In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells

B-cell development and functions and therapeutic options in adenosine deaminase–deficient patients

(2014) Immacolata Brigida et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

Lineage relationship of effector and memory T cells

(2013) Nicholas P Restifo et al.   CURRENT OPINION IN IMMUNOLOGY

Mechanisms of Retroviral Integration and Mutagenesis

(2013) Alessia Cavazza et al.   HUMAN GENE THERAPY

T-cell memory differentiation: insights from transcriptional signatures and epigenetics

(2013) Ben Youngblood et al.   IMMUNOLOGY

Superior T memory stem cell persistence supports long-lived T cell memory

(2013) Enrico Lugli et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: The Signals for the Generation of T Cell Memory Are Qualitatively Different Depending on TCR Ligand Strength

(2013) K. M. Knudson et al.   JOURNAL OF IMMUNOLOGY

Disparate Individual Fates Compose Robust CD8+ T Cell Immunity

(2013) V. R. Buchholz et al.   SCIENCE

Heterogeneous Differentiation Patterns of Individual CD8+ T Cells

(2013) C. Gerlach et al.   SCIENCE

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

(2013) A. Aiuti et al.   SCIENCE

Lentiviral Hematopoietic Stem Cell Gene Therapy Benefits Metachromatic Leukodystrophy

(2013) A. Biffi et al.   SCIENCE

IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors

(2012) N. Cieri et al.   BLOOD

Gene therapy for adenosine deaminase-deficient severe combined immune deficiency: clinical comparison of retroviral vectors and treatment plans

(2012) F. Candotti et al.   BLOOD

Integration of retroviral vectors

(2012) Richard Gabriel et al.   CURRENT OPINION IN IMMUNOLOGY

Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations

(2012) Daniela Cesana et al.   JOURNAL OF CLINICAL INVESTIGATION

Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts

(2012) Arianna Moiani et al.   JOURNAL OF CLINICAL INVESTIGATION

Retroviral Integrations in Gene Therapy Trials

(2012) Luca Biasco et al.   MOLECULAR THERAPY

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

Parachuting in the epigenome: the biology of gene vector insertion profiles in the context of clinical trials

(2011) Christopher Baum   EMBO Molecular Medicine

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Ex vivo gene transfer and correction for cell-based therapies

(2011) Luigi Naldini   NATURE REVIEWS GENETICS

Hematopoietic Stem Cell Gene Therapy for Adenosine Deaminase-Deficient Severe Combined Immunodeficiency Leads to Long-Term Immunological Recovery and Metabolic Correction

(2011) H. B. Gaspar et al.   Science Translational Medicine

Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell

(2010) Luca Biasco et al.   EMBO Molecular Medicine

Role of reduced intensity conditioning in T-cell and B-cell immune reconstitution after HLA-identical bone marrow transplantation in ADA-SCID

(2010) C. Cancrini et al.   HAEMATOLOGICA

The Different Extent of B and T Cell Immune Reconstitution after Hematopoietic Stem Cell Transplantation and Enzyme Replacement Therapies in SCID Patients with Adenosine Deaminase Deficiency

(2010) F. Serana et al.   JOURNAL OF IMMUNOLOGY

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

Massively parallel pyrosequencing in HIV research

(2009) Frederic D Bushman et al.   AIDS

Long-term outcome after hematopoietic stem cell transplantation of a single-center cohort of 90 patients with severe combined immunodeficiency

(2009) B. Neven et al.   BLOOD

How I treat ADA deficiency

(2009) H. B. Gaspar et al.   BLOOD

Diversity in T Cell Memory: An Embarrassment of Riches

(2009) Stephen C. Jameson et al.   IMMUNITY

The Yellow Fever Virus Vaccine Induces a Broad and Polyfunctional Human Memory CD8+ T Cell Response

(2009) R. S. Akondy et al.   JOURNAL OF IMMUNOLOGY

Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency

(2009) Alessandro Aiuti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Resistance of mature T cells to oncogene transformation

(2008) S. Newrzela et al.   BLOOD

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

(2008) Steven J. Howe et al.   JOURNAL OF CLINICAL INVESTIGATION