Crumbling the Castle: Targeting DNABII Proteins for Collapsing Bacterial Biofilms as a Therapeutic Approach to Treat Disease and Combat Antimicrobial Resistance

A Humanized Monoclonal Antibody Potentiates Killing by Antibiotics of Diverse Biofilm-Forming Respiratory Tract Pathogens

(2022) Nikola Kurbatfinski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi

(2021) Aishwarya Devaraj et al.   PLoS Pathogens

Humanized Anti‐DNABII Fab Fragments Plus Ofloxacin Eradicated Biofilms in Experimental Otitis Media

(2021) Laura A. Novotny et al.   LARYNGOSCOPE

The CARB-X Portfolio of Nontraditional Antibacterial Products

(2021) Erin M. Duffy et al.   ACS Infectious Diseases

Z-form extracellular DNA is a structural component of the bacterial biofilm matrix

(2021) John R. Buzzo et al.   CELL

How to manage treatment failure in prosthetic joint infection

(2020) T.N. Peel et al.   CLINICAL MICROBIOLOGY AND INFECTION

Targeting a bacterial DNABII protein with a chimeric peptide immunogen or humanised monoclonal antibody to prevent or treat recalcitrant biofilm-mediated infections

(2020) Laura A. Novotny et al.   EBioMedicine

National Estimates of Healthcare Costs Associated With Multidrug-Resistant Bacterial Infections Among Hospitalized Patients in the United States

(2020) Richard E Nelson et al.   CLINICAL INFECTIOUS DISEASES

Antibiotics versus biofilm: an emerging battleground in microbial communities

(2019) Divakar Sharma et al.   Antimicrobial Resistance and Infection Control

Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms

(2019) Jing Yan et al.   Cell Host & Microbe

Antibodies against the DNABII protein integration host factor (IHF) inhibit sinus implant biofilms

(2019) Lauren Martyn et al.   LARYNGOSCOPE

‘It takes a village’: mechanisms underlying antimicrobial recalcitrance of polymicrobial biofilms

(2019) Giulia Orazi et al.   JOURNAL OF BACTERIOLOGY

An early, biofilm-focused wound management approach

(2019) Camila Fronzo   Journal of Wound Care

The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates

(2019) Aishwarya Devaraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redirecting the immune response towards immunoprotective domains of a DNABII protein resolves experimental otitis media

(2019) L. A. Novotny et al.   npj Vaccines

Simulation-Based Exploration of Quorum Sensing Triggered Resistance of Biofilms to Antibiotics

(2018) Maryam Ghasemi et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Targeting the HUβ Protein Prevents Porphyromonas gingivalis from Entering into Preexisting Biofilms

(2018) Christopher J. Rocco et al.   JOURNAL OF BACTERIOLOGY

Skin Microbiota in Obese Women at Risk for Surgical Site Infection After Cesarean Delivery

(2018) Kara M. Rood et al.   Scientific Reports

HU of Streptococcus pneumoniae Is Essential for the Preservation of DNA Supercoiling

(2018) María-José Ferrándiz et al.   Frontiers in Microbiology

What are the advantages of living in a community? A microbial biofilm perspective!

(2018) André Luis Souza dos Santos et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Targeting microbial biofilms: current and prospective therapeutic strategies

(2017) Hyun Koo et al.   NATURE REVIEWS MICROBIOLOGY

Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action

(2017) Ranita Roy et al.   Virulence

Integration host factor is important for biofilm formation by Salmonella enterica Enteritidis

(2017) Bruna Leite et al.   Pathogens and Disease

The DNABII family of proteins is comprised of the only nucleoid associated proteins required for nontypeable Haemophilus influenzae biofilm structure

(2017) Aishwarya Devaraj et al.   MicrobiologyOpen

What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention

(2016) John S. Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of biofilms in post-tympanostomy tube otorrhea

(2016) Winslo K. Idicula et al.   LARYNGOSCOPE

A bacterial-biofilm-induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid-associated protein

(2016) M.O. Freire et al.   Molecular Oral Microbiology

Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics

(2016) C.J. Rocco et al.   Molecular Oral Microbiology

Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?

(2016) Marlieke E. A. de Kraker et al.   PLOS MEDICINE

Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo

(2016) Laura A. Novotny et al.   EBioMedicine

Biofilm formation mechanisms and targets for developing antibiofilm agents

(2015) Nira Rabin et al.   Future Medicinal Chemistry

DNABII proteins play a central role in UPEC biofilm structure

(2015) Aishwarya Devaraj et al.   MOLECULAR MICROBIOLOGY

Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics

(2014) D. Lebeaux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms

(2014) M. Elizabeth Brockson et al.   MOLECULAR MICROBIOLOGY

Biofilm infections, their resilience to therapy and innovative treatment strategies

(2013) U. Römling et al.   JOURNAL OF INTERNAL MEDICINE

Antibodies directed against integration host factor mediate biofilm clearance from nasopore

(2013) Kathleyn A. Brandstetter et al.   LARYNGOSCOPE

Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein

(2013) Laura A. Novotny et al.   PLoS One

Self-organization of bacterial biofilms is facilitated by extracellular DNA

(2013) E. S. Gloag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular DNA-induced antimicrobial peptide resistance mechanisms in Pseudomonas aeruginosa

(2013) Shawn Lewenza   Frontiers in Microbiology

Biofilm-specific antibiotic resistance

(2012) Thien-Fah Mah   Future Microbiology

Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis

(2012) Jodi E. Gustave et al.   Journal of Cystic Fibrosis

Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins

(2011) S D Goodman et al.   Mucosal Immunology

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Extracellular DNA Chelates Cations and Induces Antibiotic Resistance in Pseudomonas aeruginosa Biofilms

(2008) Heidi Mulcahy et al.   PLoS Pathogens