期刊
FOOD SCIENCE & NUTRITION
卷 10, 期 1, 页码 272-285出版社
WILEY
DOI: 10.1002/fsn3.2668
关键词
liver diseases; natural products; pueraria lobata; puerarin
资金
- Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System
Natural active components from Pueraria lobata can protect the liver and have therapeutic potential for different types of liver diseases through various mechanisms.
In recent years, with the improvement of people's living standard and the change of diet structure, liver disease and its related complications have become a significant public health problem globally. Pueraria lobata (Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep) belongs to the genus Pueraria, which is widely planted and used as medicine and food in Asia with a long history. A variety of natural active products, including puerarin, daidzein, formononetin, genistein, and soyasaponin, have been isolated and identified from pueraria lobata. A large number of studies have shown that various natural active products of pueraria lobata can play a protective role in different types of liver diseases by regulating oxidative stress, inflammatory response, lipid metabolism, etc. In this review, we focused on the protective effects of isoflavones and triterpenoid saponins from pueraria lobata on the liver through different targeted therapeutic mechanisms. What's more, we summarized their therapeutic potential for different types of liver diseases to provide evidence for their clinical application.
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