Oxidative Phosphorylation Is Dysregulated Within the Basocortical Circuit in a 6-month old Mouse Model of Down Syndrome and Alzheimer’s Disease

Down syndrome is an oxidative phosphorylation disorder

(2021) M.Pilar Bayona-Bafaluy et al.   Redox Biology

Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome

(2021) Chiara Lanzillotta et al.   FREE RADICAL BIOLOGY AND MEDICINE

Profiling Basal Forebrain Cholinergic Neurons Reveals a Molecular Basis for Vulnerability Within the Ts65Dn Model of Down Syndrome and Alzheimer’s Disease

(2021) Melissa J. Alldred et al.   MOLECULAR NEUROBIOLOGY

Basal forebrain volume reliably predicts the cortical spread of Alzheimer’s degeneration

(2020) Sara Fernández-Cabello et al.   BRAIN

Targeting Mitochondrial Network Architecture in Down Syndrome and Aging

(2020) Nunzia Mollo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuropathological features associated with basal forebrain atrophy in Alzheimer’s disease

(2020) Stefan J. Teipel et al.   NEUROLOGY

Combined Microscopic and Metabolomic Approach to Characterize the Skeletal Muscle Fiber of the Ts65Dn Mouse, A Model of Down Syndrome

(2020) Barbara Cisterna et al.   MICROSCOPY AND MICROANALYSIS

Long-term effects of maternal choline supplementation on CA1 pyramidal neuron gene expression in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease

(2019) Melissa J. Alldred et al.   FASEB JOURNAL

RNA sequencing: the teenage years

(2019) Rory Stark et al.   NATURE REVIEWS GENETICS

mTOR hyperactivation in Down Syndrome underlies deficits in autophagy induction, autophagosome formation, and mitophagy

(2019) Matteo Bordi et al.   Cell Death & Disease

Pioglitazone Improves Mitochondrial Organization and Bioenergetics in Down Syndrome Cells

(2019) Nunzia Mollo et al.   Frontiers in Genetics

Nerve Growth Factor Pathobiology During the Progression of Alzheimer’s Disease

(2019) Elliott J. Mufson et al.   Frontiers in Neuroscience

National population‐based estimates for major birth defects, 2010–2014

(2019) Cara T. Mai et al.   Birth Defects Research

Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease

(2019) Enrica Cavedo et al.   NEUROLOGY

Mitochondria as pharmacological targets in Down syndrome

(2018) Daniela Valenti et al.   FREE RADICAL BIOLOGY AND MEDICINE

CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation

(2018) Melissa J. Alldred et al.   HIPPOCAMPUS

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

(2018) Antonella Izzo et al.   MOLECULAR MEDICINE

The Simple Western™: a gel-free, blot-free, hands-free Western blotting reinvention

(2018) Uyen Nguyen et al.   NATURE METHODS

Age exacerbates abnormal protein expression in a mouse model of Down syndrome

(2017) Md. Mahiuddin Ahmed et al.   NEUROBIOLOGY OF AGING

Cognitive Profiles on the Severe Impairment Battery Are Similar in Alzheimer Disease and Down Syndrome With Dementia

(2016) Malcolm B. Dick et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Why has therapy development for dementia failed in the last two decades?

(2016) Serge Gauthier et al.   Alzheimers & Dementia

The pattern of amyloid accumulation in the brains of adults with Down syndrome

(2016) Tiina Annus et al.   Alzheimers & Dementia

Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy

(2016) Matteo Bordi et al.   Autophagy

Molecular and cellular pathophysiology of preclinical Alzheimer’s disease

(2016) Elliott J. Mufson et al.   BEHAVIOURAL BRAIN RESEARCH

The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model

(2016) Daniela Valenti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria

(2016) Ryan J. Mailloux et al.   FEBS LETTERS

Plant polyphenols as natural drugs for the management of Down syndrome and related disorders

(2016) Rosa Anna Vacca et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Down syndrome and Alzheimer's disease: Common pathways, common goals

(2015) Dean Hartley et al.   Alzheimers & Dementia

Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome

(2015) Brian E. Powers et al.   Brain Structure & Function

Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease

(2015) Barbara J. Strupp et al.   Current Alzheimer Research

Nerve growth factor metabolic dysfunction in Down’s syndrome brains

(2014) M. Florencia Iulita et al.   BRAIN

Expression profile analysis of hippocampal CA1 pyramidal neurons in aged Ts65Dn mice, a model of Down syndrome (DS) and Alzheimer’s disease (AD)

(2014) Melissa J. Alldred et al.   Brain Structure & Function

Maternal choline supplementation programs greater activity of the phosphatidylethanolamine N-methyltransferase (PEMT) pathway in adult Ts65Dn trisomic mice

(2014) Jian Yan et al.   FASEB JOURNAL

Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice

(2014) Melissa J. Alldred et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: An overview of Down syndrome, autism, Fragile X and Rett syndrome

(2014) Daniela Valenti et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Sex Differences in the Cholinergic Basal Forebrain in the Ts65Dn Mouse Model of Down Syndrome and Alzheimer's Disease

(2013) Christy M. Kelley et al.   BRAIN PATHOLOGY

Adaptive Downregulation of Mitochondrial Function in Down Syndrome

(2013) Pablo Helguera et al.   Cell Metabolism

Maternal choline supplementation differentially alters the basal forebrain cholinergic system of young-adult Ts65Dn and disomic mice

(2013) Christy M. Kelley et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Current Estimate of Down Syndrome Population Prevalence in the United States

(2013) Angela P. Presson et al.   JOURNAL OF PEDIATRICS

Cognitive and pharmacological insights from the Ts65Dn mouse model of Down syndrome

(2012) Aarti Ruparelia et al.   CURRENT OPINION IN NEUROBIOLOGY

Oxidative Phosphorylation, Not Glycolysis, Powers Presynaptic and Postsynaptic Mechanisms Underlying Brain Information Processing

(2012) C. N. Hall et al.   JOURNAL OF NEUROSCIENCE

Treatment of Alzheimer disease in Down syndrome

(2012) Alberto C. Costa   Nature Reviews Neurology

Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer's disease

(2012) Michel Grothe et al.   NEUROBIOLOGY OF AGING

Mouse Models of Down Syndrome as a Tool to Unravel the Causes of Mental Disabilities

(2012) Noemí Rueda et al.   NEURAL PLASTICITY

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

Microarray analysis of CA1 pyramidal neurons in a mouse model of tauopathy reveals progressive synaptic dysfunction

(2011) Melissa J. Alldred et al.   NEUROBIOLOGY OF DISEASE

Microarray Analysis of Hippocampal CA1 Neurons Implicates Early Endosomal Dysfunction During Alzheimer's Disease Progression

(2010) Stephen D. Ginsberg et al.   BIOLOGICAL PSYCHIATRY

Cognitive deficits and associated neurological complications in individuals with Down's syndrome

(2010) Ira T Lott et al.   LANCET NEUROLOGY

Alzheimer's-related endosome dysfunction in Down syndrome is A -independent but requires APP and is reversed by BACE-1 inhibition

(2009) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholinergic system during the progression of Alzheimer’s disease: therapeutic implications

(2008) Elliott J Mufson et al.   Expert Review of Neurotherapeutics

Terminal Continuation (TC) RNA Amplification Enables Expression Profiling Using Minute RNA Input Obtained from Mouse Brain

(2008) Melissa Alldred et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of down syndrome

(2008) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Alzheimer's disease and Down's syndrome: an in vivo MRI study

(2008) F. Beacher et al.   PSYCHOLOGICAL MEDICINE

Mitochondrial dysfunction in mouse trisomy 16 brain

(2007) L.L. Bambrick et al.   BRAIN RESEARCH