Prospects for Improving Brain Function in Individuals with Down Syndrome

GluN2B Antagonism Affects Interneurons and Leads to Immediate and Persistent Changes in Synaptic Plasticity, Oscillations and Behavior

(2013) Jesse E Hanson et al.   NEUROPSYCHOPHARMACOLOGY

Cytogenetic and epidemiological findings in Down syndrome: England and Wales 1989-2009

(2012) Joan K. Morris et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Early Pharmacotherapy with Fluoxetine Rescues Dendritic Pathology in the Ts65Dn Mouse Model of Down Syndrome

(2012) Sandra Guidi et al.   BRAIN PATHOLOGY

N-Methyl-d-aspartate (NMDA) Receptor Composition Modulates Dendritic Spine Morphology in Striatal Medium Spiny Neurons

(2012) Csaba Vastagh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

(2012) Bozena Mazur-Kolecka et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial

(2012) Marisa Hanney et al.   LANCET

Lack of behavioral and cognitive effects of chronic ethosuximide and gabapentin treatment in the Ts65Dn mouse model of Down syndrome

(2012) V. Vidal et al.   NEUROSCIENCE

Adult-Onset Fluoxetine Treatment Does Not Improve Behavioral Impairments and May Have Adverse Effects on the Ts65Dn Mouse Model of Down Syndrome

(2012) Markus Heinen et al.   NEURAL PLASTICITY

Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial

(2012) R Boada et al.   Translational Psychiatry

Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

(2011) Ira T. Lott et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

On the Promise of Pharmacotherapies Targeted at Cognitive and Neurodegenerative Components of Down Syndrome

(2011) Alberto C.S. Costa   DEVELOPMENTAL NEUROSCIENCE

Abnormal MicroRNA Expression in Ts65Dn Hippocampus and Whole Blood: Contributions to Down Syndrome Phenotypes

(2011) Jennifer Keck-Wherley et al.   DEVELOPMENTAL NEUROSCIENCE

Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome

(2011) Tyler K. Best et al.   EXPERIMENTAL NEUROLOGY

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

(2011) Mototada Shichiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

(2011) Stefania Trazzi et al.   HUMAN MOLECULAR GENETICS

Donepezil Significantly Improves Abilities in Daily Lives of Female down Syndrome Patients with Severe Cognitive Impairment: A 24-Week Randomized, Double-Blind, Placebo-Controlled Trial

(2011) Tatsuro Kondoh et al.   INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE

Rescue of Synaptic Failure and Alleviation of Learning and Memory Impairments in a Trisomic Mouse Model of Down Syndrome

(2011) Julie Blanchard et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice

(2011) J Braudeau et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Exaggerated NMDA mediated LTD in a mouse model of Down syndrome and pharmacological rescuing by memantine

(2011) J. J. Scott-McKean et al.   LEARNING & MEMORY

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down Syndrome: Activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer

(2011) Mehrdad Faizi et al.   NEUROBIOLOGY OF DISEASE

Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome

(2011) Alexander M. Kleschevnikov et al.   NEUROBIOLOGY OF DISEASE

Prevention of Learning Deficit in a Down Syndrome Model

(2011) Maddalena Incerti et al.   OBSTETRICS AND GYNECOLOGY

Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome

(2011) Tatjana Begenisic et al.   Frontiers in Cellular Neuroscience

Defining optimal treatment with cholinesterase inhibitors in Alzheimer's disease

(2010) Gary Small et al.   Alzheimers & Dementia

Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17

(2010) Priya S. Kishnani et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome.

(2010) Jisook Moon et al.   BEHAVIORAL NEUROSCIENCE

Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

(2010) Jason Lockrow et al.   BEHAVIOURAL BRAIN RESEARCH

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

Early Pharmacotherapy Restores Neurogenesis and Cognitive Performance in the Ts65Dn Mouse Model for Down Syndrome

(2010) P. Bianchi et al.   JOURNAL OF NEUROSCIENCE

Stimulated neuronal expression of brain-derived neurotrophic factor by Neurotropin

(2010) Yu Fukuda et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Targeted treatments for cognitive and neurodevelopmental disorders in tuberous sclerosis complex

(2010) Petrus J. Vries   Neurotherapeutics

Prevention of Developmental Delays in a Down Syndrome Mouse Model

(2010) Laura Toso et al.   OBSTETRICS AND GYNECOLOGY

Lowering β-Amyloid Levels Rescues Learning and Memory in a Down Syndrome Mouse Model

(2010) William J. Netzer et al.   PLoS One

Can Animal Models of Disease Reliably Inform Human Studies?

(2010) H. Bart van der Worp et al.   PLOS MEDICINE

The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome

(2009) Priya S. Kishnani et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Structural Features of Ischemic Damage in the Hippocampus

(2009) Alexander G. Nikonenko et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Behavioral validation of the Ts65Dn mouse model for Down syndrome of a genetic background free of the retinal degeneration mutation Pde6brd1

(2009) Alberto C.S. Costa et al.   BEHAVIOURAL BRAIN RESEARCH

Function and regulation of Dyrk1A: towards understanding Down syndrome

(2009) Joongkyu Park et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The California Verbal Learning Test and other standard clinical neuropsychological tests to predict conversion from mild memory impairment to dementia

(2009) Françoise Lekeu et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Age-dependent dysregulation of brain amyloid precursor protein in the Ts65Dn Down syndrome mouse model

(2009) Jennifer H. K. Choi et al.   JOURNAL OF NEUROCHEMISTRY

The "Down Syndrome Critical Region" Is Sufficient in the Mouse Model to Confer Behavioral, Neurophysiological, and Synaptic Phenotypes Characteristic of Down Syndrome

(2009) N. P. Belichenko et al.   JOURNAL OF NEUROSCIENCE

Green Tea Polyphenols Rescue of Brain Defects Induced by Overexpression of DYRK1A

(2009) Fayçal Guedj et al.   PLoS One

DYRK1A, a Novel Determinant of the Methionine-Homocysteine Cycle in Different Mouse Models Overexpressing this Down-Syndrome-Associated Kinase

(2009) Christophe Noll et al.   PLoS One

Restoration of Norepinephrine-Modulated Contextual Memory in a Mouse Model of Down Syndrome

(2009) A. Salehi et al.   Science Translational Medicine

RETRACTED: Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts

(2008) Donald E. Kuhn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trisomy 21 and Down syndrome: a short review

(2008) CA. Sommer et al.   BRAZILIAN JOURNAL OF BIOLOGY

Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model

(2008) Jason Lockrow et al.   EXPERIMENTAL NEUROLOGY

Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

(2008) A. Siddiqui et al.   GENES BRAIN AND BEHAVIOR

Effect of Simvastatin on Cognitive Functioning in Children With Neurofibromatosis Type 1

(2008) Lianne C. Krab   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Regulation of dendritic spine morphology by an NMDA receptor-associated Rho GTPase-activating protein, p250GAP

(2008) Takanobu Nakazawa et al.   JOURNAL OF NEUROCHEMISTRY

Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?

(2008) A. J. Eisch et al.   JOURNAL OF NEUROSCIENCE

Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome

(2008) X. Altafaj et al.   NEUROBIOLOGY OF DISEASE

Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity

(2008) Koji Yashiro et al.   NEUROPHARMACOLOGY

Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

(2008) N. Rueda et al.   NEUROSCIENCE LETTERS

Oxidative stress and cognitive ability in adults with Down syndrome

(2008) Andre Strydom et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Supplementation with antioxidants and folinic acid for children with Down’s syndrome: randomised controlled trial

(2008) Jill M Ellis et al.   BMJ-British Medical Journal

Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome

(2007) Qing Chang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY