Protective effect of isoflavones and triterpenoid saponins from pueraria lobata on liver diseases: A review

Isoflavones

(2019) Ludmila Křížová et al.   MOLECULES

Formononetin ameliorates cholestasis by regulating hepatic SIRT1 and PPARα

(2019) Shu Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Formononetin alleviates hepatic steatosis by facilitating TFEB-mediated lysosome biogenesis and lipophagy

(2019) Yan Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

A cross-sectional study of the public health response to non-alcoholic fatty liver disease in Europe

(2019) Jeffrey V. Lazarus et al.   JOURNAL OF HEPATOLOGY

Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK

(2019) Roger Williams et al.   LANCET

The effects of heavy metals on human metabolism

(2019) Zhushan Fu et al.   TOXICOLOGY MECHANISMS AND METHODS

Genistein Improves Liver Damage in Male Mice Exposed to Morphine

(2018) Cyrus Jalili et al.   CHINESE MEDICAL JOURNAL

Increasing Healthcare Burden of Chronic Liver Disease Compared to Other Chronic Diseases, 2004–2013

(2018) Sumeet K. Asrani et al.   GASTROENTEROLOGY

Disease burden and costs from excess alcohol consumption, obesity, and viral hepatitis: fourth report of the Lancet Standing Commission on Liver Disease in the UK

(2018) Roger Williams et al.   LANCET

Absolute oral bioavailability and disposition kinetics of puerarin in female rats

(2018) Tosapol Anukunwithaya et al.   BMC Pharmacology & Toxicology

Mechanism of combined use of vitamin D and puerarin in anti-hepatic fibrosis by regulating the Wnt/β-catenin signalling pathway

(2018) Gan-Rong Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Changing Trends in Etiology-Based Annual Mortality From Chronic Liver Disease, From 2007 Through 2016

(2018) Donghee Kim et al.   GASTROENTEROLOGY

Formononetin and biochanin A protects against ritonavir induced hepatotoxicity via modulation of NfκB/pAkt signaling molecules

(2018) Alauddin et al.   LIFE SCIENCES

Effect of Puerarin Regulated mTOR Signaling Pathway in Experimental Liver Injury

(2018) Bu-Gao Zhou et al.   Frontiers in Pharmacology

Saponins in pulses and their health promoting activities: A review

(2017) Balwinder Singh et al.   FOOD CHEMISTRY

Genistein improves schistosomiasis liver granuloma and fibrosis via dampening NF-kB signaling in mice

(2017) Chunpeng Wan et al.   PARASITOLOGY RESEARCH

Formononetin protects against acetaminophen-induced hepatotoxicity through enhanced NRF2 activity

(2017) Fen Jin et al.   PLoS One

The Pathology of Acute Liver Failure

(2016) Jay H. Lefkowitch   ADVANCES IN ANATOMIC PATHOLOGY

Daidzein: A review of pharmacological effects

(2016) Meng-Yao Sun et al.   African Journal of Traditional Complementary and Alternative Medicines

Puerarin protects mouse liver against nickel-induced oxidative stress and inflammation associated with the TLR4/p38/CREB pathway

(2016) Chan-Min Liu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Puerarin protects against CCl4-induced liver fibrosis in mice: possible role of PARP-1 inhibition

(2016) Shuai Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms

(2016) Liang Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Recent Advances in Methods of Puerarin Biotransformation

(2016) Guiyou Liu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Naturally Occurring Nrf2 Activators: Potential in Treatment of Liver Injury

(2016) Ravirajsinh N. Jadeja et al.   Oxidative Medicine and Cellular Longevity

Bioactivity of genistein: A review of in vitro and in vivo studies

(2015) Ajaz Ahmad Ganai et al.   BIOMEDICINE & PHARMACOTHERAPY

Alcoholic liver disease: mechanisms of injury and targeted treatment

(2015) Alexandre Louvet et al.   Nature Reviews Gastroenterology & Hepatology

Effects of a combination of puerarin, baicalin and berberine on the expression of proliferator-activated receptor-γ and insulin receptor in a rat model of nonalcoholic fatty liver disease

(2015) WEIHAN ZHAO et al.   Experimental and Therapeutic Medicine

Effects of Puerarin on Lipid Accumulation and Metabolism in High-Fat Diet-Fed Mice

(2015) Guodong Zheng et al.   PLoS One

Puerarin Attenuates Carbon Tetrachloride-Induced Liver Oxidative Stress and Hyperlipidaemia in Mouse by JNK/c-Jun/CYP7A1 Pathway

(2014) Jie-Qiong Ma et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Puerarin ameliorates carbon tetrachloride-induced oxidative DNA damage and inflammation in mouse kidney through ERK/Nrf2/ARE pathway

(2014) Jie-Qiong Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

Pueraria tuberosa: a review on its phytochemical and therapeutic potential

(2014) Amal K. Maji et al.   NATURAL PRODUCT RESEARCH

Puerarin induces the upregulation of glutathione levels and nuclear translocation of Nrf2 through PI3K/Akt/GSK-3β signaling events in PC12 cells exposed to lead

(2014) Chengchong Li et al.   NEUROTOXICOLOGY AND TERATOLOGY

Soyasaponins Prevent H2O2-Induced Inhibition of Gap Junctional Intercellular Communication by Scavenging Reactive Oxygen Species in Rat Liver Cells

(2014) Jiading Chen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Genistein Reinforces the Inhibitory Effect of Cisplatin on Liver Cancer Recurrence and Metastasis after Curative Hepatectomy

(2013) Peng Chen et al.   Asian Pacific Journal of Cancer Prevention

Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway

(2013) Chao Guo et al.   FOOD AND CHEMICAL TOXICOLOGY

Daidzein causes cytochrome c-mediated apoptosis via the Bcl-2 family in human hepatic cancer cells

(2013) Hyun Jin Park et al.   FOOD AND CHEMICAL TOXICOLOGY

Genistein protection against acetaminophen-induced liver injury via its potential impact on the activation of UDP-glucuronosyltransferase and antioxidant enzymes

(2013) Yuan-jing Fan et al.   FOOD AND CHEMICAL TOXICOLOGY

Glutathione is essential to preserve nuclear function and cell survival under oxidative stress

(2013) Elie Hatem et al.   FREE RADICAL BIOLOGY AND MEDICINE

Puerarin, isolated from Kudzu root (Willd.), attenuates hepatocellular cytotoxicity and regulates the GSK-3β/NF-κB pathway for exerting the hepatoprotection against chronic alcohol-induced liver injury in rats

(2013) Rong Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Role of Metallothionein in Oxidative Stress

(2013) Branislav Ruttkay-Nedecky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oral Toxicological Studies ofPuerariaFlower Extract: Acute Toxicity Study in Mice and Subchronic Toxicity Study in Rats

(2013) Akira Takano et al.   JOURNAL OF FOOD SCIENCE

The burden of liver disease in Europe: A review of available epidemiological data

(2013) Martin Blachier et al.   JOURNAL OF HEPATOLOGY

Autoimmune hepatitis in Denmark: Incidence, prevalence, prognosis, and causes of death. A nationwide registry-based cohort study

(2013) Lisbet Grønbæk et al.   JOURNAL OF HEPATOLOGY

Puerarin, isolated from Pueraria lobata (Willd.), protects against hepatotoxicity via specific inhibition of the TGF-β1/Smad signaling pathway, thereby leading to anti-fibrotic effect

(2013) Lingyuan Xu et al.   PHYTOMEDICINE

Puerarin improves metabolic function leading to hepatoprotective effects in chronic alcohol-induced liver injury in rats

(2013) Xu Chen et al.   PHYTOMEDICINE

Puerarin: A Review of Pharmacological Effects

(2013) Yan-Xi Zhou et al.   PHYTOTHERAPY RESEARCH

Comparison between the efficacies of curcumin and puerarin in C57BL/6 mice with steatohepatitis induced by a methionine- and choline-deficient diet

(2013) YUNLIANG WANG et al.   Experimental and Therapeutic Medicine

The isoflavone puerarin reduces alcohol intake in heavy drinkers: A pilot study

(2012) David M. Penetar et al.   DRUG AND ALCOHOL DEPENDENCE

Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway

(2012) Y. Zou et al.   FREE RADICAL RESEARCH

Glutathione Is a Key Player in Metal-Induced Oxidative Stress Defenses

(2012) Marijke Jozefczak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice

(2012) GUOCAI LI et al.   Experimental and Therapeutic Medicine

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Restoration of autophagy by puerarin in ethanol-treated hepatocytes via the activation of AMP-activated protein kinase

(2011) Byung-Kyu Noh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduction of body weight, liver steatosis and expression of stearoyl-CoA desaturase 1 by the isoflavone daidzein in diet-induced obesity

(2011) A Crespillo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective role of puerarin on lead-induced alterations of the hepatic glutathione antioxidant system and hyperlipidemia in rats

(2011) Chan-Min Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Effect of Soyasaponins-Rich Extract from Soybean on Acute Alcohol-Induced Hepatotoxicity in Mice

(2011) Xiushi Yang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

(2011) Ka H. Wong et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective Effect of Puerarin on Acute Alcoholic Liver Injury

(2010) Min Zhao et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Nonalcoholic Fatty Liver Disease: Pathology and Pathogenesis

(2010) Dina G. Tiniakos et al.   Annual Review of Pathology-Mechanisms of Disease

Puerarin protects the rat liver against oxidative stress-mediated DNA damage and apoptosis induced by lead

(2010) Chan-Min Liu et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Daidzein supplementation prevents non-alcoholic fatty liver disease through alternation of hepatic gene expression profiles and adipocyte metabolism

(2010) M-H Kim et al.   INTERNATIONAL JOURNAL OF OBESITY

Reduction of leptin secretion by soy isoflavonoids in murine adipocytes in vitro

(2010) Toshio Niwa et al.   Phytochemistry Letters

Therapeutic Effect of Puerarin on Non-Alcoholic Rat Fatty Liver by Improving Leptin Signal Transduction through JAK2/STAT3 Pathways

(2009) Peiyong Zheng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatoprotective effects of daidzein against 7,12-dimetylbenz[α]anthracene-induced oxidative stress in mice

(2009) Choi   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: Similar metabolic profiles in liver and intestine of rats

(2009) Cheng-Feng Luo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Effects of Puerariae radix extract on the increasing intestinal permeability in rat with alcohol-induced liver injury

(2009) Rongrong Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Pathogenesis of non-alcoholic fatty liver disease

(2009) J. K. Dowman et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Soybean Bioactive Components and their Implications to Health—A Review

(2008) Joel Isanga et al.   FOOD REVIEWS INTERNATIONAL

Isoflavone daidzein possesses no antioxidant activities in cell-free assays but induces the antioxidant enzyme catalase

(2008) Andreas Kampkötter et al.   NUTRITION RESEARCH