Evidence of Energy Metabolism Alterations in Cultured Neonatal Astrocytes Derived from the Ts65Dn Mouse Model of Down Syndrome

Down syndrome is an oxidative phosphorylation disorder

(2021) M.Pilar Bayona-Bafaluy et al.   Redox Biology

Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism

(2021) Colin C. Anderson et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in a 6-month old Mouse Model of Down Syndrome and Alzheimer’s Disease

(2021) Melissa J. Alldred et al.   Frontiers in Aging Neuroscience

Rethinking Intellectual Disability from Neuro- to Astro-Pathology

(2020) Álvaro Fernández-Blanco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Shape of Mitochondrial Dysfunction in Down Syndrome

(2019) E. Zamponi et al.   Developmental Neurobiology

Adult Neurogenesis, Glia, and the Extracellular Matrix

(2019) Elise C. Cope et al.   Cell Stem Cell

Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity

(2019) Caroline Fecher et al.   NATURE NEUROSCIENCE

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

(2019) Theodora Panagaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do Astrocytes Play a Role in Intellectual Disabilities?

(2019) Noémie Cresto et al.   TRENDS IN NEUROSCIENCES

Down Syndrome Critical Region 1 Gene,Rcan1, Helps Maintain a More Fused Mitochondrial NetworkNovelty and Significance

(2018) Valentina Parra et al.   CIRCULATION RESEARCH

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

(2018) Antonella Izzo et al.   MOLECULAR MEDICINE

Astrocytic metabolic switch is a novel etiology for Cocaine and HIV-1 Tat-mediated neurotoxicity

(2018) Kalimuthusamy Natarajaseenivasan et al.   Cell Death & Disease

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

Metformin restores the mitochondrial network and reverses mitochondrial dysfunction in Down syndrome cells

(2017) Antonella Izzo et al.   HUMAN MOLECULAR GENETICS

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

(2016) Daniela Valenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

(2016) Fei Yin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Astrocytic β2-adrenergic receptors mediate hippocampal long-term memory consolidation

(2016) Virginia Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypocellularity in the Murine Model for Down Syndrome Ts65Dn Is Not Affected by Adult Neurogenesis

(2016) Rosa López-Hidalgo et al.   Frontiers in Neuroscience

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

(2015) Ciaran Murphy-Royal et al.   NATURE NEUROSCIENCE

Assessment of Cognitive Scales to Examine Memory, Executive Function and Language in Individuals with Down Syndrome: Implications of a 6-month Observational Study

(2015) Xavier Liogier d'Ardhuy et al.   Frontiers in Behavioral Neuroscience

Astrocytic metabolic and inflammatory changes as a function of age

(2014) Tianyi Jiang et al.   AGING CELL

NRIP1/RIP140 siRNA-mediated attenuation counteracts mitochondrial dysfunction in Down syndrome

(2014) Antonella Izzo et al.   HUMAN MOLECULAR GENETICS

Neuronal Activity and Glutamate Uptake Decrease Mitochondrial Mobility in Astrocytes and Position Mitochondria Near Glutamate Transporters

(2014) J. G. Jackson et al.   JOURNAL OF NEUROSCIENCE

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

(2013) Pablo Helguera et al.   Cell Metabolism

Prospects for Improving Brain Function in Individuals with Down Syndrome

(2013) Alberto C. S. Costa et al.   CNS DRUGS

Emerging roles of astrocytes in neural circuit development

(2013) Laura E. Clarke et al.   NATURE REVIEWS NEUROSCIENCE

Lymphocyte respiration in children with Trisomy 21

(2012) Elhadi H Aburawi et al.   BMC Pediatrics

Chronic pro-oxidative state and mitochondrial dysfunctions are more pronounced in fibroblasts from Down syndrome foeti with congenital heart defects

(2012) C. Piccoli et al.   HUMAN MOLECULAR GENETICS

Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway

(2011) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

Impairment of F1F0-ATPase, adenine nucleotide translocator and adenylate kinase causes mitochondrial energy deficit in human skin fibroblasts with chromosome 21 trisomy

(2010) Daniela Valenti et al.   BIOCHEMICAL JOURNAL

Updated national birth prevalence estimates for selected birth defects in the United States, 2004-2006

(2010) Samantha E. Parker et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis

(2009) Ethan G. Hughes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mitochondrial dysfunction in mouse trisomy 16 brain

(2007) L.L. Bambrick et al.   BRAIN RESEARCH