Diethyl Succinate Modulates Microglial Polarization and Activation by Reducing Mitochondrial Fission and Cellular ROS

Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo

(2019) Syam Nair et al.   GLIA

Cathepsin C promotes microglia M1 polarization and aggravates neuroinflammation via activation of Ca2+-dependent PKC/p38MAPK/NF-κB pathway

(2019) Qing Liu et al.   Journal of Neuroinflammation

Mitochondrial fission requires DRP1 but not dynamins

(2019) Tiago Branco Fonseca et al.   NATURE

Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling

(2018) Yi-Tong Lu et al.   Cell Death & Disease

The Anti-neuroinflammatory Activity of Tectorigenin Pretreatment via Downregulated NF-κB and ERK/JNK Pathways in BV-2 Microglial and Microglia Inactivation in Mice With Lipopolysaccharide

(2018) Hye-Sun Lim et al.   Frontiers in Pharmacology

Brain-Resident Microglia and Blood-Borne Macrophages Orchestrate Central Nervous System Inflammation in Neurodegenerative Disorders and Brain Cancer

(2018) Lisa Sevenich   Frontiers in Immunology

Microglia and Beyond: Innate Immune Cells As Regulators of Brain Development and Behavioral Function

(2018) Kathryn M. Lenz et al.   Frontiers in Immunology

Structural basis of mitochondrial receptor binding and constriction by DRP1

(2018) Raghav Kalia et al.   NATURE

Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)

(2018) Starlee Lively et al.   Frontiers in Cellular Neuroscience

Succinate receptor mediates intestinal inflammation and fibrosis

(2018) Dulce C. Macias-Ceja et al.   Mucosal Immunology

The Role of Succinate in the Regulation of Intestinal Inflammation

(2018) Jessica Connors et al.   Nutrients

TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expression

(2018) Dominik C. Fuhrmann et al.   Redox Biology

Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

(2017) Yuqi Guo et al.   Nature Communications

Polymorphic regulation of mitochondrial fission and fusion modifies phenotypes of microglia in neuroinflammation

(2017) Mitsuhiko Katoh et al.   Scientific Reports

Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission

(2017) So Hee Ko et al.   Scientific Reports

Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

(2016) Laszlo Tretter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Peroxiredoxin 5 (Prx5) decreases LPS-induced microglial activation through regulation of Ca 2+ /calcineurin-Drp1-dependent mitochondrial fission

(2016) Junghyung Park et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis

(2016) Amanda Littlewood-Evans et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

(2016) Mousumi Ghosh et al.   Journal of Neuroinflammation

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cytosolic phospholipase A2 plays a crucial role in ROS/NO signaling during microglial activation through the lipoxygenase pathway

(2015) Dennis Y. Chuang et al.   Journal of Neuroinflammation

Carboxylic Acid Fullerene (C60) Derivatives Attenuated Neuroinflammatory Responses by Modulating Mitochondrial Dynamics

(2015) Shefang Ye et al.   Nanoscale Research Letters

Redox regulation of NF-κB p50 and M1 polarization in microglia

(2014) Thomas Taetzsch et al.   GLIA

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Disturbed mitochondrial dynamics and neurodegenerative disorders

(2014) Florence Burté et al.   Nature Reviews Neurology

Mitochondrial dynamics modulate the expression of pro-inflammatory mediators in microglial cells

(2013) Junghyung Park et al.   JOURNAL OF NEUROCHEMISTRY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Succinate: a metabolic signal in inflammation

(2013) Evanna Mills et al.   TRENDS IN CELL BIOLOGY

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

(2012) Zhigao Wang et al.   CELL

Succinate Receptors in the Kidney

(2011) P. M. T. Deen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Disorders caused by deficiency of succinate-CoA ligase

(2008) E. Ostergaard   JOURNAL OF INHERITED METABOLIC DISEASE

Triggering the succinate receptor GPR91 on dendritic cells enhances immunity

(2008) Tina Rubic et al.   NATURE IMMUNOLOGY