Single-Cell Transcriptomics Reveals the Expression of Aging- and Senescence-Associated Genes in Distinct Cancer Cell Populations

Nebulosa recovers single-cell gene expression signals by kernel density estimation

(2021) Jose Alquicira-Hernandez et al.   BIOINFORMATICS

Epigenetics of Aging and Aging-Associated Diseases

(2021) Dominik Saul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Decreased HLF Expression Predicts Poor Survival in Lung Adenocarcinoma

(2021) Zaiyan Wang et al.   MEDICAL SCIENCE MONITOR

Senolytics for Cancer Therapy: Is All that Glitters Really Gold?

(2021) Valerie J. Carpenter et al.   Cancers

A signature of 24 aging‑related gene pairs predict overall survival in gastric cancer

(2021) Yankai Zhang et al.   Biomedical Engineering Online

Comprehensive analysis of a chemokine- and chemokine receptor family-based signature for patients with lung adenocarcinoma

(2021) Tao Fan et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

HNRNPA2B1 promotes multiple myeloma progression by increasing AKT3 expression via m6A-dependent stabilization of ILF3 mRNA

(2021) Fengjie Jiang et al.   Journal of Hematology & Oncology

SOCS2 is a potential prognostic marker that suppresses the viability of hepatocellular carcinoma cells

(2021) Jiankun Liu et al.   Oncology Letters

Mouse aging cell atlas analysis reveals global and cell type-specific aging signatures

(2021) Martin Jinye Zhang et al.   eLife

Preoperative immune landscape predisposes adverse outcomes in hepatocellular carcinoma patients with liver transplantation

(2021) Sang-Ho Yoon et al.   npj Precision Oncology

Downregulation of RPS14 inhibits the proliferation and metastasis of estrogen receptor-positive breast cancer cells

(2021) Xiu Wang et al.   ANTI-CANCER DRUGS

Tumor cells in light-chain amyloidosis and myeloma show different transcriptional rewiring of normal plasma cell development

(2021) Daniel Alameda et al.   BLOOD

The ever‐increasing importance of cancer as a leading cause of premature death worldwide

(2021) Freddie Bray et al.   CANCER

Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma

(2021) Lichun Ma et al.   JOURNAL OF HEPATOLOGY

The Cancer SENESCopedia: A delineation of cancer cell senescence

(2021) Fleur Jochems et al.   Cell Reports

Lifespan-Associated Gene Expression Signatures of Recombinant BXD Mice Implicates Coro7 and Set in Longevity

(2021) David Vitiello et al.   Frontiers in Genetics

Identification of Aging-Related Genes Associated With Clinical and Prognostic Features of Hepatocellular Carcinoma

(2021) Xingte Chen et al.   Frontiers in Genetics

Identification and Validation of Hub Genes Associated With Hepatocellular Carcinoma Via Integrated Bioinformatics Analysis

(2021) Sumei Wang et al.   Frontiers in Oncology

Modulation of fracture healing by the transient accumulation of senescent cells

(2021) Dominik Saul et al.   eLife

Comparative peptidome profiling reveals critical roles for peptides in the pathology of pancreatic cancer

(2020) Xingxing Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Annual report to the nation on the status of cancer, part I: National cancer statistics

(2020) S. Jane Henley et al.   CANCER

Carcinogenesis of Pancreatic Ductal Adenocarcinoma

(2020) Peter Storz et al.   GASTROENTEROLOGY

Germline CDKN1B Loss-of-Function Variants Cause Pediatric Cushing’s Disease With or Without an MEN4 Phenotype

(2020) Fanny Chasseloup et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer

(2020) Hae-Ock Lee et al.   NATURE GENETICS

PPARG Drives Molecular Networks as an Inhibitor for the Pathologic Development and Progression of Lung Adenocarcinoma

(2020) Min Zhao et al.   PPAR Research

Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma

(2020) Nayoung Kim et al.   Nature Communications

Comprehensive analysis of the SLC16A gene family in pancreatic cancer via integrated bioinformatics

(2020) Shan Yu et al.   Scientific Reports

Cells of origin of lung cancers: lessons from mouse studies

(2020) Giustina Ferone et al.   GENES & DEVELOPMENT

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Ageing hallmarks exhibit organ-specific temporal signatures

(2020) Nicholas Schaum et al.   NATURE

Prostate cancer reactivates developmental epigenomic programs during metastatic progression

(2020) Mark M. Pomerantz et al.   NATURE GENETICS

Transcriptome profiling reveals the high incidence of hnRNPA1 exon 8 inclusion in chronic myeloid leukemia

(2020) Shu-Qi Li et al.   Journal of Advanced Research

SLC16 Family: From Atomic Structure to Human Disease

(2020) Patrick D. Bosshart et al.   TRENDS IN BIOCHEMICAL SCIENCES

Master Regulator Activating Transcription Factor 3 (ATF3) in Metabolic Homeostasis and Cancer

(2020) Hui-Chen Ku et al.   Frontiers in Endocrinology

Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation

(2020) Frederick Guzman et al.   Cancers

Immune-Related Gene Expression and Cytokine Secretion Is Reduced Among African American Colon Cancer Patients

(2020) Jenny Paredes et al.   Frontiers in Oncology

Identifying longevity associated genes by integrating gene expression and curated annotations

(2020) F. William Townes et al.   PLoS Computational Biology

Widespread Aberrant Alternative Splicing despite Molecular Remission in Chronic Myeloid Leukaemia Patients

(2020) Ulf Schmitz et al.   Cancers

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The hyper-activation of transcriptional enhancers in breast cancer

(2019) Qing-Lan Li et al.   Clinical Epigenetics

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

(2019) Junya Peng et al.   CELL RESEARCH

Transcriptome signature of cellular senescence

(2019) Gabriel Casella et al.   NUCLEIC ACIDS RESEARCH

Current cancer situation in China: good or bad news from the 2018 Global Cancer Statistics?

(2019) Rui-Mei Feng et al.   Cancer Communications

Comprehensive analysis of transcriptome profiles in hepatocellular carcinoma

(2019) Yu Jin et al.   Journal of Translational Medicine

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts

(2019) Yosuke Mitsui et al.   ONCOLOGY RESEARCH

The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy

(2019) Kreis et al.   Cancers

A prognostic index based on an eleven gene signature to predict systemic recurrences in colorectal cancer

(2019) Seon-Kyu Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Aging-Induced Biological Changes and Cardiovascular Diseases

(2018) James Oluwagbamigbe Fajemiroye et al.   Biomed Research International

Cellular senescence: Molecular mechanisms and pathogenicity

(2018) Wenqiang Wei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Polycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms

(2018) Ho Lam Chan et al.   Nature Communications

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity

(2018) Giovanna Butera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Network-based integration of mRNA and miRNA profiles reveals new target genes involved in pancreatic cancer

(2018) Jie Lin et al.   MOLECULAR CARCINOGENESIS

Visualizing and Interpreting Single-Cell Gene Expression Datasets with Similarity Weighted Nonnegative Embedding

(2018) Yan Wu et al.   Cell Systems

Targeting cellular senescence prevents age-related bone loss in mice

(2017) Joshua N Farr et al.   NATURE MEDICINE

Reversed graph embedding resolves complex single-cell trajectories

(2017) Xiaojie Qiu et al.   NATURE METHODS

Tumour heterogeneity and resistance to cancer therapies

(2017) Ibiayi Dagogo-Jack et al.   Nature Reviews Clinical Oncology

Human Ageing Genomic Resources: new and updated databases

(2017) Robi Tacutu et al.   NUCLEIC ACIDS RESEARCH

S100A11 promotes human pancreatic cancer PANC‑1 cell proliferation and is involved in the PI3K/AKT signaling pathway

(2017) Mingbing Xiao et al.   Oncology Letters

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

(2017) Krishna S. Tummala et al.   Cell Reports

The Dual Role of Cellular Senescence in Developing Tumors and Their Response to Cancer Therapy

(2017) Markus Schosserer et al.   Frontiers in Oncology

Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting

(2016) Xiu-yan Huang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements

(2016) Tatyana G. Kahn et al.   NUCLEIC ACIDS RESEARCH

Complex Behavior of ALDH1A1 and IGFBP1 in Liver Metastasis from a Colorectal Cancer

(2016) Jin Cheon Kim et al.   PLoS One

Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics

(2016) Toshihiro Yoneyama et al.   PLoS One

Next-generation sequencing reveals novel differentially regulated mRNAs, lncRNAs, miRNAs, sdRNAs and a piRNA in pancreatic cancer

(2015) Sören Müller et al.   Molecular Cancer

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Modulation of PKM alternative splicing by PTBP1 promotes gemcitabine resistance in pancreatic cancer cells

(2015) S Calabretta et al.   ONCOGENE

Exploiting tumor cell senescence in anticancer therapy

(2014) Minyoung Lee et al.   BMB Reports

Geroscience: Linking Aging to Chronic Disease

(2014) Brian K. Kennedy et al.   CELL

Gene expression profiling of replicative and induced senescence

(2014) Maggie Purcell et al.   CELL CYCLE

A nineteen gene-based risk score classifier predicts prognosis of colorectal cancer patients

(2014) Seon-Kyu Kim et al.   Molecular Oncology

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

(2014) Alex K. Shalek et al.   NATURE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

MiR-19a/b modulate the metastasis of gastric cancer cells by targeting the tumour suppressor MXD1

(2014) Q Wu et al.   Cell Death & Disease

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Ribosomal Protein S14 Negatively Regulates c-Myc Activity

(2013) Xiang Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic Instability and Colon Carcinogenesis: From the Perspective of Genes

(2013) Chinthalapally V. Rao et al.   Frontiers in Oncology

Novel insight into the role of GAPDH playing in tumor

(2012) Chunmei Guo et al.   Clinical & Translational Oncology

The transcriptional landscape and mutational profile of lung adenocarcinoma

(2012) J.-S. Seo et al.   GENOME RESEARCH

Expression of the Aldo-Ketoreductases AKR1B1 and AKR1B10 in Human Cancers

(2012) Brian Laffin et al.   Frontiers in Pharmacology

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

(2009) João Pedro de Magalhães et al.   BIOINFORMATICS

Aurora kinase A is a target of Wnt/ -catenin involved in multiple myeloma disease progression

(2009) J. Dutta-Simmons et al.   BLOOD

MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma

(2009) A. M. Roccaro et al.   BLOOD

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE