Strong Expansion of Human Regulatory T Cells for Adoptive Cell Therapy Results in Epigenetic Changes Which May Impact Their Survival and Function

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells

(2021) Michael Delacher et al.   IMMUNITY

Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling

(2021) Evan W. Weber et al.   SCIENCE

Dynamic chromatin regulatory landscape of human CAR T cell exhaustion

(2021) David G. Gennert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis reveals the association between alternative splicing and DNA methylation across human solid tumors

(2020) Xiaohui Sun et al.   BMC Medical Genomics

Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases

(2020) Naganari Ohkura et al.   IMMUNITY

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

(2020) Hossam A. Abdelsamed et al.   NATURE IMMUNOLOGY

Characterization of universal features of partially methylated domains across tissues and species

(2020) Benjamin E. Decato et al.   Epigenetics & Chromatin

Regulatory T cells for minimising immune suppression in kidney transplantation: phase I/IIa clinical trial

(2020) Andy Roemhild et al.   BMJ-British Medical Journal

Cellular senescence and senescence-associated secretory phenotype: comparison of idiopathic pulmonary fibrosis, connective tissue disease-associated interstitial lung disease, and chronic obstructive pulmonary disease

(2019) Ryo Okuda et al.   Journal of Thoracic Disease

Methods to manufacture regulatory T cells for cell therapy

(2019) Katherine N. MacDonald et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulatory T cells: the future of autoimmune disease treatment

(2019) Monika Ryba-Stanisławowska et al.   Expert Review of Clinical Immunology

TOX is a critical regulator of tumour-specific T cell differentiation

(2019) Andrew C. Scott et al.   NATURE

TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

(2019) Omar Khan et al.   NATURE

Graft Engineering and Adoptive Immunotherapy: New Approaches to Promote Immune Tolerance After Hematopoietic Stem Cell Transplantation

(2019) Alice Bertaina et al.   Frontiers in Immunology

Therapeutic use of regulatory T cells for graft‐versus‐host disease

(2019) Shlomo Elias et al.   BRITISH JOURNAL OF HAEMATOLOGY

Stability and inhibitory function of Treg cells under inflammatory conditions in�vitro

(2019) Huifang Guo et al.   Experimental and Therapeutic Medicine

CD4+FOXP3+ Regulatory T Cell Therapies in HLA Haploidentical Hematopoietic Transplantation

(2019) Antonella Mancusi et al.   Frontiers in Immunology

Novel effector phenotype of Tim-3+ regulatory T cells leads to enhanced suppressive function in head and neck cancer patients

(2018) Zhuqing Liu et al.   CLINICAL CANCER RESEARCH

DNA methylation loss in late-replicating domains is linked to mitotic cell division

(2018) Wanding Zhou et al.   NATURE GENETICS

Consistent inverse correlation between DNA methylation of the first intron and gene expression across tissues and species

(2018) Dafni Anastasiadi et al.   Epigenetics & Chromatin

Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

(2018) Anke Fuchs et al.   Frontiers in Immunology

Clinical Grade Regulatory CD4+ T Cells (Tregs): Moving Toward Cellular-Based Immunomodulatory Therapies

(2018) Richard Duggleby et al.   Frontiers in Immunology

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

(2018) Henrieta Fraser et al.   Molecular Therapy-Methods & Clinical Development

Emerging Cellular Therapies for Cancer

(2018) Sonia Guedan et al.   Annual Review of Immunology

Regulatory T cells in the treatment of disease

(2018) Amir Sharabi et al.   NATURE REVIEWS DRUG DISCOVERY

A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability

(2018) Mahdieh Jadaliha et al.   PLoS Genetics

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

(2017) Hossam A. Abdelsamed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

H3K27 Methylation Dynamics during CD4 T Cell Activation: Regulation of JAK/STAT and IL12RB2 Expression by JMJD3

(2017) Sarah A. LaMere et al.   JOURNAL OF IMMUNOLOGY

CD45RA Distinguishes CD4+CD25+CD127−/low TSDR Demethylated Regulatory T Cell Subpopulations With Differential Stability and Susceptibility to Tacrolimus-Mediated Inhibition of Suppression

(2017) Rebeca Arroyo Hornero et al.   TRANSPLANTATION

Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells

(2017) Xuehui He et al.   Scientific Reports

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells

(2016) Meromit Singer et al.   CELL

Promoter H3K4 methylation dynamically reinforces activation-induced pathways in human CD4 T cells

(2016) S A LaMere et al.   GENES AND IMMUNITY

Epigenomic Profiling of Human CD4 + T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development

(2016) Pawel Durek et al.   IMMUNITY

Instability of Helios-deficient Tregs is associated with conversion to a T-effector phenotype and enhanced antitumor immunity

(2016) Hidetoshi Nakagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade

(2016) K. E. Pauken et al.   SCIENCE

Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks

(2016) Anne Schellenberg et al.   Aging-US

ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization

(2015) Guangchuang Yu et al.   BIOINFORMATICS

TIGIT predominantly regulates the immune response via regulatory T cells

(2015) Sema Kurtulus et al.   JOURNAL OF CLINICAL INVESTIGATION

Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226

(2015) Christopher A. Fuhrman et al.   JOURNAL OF IMMUNOLOGY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Hurdles in therapy with regulatory T cells

(2015) Piotr Trzonkowski et al.   Science Translational Medicine

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

Distinct Epigenetic Signatures Delineate Transcriptional Programs during Virus-Specific CD8+ T Cell Differentiation

(2014) Brendan E. Russ et al.   IMMUNITY

T Cell Replicative Senescence in Human Aging

(2013) Jennifer P. Chou et al.   CURRENT PHARMACEUTICAL DESIGN

Dynamic DNA methylation across diverse human cell lines and tissues

(2013) K. E. Varley et al.   GENOME RESEARCH

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

(2013) Samantha L. Bailey-Bucktrout et al.   IMMUNITY

Using epigenetics to define vaccine-induced memory T cells

(2013) Ben Youngblood et al.   Current Opinion in Virology

TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer

(2013) Kaori Sakuishi et al.   OncoImmunology

The sva package for removing batch effects and other unwanted variation in high-throughput experiments

(2012) Jeffrey T. Leek et al.   BIOINFORMATICS

Immune aging and autoimmunity

(2012) Jörg J. Goronzy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs

(2012) Shipra Gupta et al.   JOURNAL OF CLINICAL INVESTIGATION

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Human regulatory T cells in allogeneic stem cell transplantation

(2011) S. N. Ukena et al.   BLOOD

The Time is Crucial for Ex Vivo Expansion of T Regulatory Cells for Therapy

(2011) Natalia Marek et al.   CELL TRANSPLANTATION

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

(2011) G. C. Hon et al.   GENOME RESEARCH

Essential Role for Retinoic Acid in the Promotion of CD4+ T Cell Effector Responses via Retinoic Acid Receptor Alpha

(2011) Jason A. Hall et al.   IMMUNITY

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

(2011) Ryan Lister et al.   NATURE

Massive ex Vivo Expansion of Human Natural Regulatory T Cells (Tregs) with Minimal Loss of in Vivo Functional Activity

(2011) K. L. Hippen et al.   Science Translational Medicine

RhoH modulates pre-TCR and TCR signalling by regulating LCK

(2010) Hong Wang et al.   CELLULAR SIGNALLING

Loss of FOXP3 expression in natural human CD4+CD25+regulatory T cells upon repetitivein vitrostimulation

(2009) Petra Hoffmann et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CD59 Blockade Enhances Antigen-Specific CD4+ T Cell Responses in Humans: A New Target for Cancer Immunotherapy?

(2009) B. Sivasankar et al.   JOURNAL OF IMMUNOLOGY

Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function

(2009) Maciej Kmieciak et al.   Journal of Translational Medicine

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

(2009) Madeleine P Ball et al.   NATURE BIOTECHNOLOGY