacologically attractive secondary metabolites in callus cultures of Fagonia indica

(2018) Taimoor Khan et al.   INDUSTRIAL CROPS AND PRODUCTS

Traditional Medicine for Wound Management

(2017) Ipek Suntar et al.   Evidence-based Complementary and Alternative Medicine

Optical Approach for Measuring Oxygen Mass Transfer in Stirred Tank Bioreactors

(2017) Jorge Isaac Martínez-Corona et al.   International Journal of Chemical Reactor Engineering

Multi-target Activities of Selected Alkaloids and Terpenoids

(2017) Aida Rodriguez-Garcia et al.   MINI-REVIEWS IN ORGANIC CHEMISTRY

Elicitation: a stimulation of stress in in vitro plant cell/tissue cultures for enhancement of secondary metabolite production

(2017) M. Narayani et al.   PHYTOCHEMISTRY REVIEWS

Secondary metabolism of pharmaceuticals in the plant in vitro cultures: strategies, approaches, and limitations to achieving higher yield

(2017) Tasiu Isah et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Advances in airlift reactors: modified design and optimization of operation conditions

(2017) Tao Zhang et al.   REVIEWS IN CHEMICAL ENGINEERING

Anthocyanidins and anthocyanins: colored pigments as food, pharmaceutical ingredients, and the potential health benefits

(2017) Hock Eng Khoo et al.   Food & Nutrition Research

Kinetic, oxygen mass transfer and hydrodynamic studies in a three-phase stirred tank bioreactor for the bioconversion of (+)-valencene on Yarrowia lipolytica 2.2ab

(2016) D.M. Palmerín-Carreño et al.   BIOCHEMICAL ENGINEERING JOURNAL

Rheology and mixing analysis of plant cell cultures (Azadirachta indica, Borojoa patinoi and Thevetia peruviana) in shake flasks

(2016) Astrid Catalina Alvarez-Yela et al.   BIOCHEMICAL ENGINEERING JOURNAL

Structured model and parameter estimation in plant cell cultures of Thevetia peruviana

(2016) Adriana Villegas et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Plant cell culture strategies for the production of natural products

(2016) Marisol Ochoa-Villarreal et al.   BMB Reports

Methyl jasmonate enhanced production of rosmarinic acid in cell cultures ofSatureja khuzistanicain a bioreactor

(2016) Abbas Khojasteh et al.   ENGINEERING IN LIFE SCIENCES

Phenolic profile, antioxidant activity and enzyme inhibitory activities of extracts from aromatic plants used in Mediterranean diet

(2016) Sandra Gonçalves et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Optimization of methyl jasmonate and β-cyclodextrin for enhanced production of taraxerol and taraxasterol in (Taraxacum officinale Weber) cultures

(2016) Kiran Sharma et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

Characterization of the Promoter Region of Biosynthetic Enzyme Genes Involved in Berberine Biosynthesis in Coptis japonica

(2016) Yasuyuki Yamada et al.   Frontiers in Plant Science

Model based fed batch cultivation and elicitation for the overproduction of ajmalicine from hairy roots of Catharanthus roseus

(2015) Dhara Thakore et al.   BIOCHEMICAL ENGINEERING JOURNAL

Biotechnological enhancement of capsaicin biosynthesis in cell suspension cultures of Naga King Chili (Capsicum chinense Jacq.)

(2015) Mechuselie Kehie et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Aggregate cell suspension cultures of Psoralea corylifolia improved phytoestrogens production

(2015) Ramesh Satdive et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Establishment and characterization of a Satureja khuzistanica Jamzad (Lamiaceae) cell suspension culture: a new in vitro source of rosmarinic acid

(2015) Amir Sahraroo et al.   CYTOTECHNOLOGY

Bioproduction of phenylethanoid glycosides by plant cell culture of Scrophularia striata Boiss.: from shake-flasks to bioreactor

(2015) Sedigheh Ahmadi-Sakha et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Modeling of plant in vitro cultures: Overview and estimation of biotechnological processes

(2014) Rüdiger W. Maschke et al.   BIOTECHNOLOGY AND BIOENGINEERING

Bioreactors for plant cells: hardware configuration and internal environment optimization as tools for wider commercialization

(2014) Milen I. Georgiev et al.   BIOTECHNOLOGY LETTERS

Medicinal plant cell suspension cultures: pharmaceutical applications and high-yielding strategies for the desired secondary metabolites

(2014) Wei Yue et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Multi-scale engineering of plant cell cultures for promotion of specialized metabolism

(2014) Sarah A Wilson et al.   CURRENT OPINION IN BIOTECHNOLOGY

Light-induced fluctuations in biomass accumulation, secondary metabolites production and antioxidant activity in cell suspension cultures of Artemisia absinthium L.

(2014) Mohammad Ali et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Hosting the plant cells in vitro: recent trends in bioreactors

(2013) Milen I. Georgiev et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Anthraquinones production in Rubia tinctorum cell suspension cultures: Down scale of shear effects

(2013) Víctor D. Busto et al.   BIOCHEMICAL ENGINEERING JOURNAL

STUDY OF THE AGGLOMERATION MECHANISM OF A NATURAL ORGANIC SOLID IN A BENCH-SCALE WET FLUIDIZED BED USING STATISTICAL ANALYSIS AND DISCRETIZED POPULATION BALANCE

(2013) D. Ríos-Morales et al.   CHEMICAL ENGINEERING COMMUNICATIONS

Kinetic mathematical model for ketone bioconversion using Escherichia coli TOP10 pQR239

(2013) R. Melgarejo-Torres et al.   CHEMICAL ENGINEERING JOURNAL

Production of biomass and bioactive compounds by adventitious root suspension cultures of Morinda citrifolia (L.) in a liquid-phase airlift balloon-type bioreactor

(2013) Md. Abdullahil Baque et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Enhanced production of napthoquinone metabolite (shikonin) from cell suspension culture of Arnebia sp. and its up-scaling through bioreactor

(2013) Komal Gupta et al.   3 Biotech

Isolation and characterization of diosgenin from in vitro cultured tissues of Helicteres isora L

(2013) Harshal A. Deshpande et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Bioprocessing of differentiated plant in vitro systems

(2012) Juliane Steingroewer et al.   ENGINEERING IN LIFE SCIENCES

Analysis of aggregate size as a process variable affecting paclitaxel accumulation in Taxus suspension cultures

(2011) Martin E. Kolewe et al.   BIOTECHNOLOGY PROGRESS

Physico-chemical factors influencing the shikonin derivatives production in cell suspension cultures ofArnebia euchroma(Royle) Johnston, a medicinally important plant species

(2010) Sonia Malik et al.   CELL BIOLOGY INTERNATIONAL

Phenylpropanoid production in callus and cell suspension cultures of Buddleja cordata Kunth

(2010) M. E. Estrada-Zúñiga et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Production of the anticancer drug taxol in Taxus baccata suspension cultures: A review

(2010) Sonia Malik et al.   PROCESS BIOCHEMISTRY

Bioprocessing of plant cell cultures for mass production of targeted compounds

(2009) Milen I. Georgiev et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bioreactor engineering for recombinant protein production in plant cell suspension cultures

(2009) Ting-Kuo Huang et al.   BIOCHEMICAL ENGINEERING JOURNAL

pH measurement and a rational and practical pH control strategy for high throughput cell culture system

(2009) Haiying Zhou et al.   BIOTECHNOLOGY PROGRESS

Robust optimization in simulation: Taguchi and Response Surface Methodology

(2009) Gabriella Dellino et al.   INTERNATIONAL JOURNAL OF PRODUCTION ECONOMICS

Metabolism, cell growth and the bacterial cell cycle

(2009) Jue D. Wang et al.   NATURE REVIEWS MICROBIOLOGY

Influence of minerals and elicitation on Datura stramonium L. tropane alkaloid production: Modelization of the in vitro biochemical response

(2009) R. Amdoun et al.   PLANT SCIENCE

Bioreactor scale-up and oxygen transfer rate in microbial processes: An overview

(2008) Felix Garcia-Ochoa et al.   BIOTECHNOLOGY ADVANCES

Response surface design evaluation and comparison

(2008) Christine M. Anderson-Cook et al.   JOURNAL OF STATISTICAL PLANNING AND INFERENCE

Pharmaceutically Active Natural Product Synthesis and Supply via Plant Cell Culture Technology

(2008) Martin E. Kolewe et al.   MOLECULAR PHARMACEUTICS

Effect of Shear Stress on Anthraquinones Production by Rubia tinctorum Suspension Cultures

(2007) V.D. Busto et al.   BIOTECHNOLOGY PROGRESS