Spatial structure governs the mode of tumour evolution

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

(2021) Stefan C. Dentro et al.   CELL

Breast tumours maintain a reservoir of subclonal diversity during expansion

(2021) Darlan C. Minussi et al.   NATURE

Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment

(2021) Min Zhang et al.   Nature Communications

A theoretical analysis of tumour containment

(2021) Yannick Viossat et al.   Nature Ecology & Evolution

Paracrine Behaviors Arbitrate Parasite-Like Interactions Between Tumor Subclones

(2021) Robert J. Noble et al.   Frontiers in Ecology and Evolution

Extensive clonal branching shapes the evolutionary history of high-risk pediatric cancers

(2020) Natalie Andersson et al.   CANCER RESEARCH

The single-cell pathology landscape of breast cancer

(2020) Hartland W. Jackson et al.   NATURE

The evolutionary history of 2,658 cancers

(2020) Moritz Gerstung et al.   NATURE

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

(2020) Michael A. Durante et al.   Nature Communications

Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

(2020) Katharina von Loga et al.   Nature Communications

Minimal barriers to invasion during human colorectal tumor growth

(2020) Marc D. Ryser et al.   Nature Communications

When, why and how tumour clonal diversity predicts survival

(2020) Robert Noble et al.   Evolutionary Applications

Tumour budding in solid cancers

(2020) Alessandro Lugli et al.   Nature Reviews Clinical Oncology

Fibroadenomas: a multidisciplinary review of the variants

(2020) Isil Basara Akin et al.   CLINICAL IMAGING

Patterns of Tumor Progression Predict Small and Tissue-Specific Tumor-Originating Niches

(2019) Thomas Buder et al.   Frontiers in Oncology

Resolving genetic heterogeneity in cancer

(2019) Samra Turajlic et al.   NATURE REVIEWS GENETICS

Crypt fusion as a homeostatic mechanism in the human colon

(2019) Ann-Marie Baker et al.   GUT

Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data

(2019) Ketevan Chkhaidze et al.   PLoS Computational Biology

Inferring Tumour Proliferative Organisation from Phylogenetic Tree Measures in a Computational Model

(2019) Jacob G Scott et al.   SYSTEMATIC BIOLOGY

Architectural Patterns are a Relevant Morphologic Grading System for Clear Cell Renal Cell Carcinoma Prognosis Assessment

(2018) Jérôme Verine et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies

(2018) Jill A. Gallaher et al.   CANCER RESEARCH

Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal

(2018) Samra Turajlic et al.   CELL

Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium

(2018) Anna M. Nicholson et al.   Cell Stem Cell

Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer

(2018) Jenny Karlsson et al.   NATURE GENETICS

Quantification of subclonal selection in cancer from bulk sequencing data

(2018) Marc J. Williams et al.   NATURE GENETICS

Spatial mutation patterns as markers of early colorectal tumor cell mobility

(2018) Marc D. Ryser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The evolutionary landscape of colorectal tumorigenesis

(2018) William Cross et al.   Nature Ecology & Evolution

Range Expansion Theories Could Shed Light on the Spatial Structure of Intra-tumour Heterogeneity

(2018) Cindy Gidoin et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Neutral tumor evolution?

(2018) Maxime Tarabichi et al.   NATURE GENETICS

Intratumor Heterogeneity and Circulating Tumor Cell Clusters

(2017) Zafarali Ahmed et al.   MOLECULAR BIOLOGY AND EVOLUTION

Between-region genetic divergence reflects the mode and tempo of tumor evolution

(2017) Ruping Sun et al.   NATURE GENETICS

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Tracking the Evolution of Non–Small-Cell Lung Cancer

(2017) Mariam Jamal-Hanjani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing

(2017) L. Rasche et al.   Nature Communications

Spatial competition constrains resistance to targeted cancer therapy

(2017) Katarina Bacevic et al.   Nature Communications

Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma

(2017) Eirini Pectasides et al.   Cancer Discovery

Big Bang Tumor Growth and Clonal Evolution

(2017) Ruping Sun et al.   Cold Spring Harbor Perspectives in Medicine

QuPath: Open source software for digital pathology image analysis

(2017) Peter Bankhead et al.   Scientific Reports

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer

(2016) Yuka Suzuki et al.   Molecular Oncology

Modes of invasion during tumour dissemination

(2016) Pahini Pandya et al.   Molecular Oncology

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

(2016) Andrew McPherson et al.   NATURE GENETICS

Identification of neutral tumor evolution across cancer types

(2016) Marc J Williams et al.   NATURE GENETICS

Early and multiple origins of metastatic lineages within primary tumors

(2016) Zi-Ming Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity

(2016) Rouven Hoefflin et al.   Nature Communications

Histopathology of hepatocellular carcinoma

(2016) Manuel Schlageter et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Spatial Moran models, II: cancer initiation in spatially structured tissue

(2015) R. Durrett et al.   JOURNAL OF MATHEMATICAL BIOLOGY

A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity

(2015) Bartlomiej Waclaw et al.   NATURE

Spatial genomic heterogeneity within localized, multifocal prostate cancer

(2015) Paul C Boutros et al.   NATURE GENETICS

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

(2015) Colin S Cooper et al.   NATURE GENETICS

A Big Bang model of human colorectal tumor growth

(2015) Andrea Sottoriva et al.   NATURE GENETICS

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

(2015) Lucy R Yates et al.   NATURE MEDICINE

Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution

(2015) Shaoping Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

(2014) Marco Gerlinger et al.   NATURE GENETICS

Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing

(2014) J. Zhang et al.   SCIENCE

Growth Pattern, an Important Pathologic Prognostic Parameter for Clear Cell Renal Cell Carcinoma

(2013) Akitoshi Fukatsu et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new balance index for phylogenetic trees

(2012) Arnau Mir et al.   MATHEMATICAL BIOSCIENCES

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genealogies of rapidly adapting populations

(2012) R. A. Neher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

(2010) Hugo J. Snippert et al.   CELL

Accumulation of driver and passenger mutations during tumor progression

(2010) I. Bozic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 β-1,6-N-acetylglusaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas

(2009) Catherine A St Hill et al.   BMC CANCER

Gene surfing in expanding populations

(2007) Oskar Hallatschek et al.   THEORETICAL POPULATION BIOLOGY