Cell-Penetrating Peptides: Emerging Tools for mRNA Delivery

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

Development of a novel PTD-mediated IVT-mRNA Delivery Platform for potential Clinical Application as a Protein Therapy approach for Metabolic/Genetic disorders

(2021) Androulla N. Miliotou et al.   Molecular Therapy-Nucleic Acids

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Delivery of synthetic mRNAs for tissue regeneration

(2021) Heidrun Steinle et al.   ADVANCED DRUG DELIVERY REVIEWS

Advances in mRNA non-viral delivery approaches

(2021) Maria L. Ibba et al.   ADVANCED DRUG DELIVERY REVIEWS

mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients

(2021) Maryam Bidram et al.   Vaccines

De Novo Design of Cell‐penetrating Foldamers

(2020) Hidetomo Yokoo et al.   CHEMICAL RECORD

Cell-Penetrating Peptides in Diagnosis and Treatment of Human Diseases: From Preclinical Research to Clinical Application

(2020) Jing Xie et al.   Frontiers in Pharmacology

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Nanomedicine-Based Approaches for mRNA Delivery

(2020) Satoshi Uchida et al.   MOLECULAR PHARMACEUTICS

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

(2019) Asha Kumari Patel et al.   ADVANCED MATERIALS

Design concepts of polyplex micelles for in vivo therapeutic delivery of plasmid DNA and messenger RNA

(2019) Satoshi Uchida et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Secondary structures and cell-penetrating abilities of arginine-rich peptide foldamers

(2019) Makoto Oba et al.   Scientific Reports

Recent Developments in mRNA-Based Protein Supplementation Therapy to Target Lung Diseases

(2019) Itishri Sahu et al.   MOLECULAR THERAPY

Induced packaging of mRNA into polyplex micelles by regulated hybridization with a small number of cholesteryl RNA oligonucleotides directed enhanced in vivo transfection

(2019) Naoto Yoshinaga et al.   BIOMATERIALS

Peptide-mediated delivery of therapeutic mRNA in ovarian cancer

(2019) Dirk van den Brand et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Establishment of an Evaluation Method for Gene Silencing by Serial Pulmonary Administration of siRNA and pDNA Powders: Naked siRNA Inhalation Powder Suppresses Luciferase Gene Expression in the Lung

(2019) Takaaki Ito et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Plasmid DNA Delivery Using Cell-Penetrating Peptide Foldamers Composed of Arg–Arg–Aib Repeating Sequences

(2019) Makoto Oba et al.   ACS Biomaterials-Science & Engineering

Peptide-conjugate antisense based splice-correction for Duchenne muscular dystrophy and other neuromuscular diseases

(2019) Maria K. Tsoumpra et al.   EBioMedicine

Recent CPP-based applications in medicine

(2019) Kaido Kurrikoff et al.   Expert Opinion on Drug Delivery

Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine

(2019) Naho Tateshita et al.   JOURNAL OF CONTROLLED RELEASE

Effective mRNA pulmonary delivery by dry powder formulation of PEGylated synthetic KL4 peptide

(2019) Yingshan Qiu et al.   JOURNAL OF CONTROLLED RELEASE

Kinetic Resolution of Ansa Cyclophanes by Peptide-Catalyzed Aldol/Retro-Aldol Reactions

(2018) Kengo Akagawa et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis

(2018) Ema Robinson et al.   MOLECULAR THERAPY

Cell-penetrating Peptide-modified Targeted Drug-loaded Phase-transformation Lipid Nanoparticles Combined with Low-intensity Focused Ultrasound for Precision Theranostics against Hepatocellular Carcinoma

(2018) Hongyun Zhao et al.   Theranostics

Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics

(2018) Lipeng Gao et al.   Theranostics

mRNA polyplexes with post-conjugated GALA peptides efficiently target, transfect and activate antigen presenting cells

(2018) Bo Lou et al.   BIOCONJUGATE CHEMISTRY

1988–2018: Thirty years of drug smuggling at the nano scale. Challenges and opportunities of cell-penetrating peptides in biomedical research

(2018) Maria Gallo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dom34 mediates targeting of exogenous RNA in the antiviral OAS/RNase L pathway

(2018) Takuto Nogimori et al.   NUCLEIC ACIDS RESEARCH

Poly(lactic acid) nanoparticles and cell-penetrating peptide potentiate mRNA-based vaccine expression in dendritic cells triggering their activation

(2018) Anne-Line Coolen et al.   BIOMATERIALS

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: Restoring the immunogenicity of immunosilent mRNA

(2017) Rein Verbeke et al.   JOURNAL OF CONTROLLED RELEASE

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide

(2017) Vimal K. Udhayakumar et al.   Advanced Healthcare Materials

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

(2017) Ding An et al.   Cell Reports

Specific and Efficient Uptake of Surfactant-Free Poly(Lactic Acid) Nanovaccine Vehicles by Mucosal Dendritic Cells in Adult Zebrafish after Bath Immersion

(2017) Julien Rességuier et al.   Frontiers in Immunology

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Peptides for nucleic acid delivery

(2016) Taavi Lehto et al.   ADVANCED DRUG DELIVERY REVIEWS

Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety

(2016) Satoshi Uchida et al.   BIOMATERIALS

Plasmid DNA delivery by arginine-rich cell-penetrating peptides containing unnatural amino acids

(2016) Takuma Kato et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Dynamic foldamer chemistry

(2016) Bryden A. F. Le Bailly et al.   CHEMICAL COMMUNICATIONS

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Delivery of therapeutic oligonucleotides with cell penetrating peptides

(2015) Prisca Boisguérin et al.   ADVANCED DRUG DELIVERY REVIEWS

Helical screw-sense preferences of peptides based on chiral, Cα-tetrasubstituted α-amino acids

(2015) Marco Crisma et al.   BIOPOLYMERS

Dry Powder Formulation of Plasmid DNA and siRNA for Inhalation

(2015) Michael Chow et al.   CURRENT PHARMACEUTICAL DESIGN

A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides

(2015) Yosuke Demizu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cell-penetrating peptides transport therapeutics into cells

(2015) Joshua D. Ramsey et al.   PHARMACOLOGY & THERAPEUTICS

Nebulisation of IVT mRNA Complexes for Intrapulmonary Administration

(2015) Sarah M. Johler et al.   PLoS One

Mechanism Matters: A Taxonomy of Cell Penetrating Peptides

(2015) W. Berkeley Kauffman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cell-Penetrating Peptides: Design, Synthesis, and Applications

(2014) Dana Maria Copolovici et al.   ACS Nano

Advantages of ethanol dilution method for preparing GALA-modified liposomal siRNA carriers on the in vivo gene knockdown efficiency in pulmonary endothelium

(2014) Kenji Kusumoto et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses

(2014) Núria Climent et al.   VACCINE

Bioinspired Self-Assembled Peptide Nanofibers with Thermostable Multivalent α-Helices

(2013) So-hee Han et al.   BIOMACROMOLECULES

Cell-penetrating peptides: 20 years later, where do we stand?

(2013) Chérine Bechara et al.   FEBS LETTERS

Modified Foxp3 mRNA protects against asthma through an IL-10–dependent mechanism

(2013) Lauren E. Mays et al.   JOURNAL OF CLINICAL INVESTIGATION

Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties

(2013) Vincent Pavot et al.   JOURNAL OF CONTROLLED RELEASE

Peptide Vectors for the Nonviral Delivery of Nucleic Acids

(2012) Jan Hoyer et al.   ACCOUNTS OF CHEMICAL RESEARCH

De Novo Design of Bioactive Protein-Resembling Nanospheres via Dendrimer-Templated Peptide Amphiphile Assembly

(2011) Brian F. Lin et al.   NANO LETTERS

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

(2011) B. R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Biodegradable nanoparticles are excellent vehicle for site directed in-vivo delivery of drugs and vaccines

(2011) Anil Mahapatro et al.   JOURNAL OF NANOBIOTECHNOLOGY

Traffic of poly(lactic acid) nanoparticulate vaccine vehicle from intestinal mucus to sub-epithelial immune competent cells

(2010) Charlotte Primard et al.   BIOMATERIALS

Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation☆

(2010) Hidetaka Akita et al.   JOURNAL OF CONTROLLED RELEASE

mRNA as gene therapeutic: How to control protein expression

(2010) Geertrui Tavernier et al.   JOURNAL OF CONTROLLED RELEASE

Design and Evaluation of Histidine-Rich Amphipathic Peptides for siRNA Delivery

(2010) Bérangère Langlet-Bertin et al.   PHARMACEUTICAL RESEARCH

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

(2009) Patrick Midoux et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo

(2009) Hiroto Hatakeyama et al.   JOURNAL OF CONTROLLED RELEASE

Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides

(2007) Ikuhiko Nakase et al.   ADVANCED DRUG DELIVERY REVIEWS