Cell Cycle, Telomeres, and Telomerase in Leishmania spp.: What Do We Know So Far?

Exploring TERRA during Leishmania major developmental cycle and continuous in vitro passages

(2021) Edna Gicela Ortiz Morea et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Diverse telomeres in trypanosomatids

(2021) Ester Poláková et al.   PARASITOLOGY

The Maze Pathway of Coevolution: A Critical Review over the Leishmania and Its Endosymbiotic History

(2021) Lilian Motta Cantanhêde et al.   Genes

Leishmaniasis: the act of transmission

(2021) Tiago D. Serafim et al.   TRENDS IN PARASITOLOGY

Possible Involvement of Hsp90 in the Regulation of Telomere Length and Telomerase Activity During the Leishmania amazonensis Developmental Cycle and Population Proliferation

(2021) Beatriz C. D. de Oliveira et al.   Frontiers in Cell and Developmental Biology

Universal highly efficient conditional knockout system in Leishmania , with a focus on untranscribed region preservation

(2020) Akila Yagoubat et al.   CELLULAR MICROBIOLOGY

Potential Telomere-Related Pharmacological Targets

(2020) Joseph Berei et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Comparative Analysis of the Minimum Number of Replication Origins in Trypanosomatids and Yeasts

(2020) Marcelo S. da Silva et al.   Genes

A multi-approach analysis highlights the relevance of RPA-1 as a telomere end-binding protein (TEBP) in Leishmania amazonensis

(2020) Carlos A.H. Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Gene Editing in Trypanosomatids: Tips and Tricks in the CRISPR-Cas9 Era

(2020) Akila Yagoubat et al.   TRENDS IN PARASITOLOGY

Telomerase Biogenesis and Activities from the Perspective of Its Direct Interacting Partners

(2020) Kathryn T. T. T. Nguyen et al.   Cancers

CRISPR-based engineering of gene knockout cells by homology-directed insertion in polyploid Drosophila S2R+ cells

(2020) Baolong Xia et al.   Nature Protocols

Alternate histories of cytokinesis: lessons from the trypanosomatids

(2020) Paul C. Campbell et al.   MOLECULAR BIOLOGY OF THE CELL

Telomere Biology and Human Phenotype

(2019) Kara Turner et al.   Cells

Roles of Telomere Biology in Cell Senescence, Replicative and Chronological Ageing

(2019) Jun Liu et al.   Cells

Telomeres and telomerase: three decades of progress

(2019) Jerry W. Shay et al.   NATURE REVIEWS GENETICS

Dual cellular localization of the Leishmania amazonensis Rbp38 (LaRbp38) explains its affinity for telomeric and mitochondrial DNA

(2019) Carlos A.H. Fernandes et al.   BIOCHIMIE

TPP1 OB-fold domain protein suppresses cell proliferation and induces cell apoptosis by inhibiting telomerase recruitment to telomeres in human lung cancer cells

(2019) Jinfang Zhu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

State‐of‐the‐art CRISPR /Cas9 Technology for Genome Editing in Trypanosomatids

(2019) Noelia Lander et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Genome and transcriptome analyses of Leishmania spp.: opening Pandora’s box

(2019) Angela Kaysel Cruz et al.   CURRENT OPINION IN MICROBIOLOGY

Transcription activity contributes to the firing of non-constitutive origins in African trypanosomes helping to maintain robustness in S-phase duration

(2019) Marcelo S. da Silva et al.   Scientific Reports

Chaperones And Their Role In Telomerase Ribonucleoprotein Biogenesis And Telomere Maintenance

(2018) Maria Isabel Nogueira Cano et al.   Current Proteomics

Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Leishmaniasis

(2018) Sakib Burza et al.   LANCET

Nucleolar Division in the Promastigote Stage of Leishmania major Parasite: A Nop56 Point of View

(2018) Tomás Nepomuceno-Mejía et al.   Biomed Research International

Differences in the Detection of BrdU/EdU Incorporation Assays Alter the Calculation for G1, S, and G2 Phases of the Cell Cycle in Trypanosomatids

(2017) Marcelo Santos da Silva et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Evidence for regulated expression of Telomeric Repeat-containing RNAs (TERRA) in parasitic trypanosomatids

(2017) Jeziel D Damasceno et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Nuclear DNA Replication in Trypanosomatids: There Are No Easy Methods for Solving Difficult Problems

(2017) Marcelo S. da Silva et al.   TRENDS IN PARASITOLOGY

Leishmaniasis in humans: drug or vaccine therapy?

(2017) Masoud Ghorbani et al.   Drug Design Development and Therapy

Small molecule inhibitor screening identifified HSP90 inhibitor 17-AAG as potential therapeutic agent for gallbladder cancer

(2017) Helga Weber et al.   Oncotarget

Regulating telomere length from the inside out: the replication fork model

(2016) Carol W. Greider   GENES & DEVELOPMENT

Flagellar pocket restructuring through theLeishmanialife cycle involves a discrete flagellum attachment zone

(2016) Richard J. Wheeler et al.   JOURNAL OF CELL SCIENCE

The cell fate: senescence or quiescence

(2016) Menderes Yusuf Terzi et al.   MOLECULAR BIOLOGY REPORTS

Evolutionary perspectives of telomerase RNA structure and function

(2016) Joshua D. Podlevsky et al.   RNA Biology

Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis

(2015) Hugo O. Valdivia et al.   BMC GENOMICS

The Centriole Cartwheel Protein SAS-6 in Trypanosoma brucei Is Required for Probasal Body Biogenesis and Flagellum Assembly

(2015) Huiqing Hu et al.   EUKARYOTIC CELL

Human telomerase: biogenesis, trafficking, recruitment, and activation

(2015) Jens C. Schmidt et al.   GENES & DEVELOPMENT

Structural basis of template-boundary definition in Tetrahymena telomerase

(2015) Linnea I Jansson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions

(2015) J. Jiang et al.   SCIENCE

Structural basis of template-boundary definition in Tetrahymena telomerase

(2015) Linnea I Jansson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomerase reverse transcriptase in the regulation of gene expression

(2014) Junzhi Zhou et al.   BMB Reports

Telomerase structure

(2014) Sara Sandin et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

RPA-1 fromLeishmania amazonensis(LaRPA-1) structurally differs from other eukaryote RPA-1 and interacts with telomeric DNA via its N-terminal OB-fold domain

(2014) R.S. Pavani et al.   FEBS LETTERS

Leishmania major Telomerase TERT Protein Has a Nuclear/Mitochondrial Eclipsed Distribution That Is Affected by Oxidative Stress

(2014) Riward Campelo et al.   INFECTION AND IMMUNITY

Structural basis for protein-RNA recognition in telomerase

(2014) Jing Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Putative Leishmania Telomerase RNA (LeishTER) Undergoes Trans-Splicing and Contains a Conserved Template Sequence

(2014) Elton J. R. Vasconcelos et al.   PLoS One

The Normalcy of Dormancy: Common Themes in Microbial Quiescence

(2013) Emily S.C. Rittershaus et al.   Cell Host & Microbe

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei

(2013) Ranjodh Sandhu et al.   CELL RESEARCH

TheTrypanosoma bruceitelomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family

(2013) Sachin Kumar Gupta et al.   FEBS LETTERS

Leishmania amazonensis Promastigotes Present Two Distinct Modes of Nucleus and Kinetoplast Segregation during Cell Cycle

(2013) Marcelo Santos da Silva et al.   PLoS One

The Limits on Trypanosomatid Morphological Diversity

(2013) Richard John Wheeler et al.   PLoS One

Cell cycle control across the eukaryotic kingdom

(2013) Hirofumi Harashima et al.   TRENDS IN CELL BIOLOGY

Biogenesis of telomerase ribonucleoproteins

(2012) E. D. Egan et al.   RNA

Telomere-independent functions of telomerase in nuclei, cytoplasm, and mitochondria

(2012) Ilaria Chiodi et al.   Frontiers in Oncology

Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA

(2011) Yan Xu   CHEMICAL SOCIETY REVIEWS

Single-stranded DNA repeat synthesis by telomerase

(2011) Kathleen Collins   CURRENT OPINION IN CHEMICAL BIOLOGY

Morphological Events during the Cell Cycle of Leishmania major

(2011) Audrey Ambit et al.   EUKARYOTIC CELL

Kinetoplast Morphology and Segregation Pattern as a Marker for Cell Cycle Progression in Leishmania donovani1

(2011) NEHA MINOCHA et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Human Telomerase Domain Interactions Capture DNA for TEN Domain-Dependent Processive Elongation

(2011) Aaron R. Robart et al.   MOLECULAR CELL

The Cell Cycle Regulated Transcriptome of Trypanosoma brucei

(2011) Stuart K. Archer et al.   PLoS One

The Leishmania amazonensis TRF (TTAGGG repeat binding factor) homologue binds and co-localizes with telomeres

(2010) Marcelo S da Silva et al.   BMC MICROBIOLOGY

POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation

(2010) Chrysa M Latrick et al.   EMBO JOURNAL

Leishmania amazonensis: Partial purification and study of the biochemical properties of the telomerase reverse transcriptase activity from promastigote-stage

(2010) M.A. Giardini et al.   EXPERIMENTAL PARASITOLOGY

The cell cycle of Leishmania: morphogenetic events and their implications for parasite biology

(2010) Richard J. Wheeler et al.   MOLECULAR MICROBIOLOGY

Base J: Discovery, Biosynthesis, and Possible Functions

(2008) Piet Borst et al.   Annual Review of Microbiology

PlasmodiumTelomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds

(2008) Anne De Cian et al.   CHEMBIOCHEM

Trypanosoma brucei Spliced Leader RNA Maturation by the Cap 1 2'-O-Ribose Methyltransferase and SLA1 H/ACA snoRNA Pseudouridine Synthase Complex

(2008) J. R. Zamudio et al.   MOLECULAR AND CELLULAR BIOLOGY

TERT promotes cellular and organismal survival independently of telomerase activity

(2008) J Lee et al.   ONCOGENE