Selecting instruments for Mendelian randomization in the wake of genome-wide association studies

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis

(2016) Jon White et al.   Lancet Diabetes & Endocrinology

Re: “Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects”

(2015) Stephen Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Multivariable Mendelian Randomization: The Use of Pleiotropic Genetic Variants to Estimate Causal Effects

(2015) S. Burgess et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials

(2015) Daniel I Swerdlow et al.   LANCET

Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis

(2014) Michael V. Holmes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA2)-V Isoenzyme in Coronary Heart Disease: Modified Mendelian Randomization Analysis Using PLA2G5 Expression Levels

(2014) M. V. Holmes et al.   Circulation-Cardiovascular Genetics

Mendelian randomization of blood lipids for coronary heart disease

(2014) Michael V. Holmes et al.   EUROPEAN HEART JOURNAL

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

High tobacco consumption is causally associated with increased all-cause mortality in a general population sample of 55 568 individuals, but not with short telomeres: a Mendelian randomization study

(2014) Line Rode et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Using Multivariable Mendelian Randomization to Disentangle the Causal Effects of Lipid Fractions

(2014) Stephen Burgess et al.   PLoS One

Introduction to causal diagrams for confounder selection

(2014) Elizabeth J. Williamson et al.   RESPIROLOGY

Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data

(2014) M. V. Holmes et al.   BMJ-British Medical Journal

Bayesian Test for Colocalisation between Pairs of Genetic Association Studies Using Summary Statistics

(2014) Claudia Giambartolomei et al.   PLoS Genetics

Efficient Design for Mendelian Randomization Studies: Subsample and 2-Sample Instrumental Variable Estimators

(2013) B. L. Pierce et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14 015 stroke cases and pooled analysis of primary biomarker data from up to 60 883 individuals

(2013) Tauseef A Khan et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Use of allele scores as instrumental variables for Mendelian randomization

(2013) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Secretory Phospholipase A 2 -IIA and Cardiovascular Disease

(2013) Michael V. Holmes et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Lipoprotein Subclass Profiling Reveals Pleiotropy in the Genetic Variants of Lipid Risk Factors for Coronary Heart Disease

(2013) Peter Würtz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Validating therapeutic targets through human genetics

(2013) Robert M. Plenge et al.   NATURE REVIEWS DRUG DISCOVERY

Mining the Human Phenome Using Allelic Scores That Index Biological Intermediates

(2013) David M. Evans et al.   PLoS Genetics

Two-step epigenetic Mendelian randomization: a strategy for establishing the causal role of epigenetic processes in pathways to disease

(2012) Caroline L Relton et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease

(2012) Brian A. Ference et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

The Metabochip, a Custom Genotyping Array for Genetic Studies of Metabolic, Cardiovascular, and Anthropometric Traits

(2012) Benjamin F. Voight et al.   PLoS Genetics

Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster

(2011) Josef Frank et al.   ADDICTION BIOLOGY

Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels

(2011) Abbas Dehghan et al.   CIRCULATION

Avoiding bias from weak instruments in Mendelian randomization studies

(2011) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Pervasive roles of microRNAs in cardiovascular biology

(2011) Eric M. Small et al.   NATURE

Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants

(2011) J.-H. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using multiple genetic variants as instrumental variables for modifiable risk factors

(2011) Tom M Palmer et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Correlation between endothelial function and carotid atherosclerosis in rheumatoid arthritis patients with long-standing disease

(2011) Carlos González-Juanatey et al.   ARTHRITIS RESEARCH & THERAPY

Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR) and 15q24 (CYP1A2) As Determinants of Habitual Caffeine Consumption

(2011) Marilyn C. Cornelis et al.   PLoS Genetics

Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

(2010) Dawn M. Waterworth et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Association of a Fasting Glucose Genetic Risk Score With Subclinical Atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study

(2010) L. J. Rasmussen-Torvik et al.   DIABETES

SNP Selection in genome-wide and candidate gene studies via penalized logistic regression

(2010) Kristin L. Ayers et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults

(2010) Leslie A. Lange et al.   HUMAN MOLECULAR GENETICS

Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants

(2010) Brandon L Pierce et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

(2010) Samuli Ripatti et al.   LANCET

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies

(2010)   LANCET

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

(2010) Elizabeth K Speliotes et al.   NATURE GENETICS

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

(2010) Richa Saxena et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

(2010) Jason Z Liu et al.   NATURE GENETICS

Safety of Anacetrapib in Patients with or at High Risk for Coronary Heart Disease

(2010) Christopher P. Cannon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genome-Wide Association Study of Anthropometric Traits and Evidence of Interactions With Age and Study Year in Filipino Women

(2010) Damien C. Croteau-Chonka et al.   Obesity

Genome-Wide Association Study of Height and Body Mass Index in Australian Twin Families

(2010) Jimmy Z. Liu et al.   Twin Research and Human Genetics

Genome-Wide Association Study of Lp-PLA2 Activity and Mass in the Framingham Heart Study

(2010) Sunil Suchindran et al.   PLoS Genetics

Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS

(2010) Dan L. Nicolae et al.   PLoS Genetics

Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth

(2010) Cathy E. Elks et al.   PLOS MEDICINE

Relation of Age-related Cataract With Obesity and Obesity Genes in an Asian Population

(2009) L. S. Lim et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Apolipoprotein E Genotype, Plasma Cholesterol, and Cancer: A Mendelian Randomization Study

(2009) S. Trompet et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Separating the Mechanism-Based and Off-Target Actions of Cholesteryl Ester Transfer Protein Inhibitors With CETP Gene Polymorphisms

(2009) Reecha Sofat et al.   CIRCULATION

Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction

(2009) Paul M. Ridker et al.   Circulation-Cardiovascular Genetics

Hepatic nuclear factor 1-α: inflammation, genetics, and atherosclerosis

(2009) Angela D Armendariz et al.   CURRENT OPINION IN LIPIDOLOGY

Circulating β-carotene levels and type 2 diabetes—cause or effect?

(2009) J. R. B. Perry et al.   DIABETOLOGIA

Genome-wide Association Studies and Human Disease

(2009) Peter M. Visscher et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease

(2009) Paul Elliott   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q

(2009) Carole Ober et al.   JOURNAL OF LIPID RESEARCH

New susceptibility locus for coronary artery disease on chromosome 3q22.3

(2009) Jeanette Erdmann et al.   NATURE GENETICS

Genome-wide association study identifies eight loci associated with blood pressure

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Genome-wide association study of blood pressure and hypertension

(2009) Daniel Levy et al.   NATURE GENETICS

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

(2009) Robert Clarke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Linkage and Genome-wide Association Analysis of Obesity-related Phenotypes: Association of Weight With the MGAT1 Gene

(2009) Åsa Johansson et al.   Obesity

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations

(2009) Melanie Kolz et al.   PLoS Genetics

Bayesian Meta-Analysis of Genetic Association Studies with Different Sets of Markers

(2008) Claudio Verzilli et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study

(2008) Paul M. Ridker et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome-wide Association Study Identifies Genes for Biomarkers of Cardiovascular Disease: Serum Urate and Dyslipidemia

(2008) Chris Wallace et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap

(2008) A. D. Johnson et al.   BIOINFORMATICS

Collaborative pooled analysis of data on C-reactive protein gene variants and coronary disease: judging causality by Mendelian randomisation

(2008)   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Serum cholesterol, apolipoprotein E genotype and depressive symptoms in elderly European men: The FINE study

(2008) Erik J. Giltay et al.   JOURNAL OF AFFECTIVE DISORDERS

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

(2008) Chiara Sabatti et al.   NATURE GENETICS

Common variants near MC4R are associated with fat mass, weight and risk of obesity

(2008) Ruth J F Loos et al.   NATURE GENETICS

Common variants at 30 loci contribute to polygenic dyslipidemia

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

(2008) Gudmar Thorleifsson et al.   NATURE GENETICS

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

(2008) Cristen J Willer et al.   NATURE GENETICS

Common genetic variation near MC4R is associated with waist circumference and insulin resistance

(2008) John C Chambers et al.   NATURE GENETICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

(2008) Cristen J Willer et al.   NATURE GENETICS

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Genome-wide association studies for complex traits: consensus, uncertainty and challenges

(2008) Mark I. McCarthy et al.   NATURE REVIEWS GENETICS

Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein

(2008) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study

(2008) Patrick Linsel-Nitschke et al.   PLoS One

Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

(2008) Brendan J. Keating et al.   PLoS One

Whole-genome association study identifies STK39 as a hypertension susceptibility gene

(2008) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology

(2007) Debbie A. Lawlor et al.   STATISTICS IN MEDICINE