Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting

Nanomaterials for T-cell cancer immunotherapy

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Label-Free Multivariate Biophysical Phenotyping-Activated Acoustic Sorting at the Single-Cell Level

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What does cell therapy manufacturing cost? A framework and methodology to facilitate academic and other small-scale cell therapy manufacturing costings

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Evaluation of Single-Cell Cytokine Secretion and Cell-Cell Interactions with a Hierarchical Loading Microwell Chip

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Ultrasensitive and rapid quantification of rare tumorigenic stem cells in hPSC-derived cardiomyocyte populations

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Evaluating different adoption scenarios for TIL-therapy and the influence on its (early) cost-effectiveness

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Ultrahigh-throughput magnetic sorting of large blood volumes for epitope-agnostic isolation of circulating tumor cells

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Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer

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CD39 identifies the CD4+ tumor-specific T cell population in human cancer

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Future role for adoptive T-cell therapy in checkpoint inhibitor-resistant metastatic melanoma

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Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting

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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

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DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

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Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

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High-throughput dielectrophoretic cell sorting assisted by cell sliding on scalable electrode tracks made of conducting-PDMS

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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

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Considerations for high-yield, high-throughput cell enrichment: fluorescence versus magnetic sorting

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Isolation of B-cells using Miltenyi MACS bead isolation kits

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

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A flyover style microfluidic chip for highly purified magnetic cell separation

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Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

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Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer

(2019) James Clarke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

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Pursuit of tumor-infiltrating lymphocyte immunotherapy speeds up

(2019) Ken Garber   NATURE BIOTECHNOLOGY

Tumor infiltrating lymphocytes expanded from pediatric neuroblastoma display heterogeneity of phenotype and function

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High-throughput genome-wide phenotypic screening via immunomagnetic cell sorting

(2019) Barbara Mair et al.   Nature Biomedical Engineering

TCF-1-Centered Transcriptional Network Drives an Effector versus Exhausted CD8 T Cell-Fate Decision

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Developing neoantigen-targeted T cell–based treatments for solid tumors

(2019) Tori N. Yamamoto et al.   NATURE MEDICINE

Intratumoral CD8+ T cells with stem cell–like properties: Implications for cancer immunotherapy

(2019) Werner Held et al.   Science Translational Medicine

Cell Separations and Sorting

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An intra-tumoral niche maintains and differentiates stem-like CD8 T cells

(2019) Caroline S. Jansen et al.   NATURE

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

(2018) Xinyi Guo et al.   NATURE MEDICINE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

(2018) Coleman Murray et al.   LAB ON A CHIP

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response

(2018) Peng Jiang et al.   NATURE MEDICINE

A phase II study of tumor-infiltrating lymphocyte therapy for human papillomavirus-associated epithelial cancers

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Adoptive transfer of tumor-infiltrating lymphocytes in melanoma: a viable treatment option

(2018) Maartje W. Rohaan et al.   Journal for ImmunoTherapy of Cancer

IL-2hightissue-resident T cells in the human liver: Sentinels for hepatotropic infection

(2017) Laura J. Pallett et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Micro vapor bubble jet flow for safe and high-rate fluorescence-activated cell sorting

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Microfluidic fluorescence-activated cell sorting (μFACS) chip with integrated piezoelectric actuators for low-cost mammalian cell enrichment

(2017) Zhen Cheng et al.   Microfluidics and Nanofluidics

High-throughput, low-loss, low-cost, and label-free cell separation using electrophysiology-activated cell enrichment

(2017) Shabnam A. Faraghat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of tumor-infiltrating lymphocytes and their potential for application as adoptive cell transfer therapy in human breast cancer

(2017) Hee Jin Lee et al.   Oncotarget

Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation

(2017) Sivan Seliktar-Ofir et al.   Frontiers in Immunology

Chimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications

(2017) Hamid R. Mirzaei et al.   Frontiers in Immunology

High-Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells

(2017) Eric Lin et al.   Cell Systems

Monolithic Chip for High-throughput Blood Cell Depletion to Sort Rare Circulating Tumor Cells

(2017) Fabio Fachin et al.   Scientific Reports

Long-Lasting Complete Responses in Patients with Metastatic Melanoma after Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes and an Attenuated IL2 Regimen

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Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Regulation of the T Cell Response by CD39

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The 2nd meeting of the Campania Society of Oncology Immunotherapy (SCITO): focus on hepatocellular carcinoma, kidney and bladder cancer

(2016) Bruno Daniele et al.   Journal for ImmunoTherapy of Cancer

Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells

(2016) Godehard Scholz et al.   EBioMedicine

Acoustofluidic Fluorescence Activated Cell Sorter

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CD73 and CD39 ectonucleotidases in T cell differentiation: Beyond immunosuppression

(2015) María Rosa Bono et al.   FEBS LETTERS

In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

(2015) Luca Biasco et al.   Science Translational Medicine

A phase I clinical trial combining dendritic cell vaccination with adoptive T cell transfer in patients with stage IV melanoma

(2014) Isabel Poschke et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD39 is a negative regulator of P2X7-mediated inflammatory cell death in mast cells

(2014) Marcel Kuhny et al.   Cell Communication and Signaling

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

Disordered purinergic signaling and abnormal cellular metabolism are associated with development of liver cancer inCd39/Entpd1null Mice

(2012) Xiaofeng Sun et al.   HEPATOLOGY

A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity

(2011) Qingsheng Li et al.   IMMUNITY

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Cell transfer immunotherapy for metastatic solid cancer—what clinicians need to know

(2011) Steven A. Rosenberg   Nature Reviews Clinical Oncology

Large scale expansion of Vγ9Vδ2 T lymphocytes from human peripheral blood mononuclear cells after a positive selection using MACS “TCR γ/δ + T cell isolation kit”

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Detection and Functional Analysis of Tumor Infiltrating T-Lymphocytes (TIL) in Liver Metastases from Colorectal Cancer

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