An Introduction to Bacterial Biofilms and Their Proteases, and Their Roles in Host Infection and Immune Evasion

An engineered protein-based submicromolar competitive inhibitor of the Staphylococcus aureus virulence factor aureolysin

(2022) Soraia R. Mendes et al.   Computational and Structural Biotechnology Journal

Neisseria meningitidis IgA1-specific serine protease exhibits novel cleavage activity against IgG3

(2021) Christian Spoerry et al.   Virulence

Bacillus subtilis biofilm formation and social interactions

(2021) Sofia Arnaouteli et al.   NATURE REVIEWS MICROBIOLOGY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice

(2021) Yajie Zhu et al.   Journal of Inflammation Research

Proteolytic Profiling of Streptococcal Pyrogenic Exotoxin B (SpeB) by Complementary HPLC-MS Approaches

(2021) Constantin Blöchl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Role of Streptococcal Cell-Envelope Proteases in Bacterial Evasion of the Innate Immune System

(2021) Sophie McKenna et al.   Journal of Innate Immunity

Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis

(2021) Bastiaan L. Duivelshof et al.   Pharmaceutics

Staphylococci evade the innate immune response by disarming neutrophils and forming biofilms

(2020) Lisanne de Vor et al.   FEBS LETTERS

An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses

(2020) Jordan L. Woehl et al.   ACS Chemical Biology

Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli

(2020) Lixia Liu et al.   Scientific Reports

Towards middle-up analysis of polyclonal antibodies: subclass-specific N-glycosylation profiling of murine immunoglobulin G (IgG) by means of HPLC-MS

(2020) Constantin Blöchl et al.   Scientific Reports

Microbial Biofilms: Human T-cell Leukemia Virus Type 1 First in Line for Viral Biofilm but Far Behind Bacterial Biofilms

(2020) Yousef Maali et al.   Frontiers in Microbiology

Distributions of Extracellular Peptidases Across Prokaryotic Genomes Reflect Phylogeny and Habitat

(2019) Trang T. H. Nguyen et al.   Frontiers in Microbiology

Metabolic Remodeling during Biofilm Development of Bacillus subtilis

(2019) Tippapha Pisithkul et al.   mBio

Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions

(2019) Urszula Zarzecka et al.   Frontiers in Microbiology

Anti-biofilm and antimicrobial effects of zerumbone against Bacteroides fragilis

(2019) Hye-Rim Kim et al.   ANAEROBE

The Pseudomonas aeruginosa lectin LecB binds to the exopolysaccharide Psl and stabilizes the biofilm matrix

(2019) Daniel Passos da Silva et al.   Nature Communications

Microbial Proteases Applications

(2019) Abdul Razzaq et al.   Frontiers in Bioengineering and Biotechnology

Identification and characterization of OmpT‐like proteases in uropathogenic Escherichia coli clinical isolates

(2019) Isabelle Desloges et al.   MicrobiologyOpen

The E-Cadherin Cleavage Associated to Pathogenic Bacteria Infections Can Favor Bacterial Invasion and Transmigration, Dysregulation of the Immune Response and Cancer Induction in Humans

(2019) Christian A. Devaux et al.   Frontiers in Microbiology

Chaperone activity of serine protease HtrA of Helicobacter pylori as a crucial survival factor under stress conditions

(2019) Urszula Zarzecka et al.   Cell Communication and Signaling

The End of an Era: Withdrawal of Xiapex (Clostridium histolyticum Collagenase) from the European Market

(2019) Andrea Cocci et al.   EUROPEAN UROLOGY

IdeS (Imlifidase)

(2018) Bonnie E. Lonze et al.   ANNALS OF SURGERY

Extracellular proteases of Staphylococcus epidermidis : roles as virulence factors and their participation in biofilm

(2018) Sergio Martínez-García et al.   APMIS

Bacterial biofilm and associated infections

(2018) Muhsin Jamal et al.   Journal of the Chinese Medical Association

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

(2018) Priti Saxena et al.   INDIAN JOURNAL OF MICROBIOLOGY

What are the advantages of living in a community? A microbial biofilm perspective!

(2018) André Luis Souza dos Santos et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Microbial Extracellular Polymeric Substances: Ecological Function and Impact on Soil Aggregation

(2018) Ohana Y. A. Costa et al.   Frontiers in Microbiology

Distinctive Roles for Periplasmic Proteases in the Maintenance of Essential Outer Membrane Protein Assembly

(2017) Garner R. Soltes et al.   JOURNAL OF BACTERIOLOGY

The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database

(2017) Neil D Rawlings et al.   NUCLEIC ACIDS RESEARCH

Discovery of a proteolytic flagellin family in diverse bacterial phyla that assembles enzymatically active flagella

(2017) Ulrich Eckhard et al.   Nature Communications

Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori

(2017) Aileen Harrer et al.   Gut Pathogens

Staphylococcus aureus Manipulates Innate Immunity through Own and Host-Expressed Proteases

(2017) Giampiero Pietrocola et al.   Frontiers in Cellular and Infection Microbiology

The immune system

(2016) L. B. Nicholson   Essays in Biochemistry

Amyloid Structures as Biofilm Matrix Scaffolds

(2016) Agustina Taglialegna et al.   JOURNAL OF BACTERIOLOGY

Biofilms: an emergent form of bacterial life

(2016) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Genomic Diversity of Enterotoxigenic Strains of Bacteroides fragilis

(2016) Jessica V. Pierce et al.   PLoS One

Biofilm Morphotypes and Population Structure among Staphylococcus epidermidis from Commensal and Clinical Samples

(2016) Llinos G. Harris et al.   PLoS One

The Role of Bacterial Secretion Systems in the Virulence of Gram-Negative Airway Pathogens Associated with Cystic Fibrosis

(2016) Sofie Depluverez et al.   Frontiers in Microbiology

Potential Emergence of Multi-quorum Sensing Inhibitor Resistant (MQSIR) Bacteria

(2015) Shikha Koul et al.   INDIAN JOURNAL OF MICROBIOLOGY

The Serine Protease Pic From Enteroaggregative Escherichia coli Mediates Immune Evasion by the Direct Cleavage of Complement Proteins

(2015) Afonso G. Abreu et al.   JOURNAL OF INFECTIOUS DISEASES

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

(2015) Tiago R. D. Costa et al.   NATURE REVIEWS MICROBIOLOGY

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Network Analyses Reveal Pervasive Functional Regulation Between Proteases in the Human Protease Web

(2014) Nikolaus Fortelny et al.   PLOS BIOLOGY

Staphylococcus aureus biofilms: recent developments in biofilm dispersal

(2014) Jessica L. Lister et al.   Frontiers in Cellular and Infection Microbiology

The Tat system of Gram-positive bacteria

(2013) Vivianne J. Goosens et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Rapid IgG heavy chain cleavage by the streptococcal IgG endopeptidase IdeS is mediated by IdeS monomers and is not due to enzyme dimerization

(2013) Reine Vindebro et al.   FEBS LETTERS

Role of uropathogenicEscherichia coliOmpT in the resistance against human cathelicidin LL-37

(2013) John R. Brannon et al.   FEMS MICROBIOLOGY LETTERS

Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T

(2013) Ulrich Eckhard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted Proteases Control Autolysin-mediated Biofilm Growth ofStaphylococcus aureus

(2013) Chen Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture and function of metallopeptidase catalytic domains

(2013) Núria Cerdà-Costa et al.   PROTEIN SCIENCE

Microanatomy at Cellular Resolution and Spatial Order of Physiological Differentiation in a Bacterial Biofilm

(2013) D. O. Serra et al.   mBio

Pathogenesis of Meningococcemia

(2013) M. Coureuil et al.   Cold Spring Harbor Perspectives in Medicine

Protease-dependent mechanisms of complement evasion by bacterial pathogens

(2012) Michal Potempa et al.   BIOLOGICAL CHEMISTRY

Bacterial proteolytic complexes as therapeutic targets

(2012) Ravikiran M. Raju et al.   NATURE REVIEWS DRUG DISCOVERY

Treatment of Hyperhidrosis With Botulinum Toxin

(2012) M. A. Doft et al.   Aesthetic Surgery Journal

Bap, a Biofilm Matrix Protein of Staphylococcus aureus Prevents Cellular Internalization through Binding to GP96 Host Receptor

(2012) Jaione Valle et al.   PLoS Pathogens

Role of Intracellular Proteases in the Antibiotic Resistance, Motility, and Biofilm Formation of Pseudomonas aeruginosa

(2011) Lucía Fernández et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Role of Exopolysaccharides in Pseudomonas aeruginosa Biofilm Formation and Architecture

(2011) Aamir Ghafoor et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Proteases as therapeutics

(2011) Charles S. Craik et al.   BIOCHEMICAL JOURNAL

Influence of Enzymatic Hydrolysis on the Allergenicity of Roasted Peanut Protein Extract

(2011) Beatriz Cabanillas et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Extracellular DNA in Biofilms

(2011) Lucio Montanaro et al.   INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS

The Role of Antimicrobial Peptides in Preventing Multidrug-Resistant Bacterial Infections and Biofilm Formation

(2011) Seong-Cheol Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Staphylococcus aureus Metalloprotease Aureolysin Cleaves Complement C3 To Mediate Immune Evasion

(2011) A. J. Laarman et al.   JOURNAL OF IMMUNOLOGY

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis

(2011) Ulrich Eckhard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure, function and latency regulation of a bacterial enterotoxin potentially derived from a mammalian adamalysin/ADAM xenolog

(2011) Theodoros Goulas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The expanding scope of antimicrobial peptide structures and their modes of action

(2011) Leonard T. Nguyen et al.   TRENDS IN BIOTECHNOLOGY

The clinical impact of bacterial biofilms

(2011) Niels Høiby et al.   International Journal of Oral Science

Identification and characterization of a bacterial glutamic peptidase

(2010) Kenneth Jensen et al.   BMC BIOCHEMISTRY

The complement system

(2010) J. Vidya Sarma et al.   CELL AND TISSUE RESEARCH

Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

(2010) Benjamin Hoy et al.   EMBO REPORTS

EspP, a Serine Protease of Enterohemorrhagic Escherichia coli, Impairs Complement Activation by Cleaving Complement Factors C3/C3b and C5

(2010) D. Orth et al.   INFECTION AND IMMUNITY

Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses

(2010) J.B. Kaplan   JOURNAL OF DENTAL RESEARCH

The biofilm matrix

(2010) Hans-Curt Flemming et al.   NATURE REVIEWS MICROBIOLOGY

Botulinum toxin

(2010) PK Nigam et al.   INDIAN JOURNAL OF DERMATOLOGY

Protein secretion systems in bacterial-host associations, and their description in the Gene Ontology

(2009) Tsai-Tien Tseng et al.   BMC MICROBIOLOGY

Complement and its role in innate and adaptive immune responses

(2009) Jason R Dunkelberger et al.   CELL RESEARCH

The Pic Protease of Enteroaggregative Escherichia coli Promotes Intestinal Colonization and Growth in the Presence of Mucin

(2009) S. M. Harrington et al.   INFECTION AND IMMUNITY

Induction of Persistent Colitis by a Human Commensal, Enterotoxigenic Bacteroides fragilis, in Wild-Type C57BL/6 Mice

(2009) K.-J. Rhee et al.   INFECTION AND IMMUNITY

Injectable Collagenase Clostridium Histolyticum for Dupuytren's Contracture

(2009) Lawrence C. Hurst et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

(2009) R. J. Brezski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing

(2008) Annelies S. Zinkernagel et al.   Cell Host & Microbe

Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation

(2008) J. Overhage et al.   INFECTION AND IMMUNITY

Microbial IgA Protease Removes IgA Immune Complexes from Mouse Glomeruli In Vivo: Potential Therapy for IgA Nephropathy

(2007) Michael E. Lamm et al.   AMERICAN JOURNAL OF PATHOLOGY

Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—Distinct translocases and mechanisms

(2007) Paolo Natale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES