The CARB-X Portfolio of Nontraditional Antibacterial Products

Pseudomonas aeruginosa elastase (LasB) as a therapeutic target

(2021) Martin J Everett et al.   DRUG DISCOVERY TODAY

Adjunctive therapy for multidrug-resistant bacterial infections: Type III secretion system and efflux inhibitors

(2021) Donald T. Moir et al.   DRUG DISCOVERY TODAY

Type 3 secretion system of Pseudomonas aeruginosa

(2021) Gertrudis Horna et al.   MICROBIOLOGICAL RESEARCH

Antimicrobial activity of POL7306 tested against clinical isolates of Gram-negative bacteria collected worldwide

(2020) Helio S Sader et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Chemotherapy-induced ileal crypt apoptosis and the ileal microbiome shape immunosurveillance and prognosis of proximal colon cancer

(2020) Maria Paula Roberti et al.   NATURE MEDICINE

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases

(2020) Thomas F. Durand-Réville et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cellular Nanosponges Inhibit SARS-CoV-2 Infectivity

(2020) Qiangzhe Zhang et al.   NANO LETTERS

Narrow-Spectrum Antibacterial Agents—Benefits and Challenges

(2020) Richard A. Alm et al.   Antibiotics-Basel

FimH and Anti-Adhesive Therapeutics: A Disarming Strategy Against Uropathogens

(2020) Meysam Sarshar et al.   Antibiotics-Basel

Lessons Learned From the First 10 Consecutive Cases of Intravenous Bacteriophage Therapy to Treat Multidrug-Resistant Bacterial Infections at a Single Center in the United States

(2020) Saima Aslam et al.   Open Forum Infectious Diseases

Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus

(2019) Rebekah M. Dedrick et al.   NATURE MEDICINE

Non-traditional Antibacterial Therapeutic Options and Challenges

(2019) Ursula Theuretzbacher et al.   Cell Host & Microbe

Designing development programs for non-traditional antibacterial agents

(2019) John H. Rex et al.   Nature Communications

Staphylococcus aureus α-toxin: small pore, large consequences

(2019) Gisela von Hoven et al.   BIOLOGICAL CHEMISTRY

Endolysins as emerging alternative therapeutic agent to counter drug resistant infections.

(2019) Vijay Singh Gondil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Broad and Efficient Control of Klebsiella Pathogens by Peptidoglycan-Degrading and Pore-Forming Bacteriocins Klebicins

(2019) Erna Denkovskienė et al.   Scientific Reports

Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis

(2018) Evelina Tacconelli et al.   LANCET INFECTIOUS DISEASES

The gut microbiome: Relationships with disease and opportunities for therapy

(2018) Juliana Durack et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors

(2017) Bertrand Routy et al.   SCIENCE

Elimination of Antibiotic Resistant Surgical Implant Biofilms Using an Engineered Cationic Amphipathic Peptide WLBU2

(2017) Jonathan B. Mandell et al.   Scientific Reports

What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention

(2016) John S. Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Anti-Gal: an abundant human natural antibody of multiple pathogeneses and clinical benefits

(2013) Uri Galili   IMMUNOLOGY

SASP gene delivery: A novel antibacterial approach

(2009) H. Fairhead   DRUG NEWS & PERSPECTIVES