Current Perspectives of Telomerase Structure and Function in Eukaryotes with Emerging Views on Telomerase in Human Parasites

Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Bone Marrow Failure Syndromes

(2017) Hunter Hoffman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYC drives overexpression of telomerase RNA (hTR /TERC ) in prostate cancer

(2017) Javier A Baena-Del Valle et al.   JOURNAL OF PATHOLOGY

Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer

(2017) Cong Chen et al.   Nature Communications

Tying up the Ends: Plasticity in the Recognition of Single-Stranded DNA at Telomeres

(2016) Neil R. Lloyd et al.   BIOCHEMISTRY

Reactivation of telomerase in cancer

(2016) Semih Can Akincilar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structure and folding of theTetrahymenatelomerase RNA pseudoknot

(2016) Darian D. Cash et al.   NUCLEIC ACIDS RESEARCH

The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes

(2016) Joshua D. Podlevsky et al.   NUCLEIC ACIDS RESEARCH

Multi-step coordination of telomerase recruitment in fission yeast through two coupled telomere-telomerase interfaces

(2016) Xichan Hu et al.   eLife

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

(2015) Ali Salanti et al.   CANCER CELL

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

(2015) Dong-Sheng Huang et al.   EUROPEAN JOURNAL OF CANCER

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomerase RNA stem terminus element affects template boundary element function, telomere sequence, and shelterin binding

(2015) Christopher J. Webb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells

(2015) Chung-Ping Hsu et al.   TUMOR BIOLOGY

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cancer-associated TERT promoter mutations abrogate telomerase silencing

(2015) Kunitoshi Chiba et al.   eLife

A loopy view of telomere evolution

(2015) Titia de Lange   Frontiers in Genetics

Mobile DNA elements in the generation of diversity and complexity in the brain

(2014) Jennifer A. Erwin et al.   NATURE REVIEWS NEUROSCIENCE

Structural basis for protein-RNA recognition in telomerase

(2014) Jing Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase

(2014) Varuni K. Jamburuthugoda et al.   NUCLEIC ACIDS RESEARCH

Mechanism by which a LINE protein recognizes its 3′ tail RNA

(2014) Yoshinori Hayashi et al.   NUCLEIC ACIDS RESEARCH

The Putative Leishmania Telomerase RNA (LeishTER) Undergoes Trans-Splicing and Contains a Conserved Template Sequence

(2014) Elton J. R. Vasconcelos et al.   PLoS One

P. berghei Telomerase Subunit TERT is Essential for Parasite Survival

(2014) Agnieszka A. Religa et al.   PLoS One

A self-regulating template in human telomerase

(2014) A. F. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A trans-spliced telomerase RNA dictates telomere synthesis in Trypanosoma brucei

(2013) Ranjodh Sandhu et al.   CELL RESEARCH

TERT promoter mutations in cancer development

(2013) Barbara Heidenreich et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

TheTrypanosoma bruceitelomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family

(2013) Sachin Kumar Gupta et al.   FEBS LETTERS

A Conserved Motif inTetrahymena thermophilaTelomerase Reverse Transcriptase Is Proximal to the RNA Template and Is Essential for Boundary Definition

(2013) Benjamin M. Akiyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrimidine motif triple helix in the Kluyveromyces lactis telomerase RNA pseudoknot is essential for function in vivo

(2013) D. D. Cash et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

Mutually Exclusive Binding of Telomerase RNA and DNA by Ku Alters Telomerase Recruitment Model

(2012) Jennifer S. Pfingsten et al.   CELL

An Enhanced H/ACA RNP Assembly Mechanism for Human Telomerase RNA

(2012) E. D. Egan et al.   MOLECULAR AND CELLULAR BIOLOGY

Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65

(2012) Mahavir Singh et al.   MOLECULAR CELL

Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes

(2012) Wen Tang et al.   NATURE

Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway

(2012) Jean-François Noël et al.   NUCLEIC ACIDS RESEARCH

The common ancestral core of vertebrate and fungal telomerase RNAs

(2012) Xiaodong Qi et al.   NUCLEIC ACIDS RESEARCH

Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution

(2012) Karen A. Lewis et al.   STRUCTURE

Telomere Length Affects the Frequency and Mechanism of Antigenic Variation in Trypanosoma brucei

(2012) Galadriel A. Hovel-Miner et al.   PLoS Pathogens

Single-stranded DNA repeat synthesis by telomerase

(2011) Kathleen Collins   CURRENT OPINION IN CHEMICAL BIOLOGY

RNA/DNA hybrid binding affinity determines telomerase template-translocation efficiency

(2011) Xiaodong Qi et al.   EMBO JOURNAL

Disruption of telomerase trafficking by TCAB1 mutation causes dyskeratosis congenita

(2011) F. Zhong et al.   GENES & DEVELOPMENT

The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in Tetrahymena

(2011) Benjamin R. Linger et al.   MOLECULAR BIOLOGY OF THE CELL

Human Telomerase Domain Interactions Capture DNA for TEN Domain-Dependent Processive Elongation

(2011) Aaron R. Robart et al.   MOLECULAR CELL

Telomerase regulation

(2011) Catherine Cifuentes-Rojas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation

(2011) Jason A. Stewart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Unravelling the means to an end: RNA polymerase II transcription termination

(2011) Jason N. Kuehner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis

(2011) Andrea J Berman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Telomerase and retrotransposons: Reverse transcriptases that shaped genomes

(2011) M. Belfort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNA-protein binding interface in the telomerase ribonucleoprotein

(2011) C. J. Bley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of human telomerase RNA

(2011) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing

(2011) N. Jamonnak et al.   RNA

Dyskeratosis Congenita

(2011) I. Dokal   Hematology-American Society of Hematology Education Program

TPP1 Is Required for TERT Recruitment, Telomere Elongation during Nuclear Reprogramming, and Normal Skin Development in Mice

(2010) Agueda M. Tejera et al.   DEVELOPMENTAL CELL

Functional interaction between telomere protein TPP1 and telomerase

(2010) A. J. Zaug et al.   GENES & DEVELOPMENT

Multiple Mechanisms for Elongation Processivity within the ReconstitutedTetrahymenaTelomerase Holoenzyme

(2010) Bosun Min et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The 5' Guanosine Tracts of Human Telomerase RNA Are Recognized by the G-Quadruplex Binding Domain of the RNA Helicase DHX36 and Function To Increase RNA Accumulation

(2010) A. N. Sexton et al.   MOLECULAR AND CELLULAR BIOLOGY

TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo

(2010) E. Abreu et al.   MOLECULAR AND CELLULAR BIOLOGY

Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants

(2010) A. J. Berman et al.   MOLECULAR AND CELLULAR BIOLOGY

The Terminal Telomeric DNA Sequence Determines the Mechanism of Dysfunctional Telomere Fusion

(2010) Bradley A. Stohr et al.   MOLECULAR CELL

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

(2010) Meghan Mitchell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reduced Rif2 and lack of Mec1 target short telomeres for elongation rather than double-strand break repair

(2010) Jean S McGee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structurally conserved five nucleotide bulge determines the overall topology of the core domain of human telomerase RNA

(2010) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomerase: An RNP Enzyme Synthesizes DNA

(2010) E. H. Blackburn et al.   Cold Spring Harbor Perspectives in Biology

Syndromes of Telomere Shortening

(2009) Mary Armanios   Annual Review of Genomics and Human Genetics

Protection and replication of telomeres in fission yeastThis paper is one of a selection of papers published in this Special Issue, entitled 30th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal’s usual peer review process.

(2009) Bettina A. Moser et al.   Biochemistry and Cell Biology

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

RAP1 Is Essential for Silencing Telomeric Variant Surface Glycoprotein Genes in Trypanosoma brucei

(2009) Xiaofeng Yang et al.   CELL

An RPA-Related Sequence-Specific DNA-Binding Subunit of Telomerase Holoenzyme Is Required for Elongation Processivity and Telomere Maintenance

(2009) Bosun Min et al.   MOLECULAR CELL

Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements

(2009) S. Gunisova et al.   RNA

A Human Telomerase Holoenzyme Protein Required for Cajal Body Localization and Telomere Synthesis

(2009) A. S. Venteicher et al.   SCIENCE

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

TINF2, a Component of the Shelterin Telomere Protection Complex, Is Mutated in Dyskeratosis Congenita

(2008) Sharon A. Savage et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres

(2008) Franck Gallardo et al.   EMBO JOURNAL

The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery

(2008) Séverine Boulon et al.   JOURNAL OF CELL BIOLOGY

Dyskerin Is a Component of the Arabidopsis Telomerase RNP Required for Telomere Maintenance

(2008) K. Kannan et al.   MOLECULAR AND CELLULAR BIOLOGY

Spliceosomal cleavage generates the 3′ end of telomerase RNA

(2008) Jessica A. Box et al.   NATURE

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

(2008) Andrew J. Gillis et al.   NATURE

Triple-helix structure in telomerase RNA contributes to catalysis

(2008) Feng Qiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutations in the telomerase component NHP2 cause the premature ageing syndrome dyskeratosis congenita

(2008) T. Vulliamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine leukemia virus reverse transcriptase: Structural comparison with HIV-1 reverse transcriptase

(2008) Marie L. Coté et al.   VIRUS RESEARCH

Physiological assembly and activity of human telomerase complexes

(2007) Kathleen Collins   MECHANISMS OF AGEING AND DEVELOPMENT

Telomere uncapping and alternative lengthening of telomeres

(2007) Anthony J. Cesare et al.   MECHANISMS OF AGEING AND DEVELOPMENT