The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression

SIRT3 consolidates heterochromatin and counteracts senescence

(2021) Zhiqing Diao et al.   NUCLEIC ACIDS RESEARCH

Adult neurogenic process in the subventricular zone‐olfactory bulb system is regulated by Tau protein under prolonged stress

(2021) Chrysoula Dioli et al.   CELL PROLIFERATION

Neural stem cells in the adult olfactory bulb core generate mature neurons in vivo

(2021) Çağla Defteralı et al.   STEM CELLS

Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life

(2020) Gabriel Berdugo-Vega et al.   Nature Communications

Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer’s Disease

(2020) Thomas Berger et al.   TRENDS IN MOLECULAR MEDICINE

Association between olfactory function and inhibition of emotional competing distractors in major depressive disorder

(2020) Fang Wang et al.   Scientific Reports

Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation

(2020) Marta B. Fernandes et al.   Frontiers in Cell and Developmental Biology

Diet, Stress and Mental Health

(2020) J. Douglas Bremner et al.   Nutrients

Risk of Dementia in persons who have previously experienced clinically-significant Depression, Anxiety, or PTSD: A Systematic Review and Meta-Analysis

(2020) J.K. Kuring et al.   JOURNAL OF AFFECTIVE DISORDERS

Sirt3 Attenuates Oxidative Stress Damage and Rescues Cellular Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Superoxide Dismutase 2

(2020) Cao Ma et al.   Frontiers in Cell and Developmental Biology

Rejuvenating subventricular zone neurogenesis in the aging brain

(2019) Ronald R Cutler et al.   CURRENT OPINION IN PHARMACOLOGY

Human Neural Stem Cells Reinforce Hippocampal Synaptic Network and Rescue Cognitive Deficits in a Mouse Model of Alzheimer's Disease

(2019) Ting Zhang et al.   Stem Cell Reports

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States

(2018) Mark P. Mattson et al.   Cell Metabolism

Human Adult Neurogenesis: Evidence and Remaining Questions

(2018) Gerd Kempermann et al.   Cell Stem Cell

Mitochondria and the dynamic control of stem cell homeostasis

(2018) Pawel Lisowski et al.   EMBO REPORTS

Intermittent metabolic switching, neuroplasticity and brain health

(2018) Mark P. Mattson et al.   NATURE REVIEWS NEUROSCIENCE

Mitochondria as central regulators of neural stem cell fate and cognitive function

(2018) Mireille Khacho et al.   NATURE REVIEWS NEUROSCIENCE

Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats

(2017) Rita Soares et al.   MOLECULAR NEUROBIOLOGY

Behavioral changes in male mice fed a high-fat diet are associated with IL-1β expression in specific brain regions

(2017) Camila P. Almeida-Suhett et al.   PHYSIOLOGY & BEHAVIOR

The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence

(2017) Giuliana S. Zuccoli et al.   Frontiers in Neuroscience

Redox control of senescence and age-related disease

(2017) Akshaya Chandrasekaran et al.   Redox Biology

Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease

(2016) Aneesa Ansari et al.   AGING CELL

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

(2016) Aiwu Cheng et al.   Cell Metabolism

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Depression with melancholic features is associated with higher long-term risk for dementia

(2016) Frederico Simões do Couto et al.   JOURNAL OF AFFECTIVE DISORDERS

Anxiety- and Depression-Like States Lead to Pronounced Olfactory Deficits and Impaired Adult Neurogenesis in Mice

(2016) E. Siopi et al.   JOURNAL OF NEUROSCIENCE

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Chronic oxidative stress upregulates Drusen-related protein expression in adult human RPE stem cell-derived RPE cells: A novel culture model for dry AMD

(2016) David M. Rabin et al.   Aging-US

Classic and novel stem cell niches in brain homeostasis and repair

(2015) Ruihe Lin et al.   BRAIN RESEARCH

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

Mitochondria

(2015) Joana M. Xavier et al.   NEUROSCIENTIST

Connecting Mitochondria, Metabolism, and Stem Cell Fate

(2015) Anaïs Wanet et al.   STEM CELLS AND DEVELOPMENT

Skeletal Muscle PGC-1α1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression

(2014) Leandro Z. Agudelo et al.   CELL

Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling

(2014) Joana M Xavier et al.   CELL CYCLE

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

(2014) Ozkan Ozden et al.   FREE RADICAL BIOLOGY AND MEDICINE

Adult Neurogenesis and Mental Illness

(2014) Timothy J Schoenfeld et al.   NEUROPSYCHOPHARMACOLOGY

Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder

(2014) Gaurav Patki et al.   PHYSIOLOGY & BEHAVIOR

Novel mechanistic insights into treadmill exercise based rescue of social defeat-induced anxiety-like behavior and memory impairment in rats

(2014) Gaurav Patki et al.   PHYSIOLOGY & BEHAVIOR

Mitochondrial Translocation of p53 Modulates Neuronal Fate by Preventing Differentiation-Induced Mitochondrial Stress

(2013) Joana M. Xavier et al.   ANTIOXIDANTS & REDOX SIGNALING

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging

(2012) Albert Giralt et al.   BIOCHEMICAL JOURNAL

SIRT3 regulation of mitochondrial oxidative stress

(2012) Alexandra S. Bause et al.   EXPERIMENTAL GERONTOLOGY

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

Aging Neural Progenitor Cells Have Decreased Mitochondrial Content and Lower Oxidative Metabolism

(2011) Elizabeth A. Stoll et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress

(2010) R J Schloesser et al.   MOLECULAR PSYCHIATRY

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Murine Features of Neurogenesis in the Human Hippocampus across the Lifespan from 0 to 100 Years

(2010) Rolf Knoth et al.   PLoS One

Adult neural stem cells in the mammalian central nervous system

(2009) Dengke K Ma et al.   CELL RESEARCH

An optimized experimental strategy for efficient conversion of embryonic stem (ES)-derived mouse neural stem (NS) cells into a nearly homogeneous mature neuronal population

(2009) D. Spiliotopoulos et al.   NEUROBIOLOGY OF DISEASE

The effect of aging on the response of isolated hepatocytes to hydrogen peroxide and tert-butyl hydroperoxide

(2009) Tharani Sabaretnam et al.   TOXICOLOGY IN VITRO

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL