Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis

MicroRNAs: Their Role in Metastasis, Angiogenesis, and the Potential for Biomarker Utility in Bladder Carcinomas

(2021) Raneem Y. Hammouz et al.   Cancers

Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity

(2021) Rui Zhang et al.   SEMINARS IN CANCER BIOLOGY

Vimentin Intermediate Filaments as Potential Target for Cancer Treatment

(2020) Katerina Strouhalova et al.   Cancers

A flexible network of vimentin intermediate filaments promotes migration of amoeboid cancer cells through confined environments

(2020) Sandrine B. Lavenus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vimentin prevents a miR-dependent negative regulation of tissue factor mRNA during epithelial–mesenchymal transitions and facilitates early metastasis

(2020) Marie-Emilie Francart et al.   ONCOGENE

EMT Factors and Metabolic Pathways in Cancer

(2020) Ilias Georgakopoulos-Soares et al.   Frontiers in Oncology

MicroRNA-17-5p regulates EMT by targeting vimentin in colorectal cancer

(2020) Tae Won Kim et al.   BRITISH JOURNAL OF CANCER

Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

(2020) Nora Feldker et al.   EMBO JOURNAL

Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections

(2020) Irene Ramos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Vascular effect of levonorgestrel intrauterine system on heavy menstrual bleeding: is it associated with hemodynamic changes in uterine, radial, and spiral arteries?

(2020) Hanifi Şahin et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

EMT, MET, Plasticity, and Tumor Metastasis

(2020) Basil Bakir et al.   TRENDS IN CELL BIOLOGY

Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies

(2020) Lia Walcher et al.   Frontiers in Immunology

A Novel Long Non-Coding RNA-01488 Suppressed Metastasis and Tumorigenesis by Inducing miRNAs That Reduce Vimentin Expression and Ubiquitination of Cyclin E

(2020) Syuan-Ling Lin et al.   Cells

Cancer Stem Cell Plasticity – A Deadly Deal

(2020) Archana P. Thankamony et al.   Frontiers in Molecular Biosciences

1735P SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models

(2020) C.A. Stewart et al.   ANNALS OF ONCOLOGY

Mechanical and Non‐Mechanical Functions of Filamentous and Non‐Filamentous Vimentin

(2020) Alison E. Patteson et al.   BIOESSAYS

Plasticity of cancer cell invasion: Patterns and mechanisms

(2020) Jia-shun Wu et al.   Translational Oncology

The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes

(2020) Ralf Hass et al.   Cancers

Epigenetic Mechanisms Influencing Epithelial to Mesenchymal Transition in Bladder Cancer

(2019) Sara Monteiro-Reis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ZEB1 promotes tumorigenesis and metastasis in hepatocellular carcinoma by regulating the expression of vimentin

(2019) Yue Qin et al.   Molecular Medicine Reports

Cancer Cells Invade Confined Microchannels via a Self-Directed Mesenchymal-to-Amoeboid Transition

(2019) Andrew W. Holle et al.   NANO LETTERS

MicroRNA-1275 inhibits cell migration and invasion in gastric cancer by regulating vimentin and E-cadherin via JAZF1

(2019) Jia-Wei Mei et al.   BMC CANCER

Vimentin activation in early apoptotic cancer cells errands survival pathways during DNA damage inducer CPT treatment in colon carcinoma model

(2019) Souneek Chakraborty et al.   Cell Death & Disease

Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis

(2019) Longxiang Su et al.   Scientific Reports

The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges

(2019) Loh et al.   Cells

Keratin intermediate filaments: intermediaries of epithelial cell migration

(2019) Sungjun Yoon et al.   Essays in Biochemistry

Vimentin protects cells against nuclear rupture and DNA damage during migration

(2019) Alison E. Patteson et al.   JOURNAL OF CELL BIOLOGY

AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications

(2019) Chenjing Zhu et al.   Molecular Cancer

Mechanisms of 3D cell migration

(2019) Kenneth M. Yamada et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vimentin filaments interact with the actin cortex in mitosis allowing normal cell division

(2019) Sofia Duarte et al.   Nature Communications

Diversity and functional evolution of the plasminogen activator system

(2018) Rishi Kumar Jaiswal et al.   BIOMEDICINE & PHARMACOTHERAPY

Twist1 regulates Vimentin through Cul2 circular RNA to promote EMT in hepatocellular carcinoma

(2018) Jing Meng et al.   CANCER RESEARCH

LncRNA FTX sponges miR-215 and inhibits phosphorylation of vimentin for promoting colorectal cancer progression

(2018) Yi Yang et al.   GENE THERAPY

Sex determining region Y-box 2 is a prognostic factor for head and neck squamous cell carcinoma: Evidence from 11 published investigations

(2018) Bo Li et al.   Journal of Cancer Research and Therapeutics

Upregulation of the EMT marker vimentin is associated with poor clinical outcome in acute myeloid leukemia

(2018) Sharon Wu et al.   Journal of Translational Medicine

TR4 nuclear receptor promotes clear cell renal cell carcinoma (ccRCC) vasculogenic mimicry (VM) formation and metastasis via altering the miR490-3p/vimentin signals

(2018) Jian Bai et al.   ONCOGENE

The Epithelial-to-Mesenchymal Transition in Cancer

(2018) Joëlle Roche   Cancers

MiR-876-5p modulates head and neck squamous cell carcinoma metastasis and invasion by targeting vimentin

(2018) Yibo Dong et al.   Cancer Cell International

Histone deacetylase 6 in cancer

(2018) Ting Li et al.   Journal of Hematology & Oncology

Hybrid epithelial/mesenchymal phenotypes promote metastasis and therapy resistance across carcinomas

(2018) Mohit Kumar Jolly et al.   PHARMACOLOGY & THERAPEUTICS

Vimentin Diversity in Health and Disease

(2018) Frida Danielsson et al.   Cells

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition

(2018) Nicolas Skrypek et al.   Epigenetics & Chromatin

The roles of ZEB1 in tumorigenic progression and epigenetic modifications

(2018) Yu Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

miR-373 suppresses gastric cancer metastasis by downregulating vimentin

(2017) Yinghong Shi et al.   Molecular Medicine Reports

EMT and MET: necessary or permissive for metastasis?

(2017) Mohit Kumar Jolly et al.   Molecular Oncology

EMT and inflammation: inseparable actors of cancer progression

(2017) Meggy Suarez-Carmona et al.   Molecular Oncology

Myc mediates cancer stem-like cells and EMT changes in triple negative breast cancers cells

(2017) Shuping Yin et al.   PLoS One

Amoeboid-mesenchymal migration plasticity promotes invasion only in complex heterogeneous microenvironments

(2017) Katrin Talkenberger et al.   Scientific Reports

Integrin β4 promotes cell invasion and epithelial-mesenchymal transition through the modulation of Slug expression in hepatocellular carcinoma

(2017) Xiao-Long Li et al.   Scientific Reports

Breast Carcinoma: From Initial Tumor Cell Detachment to Settlement at Secondary Sites

(2017) Catharina Melzer et al.   Biomed Research International

The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation

(2017) Chang Dong Yeo et al.   KOREAN JOURNAL OF INTERNAL MEDICINE

Vimentin regulates differentiation switch via modulation of keratin 14 levels and their expression together correlates with poor prognosis in oral cancer patients

(2017) Crismita Dmello et al.   PLoS One

miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer

(2017) Hidekazu Hiramoto et al.   Scientific Reports

Urokinase-type plasminogen activator receptor (uPAR) expression enhances invasion and metastasis in RAS mutated tumors

(2017) Concetta Di Mauro et al.   Scientific Reports

The hypoxic microenvironment: A determinant of cancer stem cell evolution

(2016) Amancio Carnero et al.   BIOESSAYS

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

H2AX and EMT: deciphering beyond DNA repair

(2016) Urbain Weyemi et al.   CELL CYCLE

Impact of Expression of Vimentin and Axl in Breast Cancer

(2016) Kimihiro Tanaka et al.   Clinical Breast Cancer

Vimentin filament controls integrin α5β1-mediated cell adhesion by binding to integrin through its Ser38 residue

(2016) Jiyoon Kim et al.   FEBS LETTERS

MiR-548an, Transcriptionally Downregulated by HIF1 /HDAC1, Suppresses Tumorigenesis of Pancreatic Cancer by Targeting Vimentin Expression

(2016) S. Zhu et al.   MOLECULAR CANCER THERAPEUTICS

USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells

(2016) Ying Zhu et al.   Oncotarget

Downregulation of vimentin expression increased drug resistance in ovarian cancer cells

(2016) Yi Huo et al.   Oncotarget

Epithelial cell migration requires the interaction between the vimentin and keratin intermediate filaments

(2016) Cristina Velez-delValle et al.   Scientific Reports

The Importance of CD44 as a Stem Cell Biomarker and Therapeutic Target in Cancer

(2016) Ranjeeta Thapa et al.   Stem Cells International

Vimentin Intermediate Filaments Template Microtubule Networks to Enhance Persistence in Cell Polarity and Directed Migration

(2016) Zhuo Gan et al.   Cell Systems

Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway

(2016) Yifan Wang et al.   Scientific Reports

Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function

(2015) Reetta Virtakoivu et al.   CANCER RESEARCH

ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

(2015) Peijing Zhang et al.   CELL CYCLE

Upregulation of integrin β4 promotes epithelial–mesenchymal transition and is a novel prognostic marker in pancreatic ductal adenocarcinoma

(2015) Y Masugi et al.   LABORATORY INVESTIGATION

Involvement of urokinase in cigarette smoke extract-induced epithelial–mesenchymal transition in human small airway epithelial cells

(2015) Qin Wang et al.   LABORATORY INVESTIGATION

Clinical significance of the integrin α6β4 in human malignancies

(2015) Rachel L Stewart et al.   LABORATORY INVESTIGATION

Upregulation of microRNA-138-5p inhibits pancreatic cancer cell migration and increases chemotherapy sensitivity

(2015) CHAO YU et al.   Molecular Medicine Reports

Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma

(2015) Pilar Bayo et al.   Molecular Oncology

Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition

(2015) Tong-Hong Wang et al.   Oncotarget

Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation

(2015) Ching-Yi Liu et al.   Oncotarget

Mesenchymal to amoeboid transition is associated with stem-like features of melanoma cells

(2014) Maria Taddei et al.   Cell Communication and Signaling

The Role of Snail in EMT and Tumorigenesis

(2014) Yifan Wang et al.   CURRENT CANCER DRUG TARGETS

Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis

(2014) Ravshan Burikhanov et al.   Nature Chemical Biology

Molecular mechanisms of epithelial–mesenchymal transition

(2014) Samy Lamouille et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Snail Promotes Epithelial Mesenchymal Transition in Breast Cancer Cells in Part via Activation of Nuclear ERK2

(2014) Bethany N. Smith et al.   PLoS One

Oncogenes induce a vimentin filament collapse mediated by HDAC6 that is linked to cell stiffness

(2014) L.-S. Z. Rathje et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling mechanisms of the epithelial-mesenchymal transition

(2014) D. M. Gonzalez et al.   Science Signaling

Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

(2014) Suling Liu et al.   Stem Cell Reports

Crosstalk of Oncogenic Signaling Pathways during Epithelial–Mesenchymal Transition

(2014) Stephan Lindsey et al.   Frontiers in Oncology

The Role of Vimentin Intermediate Filaments in the Progression of Lung Cancer

(2013) Martha E Kidd et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

(2013) Gregg L. Semenza   Annual Review of Pathology-Mechanisms of Disease

Vimentin phosphorylation and assembly are regulated by the small GTPase Rab7a

(2013) Laura Cogli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Anoikis molecular pathways and its role in cancer progression

(2013) Paolo Paoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

Mature miR-17-5p and passenger miR-17-3p induce hepatocellular carcinoma by targeting PTEN, GalNT7 and vimentin in different signal pathways

(2013) S. W. Shan et al.   JOURNAL OF CELL SCIENCE

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

DNA-PK Target Identification Reveals Novel Links between DNA Repair Signaling and Cytoskeletal Regulation

(2013) Ewa Kotula et al.   PLoS One

Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation

(2012) Hyeong-Il Kwak et al.   ANGIOGENESIS

MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer

(2012) Chun-Wen Cheng et al.   BREAST CANCER RESEARCH AND TREATMENT

Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma

(2012) Aibing Wu et al.   CANCER LETTERS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Hepatitis B virus X protein (HBx)-related long noncoding RNA (lncRNA) down-regulated expression by HBx (Dreh) inhibits hepatocellular carcinoma metastasis by targeting the intermediate filament protein vimentin

(2012) Jin-feng Huang et al.   HEPATOLOGY

Cancer stem cells

(2012) Zuoren Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Intermediate Filament Vimentin Mediates MicroRNA miR-378 Function in Cellular Self-renewal by Regulating the Expression of the Sox2 Transcription Factor

(2012) Zhaoqun Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarkers of Epithelial-Mesenchymal Transition in Squamous Cell Carcinoma

(2012) C.S. Scanlon et al.   JOURNAL OF DENTAL RESEARCH

Hepatitis C Virus Induces Epithelial-Mesenchymal Transition in Primary Human Hepatocytes

(2012) S. K. Bose et al.   JOURNAL OF VIROLOGY

Paracrine and Autocrine Signals Induce and Maintain Mesenchymal and Stem Cell States in the Breast

(2011) Christina Scheel et al.   CELL

Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer

(2011) Nicole Vincent Jordan et al.   CELL CYCLE

Vimentin is sufficient and required for wound repair and remodeling in alveolar epithelial cells

(2011) Micah R. Rogel et al.   FASEB JOURNAL

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells?

(2011) Christina Scheel et al.   INTERNATIONAL JOURNAL OF CANCER

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TGF-β Receptor Inhibitors Target the CD44high/Id1high Glioma-Initiating Cell Population in Human Glioblastoma

(2010) Judit Anido et al.   CANCER CELL

CD24: from A to Z

(2010) Xianfeng Fang et al.   Cellular & Molecular Immunology

Vimentin is a novel AKT1 target mediating motility and invasion

(2010) Q-S Zhu et al.   ONCOGENE

Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer

(2010) K Vuoriluoto et al.   ONCOGENE

Filamin A is required for vimentin-mediated cell adhesion and spreading

(2009) Hugh Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Recurrent copy number gain of transcription factorSOX2and corresponding high protein expression in oral squamous cell carcinoma

(2009) Kolja Freier et al.   GENES CHROMOSOMES & CANCER

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Upregulation of vimentin and aberrant expression of E-cadherin/β-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome

(2009) Lai-Kui Liu et al.   MODERN PATHOLOGY

Vimentin Regulates Scribble Activity by Protecting It from Proteasomal Degradation

(2009) Dominic C.Y. Phua et al.   MOLECULAR BIOLOGY OF THE CELL