Journal
TRENDS IN PARASITOLOGY
Volume 33, Issue 11, Pages 858-874Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.pt.2017.08.002
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Funding
- Sao Paulo Research Foundation (FAPESP) Center of Toxins, Immune Response and Cell Signaling (CeTICS) [2014/24170-5, 2013/07467-1, 2015/10580-0, 2016/50050-2]
- National Council for Scientific and Technological Development (CNPq) [304329/2015-0]
- TriTrypDB
- timetree.org
- Wellcome Trust [089172, 083485, 104111, 105614]
- BBSRC [BB/K006495/1, BB/N016165/1]
- RCUK-CONFAP [BB/M028909/1]
- Fundacao para a Glenda e Tecnologia [SFRH/BD/68784/2010]
- European Commission [RECREPEMLE]
- BBSRC [BB/M028909/1, BB/N016165/1, BB/K006495/1] Funding Source: UKRI
- MRC [G0401553] Funding Source: UKRI
- Fundação para a Ciência e a Tecnologia [SFRH/BD/68784/2010] Funding Source: FCT
- Biotechnology and Biological Sciences Research Council [BB/M028909/1, BB/K006495/1, BB/N016165/1] Funding Source: researchfish
- Medical Research Council [G0401553] Funding Source: researchfish
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In trypanosomatids, etiological agents of devastating diseases, replication is robust and finely controlled to maintain genome stability and function in stressful environments. However, these parasites encode several replication protein components and complexes that show potentially variant composition compared with model eukaryotes. This review focuses on the advances made in recent years regarding the differences and peculiarities of the replication machinery in trypanosomatids, including how such divergence might affect DNA replication dynamics and the replication stress response. Comparing the DNA replication machinery and processes of parasites and their hosts may provide a foundation for the identification of targets that can be used in the development of chemotherapies to assist in the eradication of diseases caused by these pathogens.
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