Porphyromonas gingivalis Induces Proinflammatory Cytokine Expression Leading to Apoptotic Death through the Oxidative Stress/NF-κB Pathway in Brain Endothelial Cells

Adiponectin protects obesity-related glomerulopathy by inhibiting ROS/NF-κB/NLRP3 inflammation pathway

(2021) Xiaohong Xu et al.   BMC Nephrology

Polyphyllin VI Induces Caspase-1-Mediated Pyroptosis via the Induction of ROS/NF-κB/NLRP3/GSDMD Signal Axis in Non-Small Cell Lung Cancer

(2020) Jin-Feng Teng et al.   Cancers

Alzheimer’s Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains

(2020) Ursula Haditsch et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial cathepsin B and Porphyromonas gingivalis gingipains as potential therapeutic targets for sporadic Alzheimer’s disease

(2020) Hiroshi Nakanishi et al.   CNS & Neurological Disorders-Drug Targets

Did the Brain and Oral Microbiota Talk to Each Other? A Review of the Literature

(2020) Yoann Maitre et al.   Journal of Clinical Medicine

Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

(2019) Stephen S. Dominy et al.   Science Advances

Assessing the role of Porphyromonas gingivalis in periodontitis to determine a causative relationship with Alzheimer’s disease

(2019) Sim K. Singhrao et al.   Journal of Oral Microbiology

IVIVC Assessment of Two Mouse Brain Endothelial Cell Models for Drug Screening

(2019) Ina Puscas et al.   Pharmaceutics

Isolation of endothelial cells, pericytes and astrocytes from mouse brain

(2019) Florian Bernard-Patrzynski et al.   PLoS One

Redox Signaling, Neuroinflammation, and Neurodegeneration

(2018) Gabriela Aguilera et al.   ANTIOXIDANTS & REDOX SIGNALING

Redox Signaling in Neurotransmission and Cognition During Aging

(2018) Ashok Kumar et al.   ANTIOXIDANTS & REDOX SIGNALING

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Chronic Oral Infection: An Emerging Risk Factor of Cerebral Small Vessel Disease?

(2018) Ghazal Aarabi et al.   ORAL DISEASES

Porphyromonas gingivalis, a periodontitis causing bacterium, induces memory impairment and age-dependent neuroinflammation in mice

(2018) Ye Ding et al.   Immunity & Ageing

Implications of Systemic Inflammation and Periodontitis for Major Depression

(2018) Sadayuki Hashioka et al.   Frontiers in Neuroscience

Porphyromonas gingivalis -induced inflammatory responses in THP1 cells are altered by native and modified low-density lipoproteins in a strain-dependent manner

(2018) Kartheyaene Jayaprakash et al.   APMIS

Hyperglycemia modulates redox, inflammatory and vasoactive markers through specific signaling pathways in cerebral endothelial cells: Insights on insulin protective action

(2018) Angélique Arcambal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide

(2018) Dawei Lian et al.   MOLECULAR IMMUNOLOGY

Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis

(2017) Marc-André Lécuyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Periodontal diseases

(2017) Denis F. Kinane et al.   Nature Reviews Disease Primers

Osteoblast Apoptosis in Periodontal Disease: Role of TNF-Related Apoptosis-Inducing Ligand

(2017) G. Mori et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The Role of Anti-Cyclic Citrullinated Peptide Antibody in Periodontal Disease

(2017) A. Ballini et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Staphylococcus aureus-mediated blood-brain barrier injury: anin vitrohuman brain microvascular endothelial cell model

(2016) Alisha McLoughlin et al.   CELLULAR MICROBIOLOGY

Activation of classical estrogen receptor subtypes reduces tight junction disruption of brain endothelial cells under ischemia/reperfusion injury

(2016) Jin A. Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lumbrokinase attenuates myocardial ischemia-reperfusion injury by inhibiting TLR4 signaling

(2016) Yi-Hsin Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line

(2016) Kah Yan How et al.   Frontiers in Microbiology

Periodontitis and Cognitive Decline in Alzheimer’s Disease

(2016) Mark Ide et al.   PLoS One

Effects of Paeonol on Anti-Neuroinflammatory Responses in Microglial Cells

(2015) Chingju Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

P. gingivalis in Periodontal Disease and Atherosclerosis – Scenes of Action for Antimicrobial Peptides and Complement

(2015) Mehak Hussain et al.   Frontiers in Immunology

Porphyromonas gingivalis-Induced Reactive Oxygen Species Activate JAK2 and Regulate Production of Inflammatory Cytokines through c-Jun

(2014) Huizhi Wang et al.   INFECTION AND IMMUNITY

Hispolon inhibition of inflammatory apoptosis through reduction of iNOS/NO production via HO-1 induction in macrophages

(2014) Liang-Yo Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Regulatory Effects of Fisetin on Microglial Activation

(2014) Jing-Yuan Chuang et al.   MOLECULES

Periodontitis-activated monocytes/macrophages cause aortic inflammation

(2014) Shin-ichi Miyajima et al.   Scientific Reports

N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities

(2014) Reza Bavarsad Shahripour et al.   Brain and Behavior

Hypoxia-inducible factor 1 contributes to N-acetylcysteine’s protection in stroke

(2013) Ziyan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study

(2013) Frederick Palm et al.   Innate Immunity

Environmental Stimuli Shape Biofilm Formation and the Virulence of Periodontal Pathogens

(2013) Marja Pöllänen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exposure to Inflammatory Cytokines IL-1β and TNFα Induces Compromise and Death of Astrocytes; Implications for Chronic Neuroinflammation

(2013) Christa van Kralingen et al.   PLoS One

Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss

(2013) H. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interaction of inflammatory and anti-inflammatory responses in microglia by Staphylococcus aureus-derived lipoteichoic acid

(2013) Bor-Ren Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer’s disease

(2013) B Parajuli et al.   Cell Death & Disease

Ceramide and Toll-Like Receptor 4 Are Mobilized into Membrane Rafts in Response to Helicobacter pylori Infection in Gastric Epithelial Cells

(2012) Dah-Yuu Lu et al.   INFECTION AND IMMUNITY

Wogonin Induces Reactive Oxygen Species Production and Cell Apoptosis in Human Glioma Cancer Cells

(2012) Cheng-Fang Tsai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased levels of Porphyromonas gingivalis are associated with ischemic and hemorrhagic cerebrovascular disease in humans: an in vivo study

(2012) Janaina Salomon Ghizoni et al.   Journal of Applied Oral Science

Regulation of inducible heme oxygenase and cyclooxygenase isozymes in a mouse model of spotted fever group rickettsiosis

(2012) Elena Rydkina et al.   MICROBIAL PATHOGENESIS

The global burden of periodontal disease: towards integration with chronic disease prevention and control

(2012) Poul E. Petersen et al.   PERIODONTOLOGY 2000

The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways

(2012) Dah-Yuu Lu et al.   PHYTOMEDICINE

Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis

(2011) Pedro Bullon et al.   FREE RADICAL BIOLOGY AND MEDICINE

Helicobacter pylori attenuates lipopolysaccharide-induced nitric oxide production by murine macrophages

(2011) Dah-Yuu Lu et al.   Innate Immunity

Mitochondrial reactive oxygen species drive proinflammatory cytokine production: Figure 1.

(2011) Edwina Naik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Crosstalk of reactive oxygen species and NF-κB signaling

(2010) Michael J Morgan et al.   CELL RESEARCH

Peptidoglycan enhances proinflammatory cytokine expression through the TLR2 receptor, MyD88, phosphatidylinositol 3-kinase/AKT and NF-kappaB pathways in BV-2 microglia

(2010) Hsiao-Yun Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

“Gum Bug, Leave My Heart Alone!”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

(2010) M. Kebschull et al.   JOURNAL OF DENTAL RESEARCH

Experimental Models for Assaying Microvascular Endothelial Cell Pathophysiology in Stroke

(2010) Susanna Camós et al.   MOLECULES

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Porphyromonas gingivalis induce apoptosis in human gingival epithelial cells through a gingipain-dependent mechanism

(2009) Panagiota G Stathopoulou et al.   BMC MICROBIOLOGY

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Hypoxia-induced matrix metalloproteinase-13 expression in astrocytes enhances permeability of brain endothelial cells

(2009) Dah-Yuu Lu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Clathrin-dependent entry of a gingipain adhesin peptide andPorphyromonas gingivalisinto host cells

(2008) Heike Boisvert et al.   CELLULAR MICROBIOLOGY

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY