Structure of native HIV-1 cores and their interactions with IP6 and CypA

A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly

(2021) Nadine Renner et al.   PLoS Pathogens

A stable immature lattice packages IP6 for HIV capsid maturation

(2021) Donna L. Mallery et al.   Science Advances

A conformational switch in response to Chi converts RecBCD from phage destruction to DNA repair

(2020) Kaiying Cheng et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clinical targeting of HIV capsid protein with a long-acting small molecule

(2020) John O. Link et al.   NATURE

Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

(2020) Tao Ni et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-resolution structure of HIV-1 capsid tubes by magic-angle spinning NMR

(2020) Manman Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-scale characterization of mature HIV-1 capsid stabilization by inositol hexakisphosphate (IP6)

(2020) Alvin Yu et al.   Science Advances

The Host Cell Metabolite Inositol Hexakisphosphate Promotes Efficient Endogenous HIV-1 Reverse Transcription by Stabilizing the Viral Capsid

(2020) Jordan Jennings et al.   mBio

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

(2020) Chaoyi Xu et al.   PLOS BIOLOGY

MxB Restricts HIV-1 by Targeting the Tri-hexamer Interface of the Viral Capsid

(2019) Sarah Sierra Smaga et al.   STRUCTURE

Modular HIV-1 Capsid Assemblies Reveal Diverse Host-Capsid Recognition Mechanisms

(2019) Brady J. Summers et al.   Cell Host & Microbe

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

(2019) Stephen R. Yant et al.   NATURE MEDICINE

Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids

(2019) Katarzyna A. Skorupka et al.   Science Advances

Truncated CPSF6 Forms Higher-Order Complexes That Bind and Disrupt HIV-1 Capsid

(2018) Jiying Ning et al.   JOURNAL OF VIROLOGY

Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis

(2018) Chantal L Márquez et al.   eLife

IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis

(2018) Donna L Mallery et al.   eLife

PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating

(2018) Sanela Rankovic et al.   JOURNAL OF VIROLOGY

Inositol phosphates are assembly co-factors for HIV-1

(2018) Robert A. Dick et al.   NATURE

The Human Immunodeficiency Virus Capsid Is More Than Just a Genome Package

(2018) Leo C. James et al.   Annual Review of Virology

emClarity: software for high-resolution cryo-electron tomography and subtomogram averaging

(2018) Benjamin A. Himes et al.   NATURE METHODS

Thresholding of cryo-EM density maps by false discovery rate control

(2018) Maximilian Beckers et al.   IUCrJ

Automated tilt series alignment and tomographic reconstruction in IMOD

(2017) David N. Mastronarde et al.   JOURNAL OF STRUCTURAL BIOLOGY

Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging

(2017) Wim J.H. Hagen et al.   JOURNAL OF STRUCTURAL BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Physical properties of the HIV-1 capsid from all-atom molecular dynamics simulations

(2017) Juan R. Perilla et al.   Nature Communications

All-Atom Molecular Dynamics of Virus Capsids as Drug Targets

(2016) Juan R. Perilla et al.   Journal of Physical Chemistry Letters

HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis

(2016) David A. Jacques et al.   NATURE

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

(2016) Jing Huang et al.   NATURE METHODS

The structure and flexibility of conical HIV-1 capsids determined within intact virions

(2016) Simone Mattei et al.   SCIENCE

Cyclophilin A stabilizes the HIV-1 capsid through a novel non-canonical binding site

(2016) Chuang Liu et al.   Nature Communications

Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells

(2016) Ashwanth C. Francis et al.   PLoS Pathogens

Crystal structure of an HIV assembly and maturation switch

(2016) Jonathan M Wagner et al.   eLife

HIV-1 capsid: the multifaceted key player in HIV-1 infection

(2015) Edward M. Campbell et al.   NATURE REVIEWS MICROBIOLOGY

GPU-accelerated analysis and visualization of large structures solved by molecular dynamics flexible fitting

(2014) John E. Stone et al.   FARADAY DISCUSSIONS

Volta potential phase plate for in-focus phase contrast transmission electron microscopy

(2014) R. Danev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of HIV-1 capsid recognition by PF74 and CPSF6

(2014) Akash Bhattacharya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generalized scalable multiple copy algorithms for molecular dynamics simulations in NAMD

(2013) Wei Jiang et al.   COMPUTER PHYSICS COMMUNICATIONS

Self-Learning Adaptive Umbrella Sampling Method for the Determination of Free Energy Landscapes in Multiple Dimensions

(2013) Wojciech Wojtas-Niziurski et al.   Journal of Chemical Theory and Computation

Using collective variables to drive molecular dynamics simulations

(2013) Giacomo Fiorin et al.   MOLECULAR PHYSICS

Mature HIV-1 capsid structure by cryo-electron microscopy and all-atom molecular dynamics

(2013) Gongpu Zhao et al.   NATURE

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

(2012) K. Vanommeslaeghe et al.   Journal of Chemical Information and Modeling

Calculation of Free Energy Landscape in Multi-Dimensions with Hamiltonian-Exchange Umbrella Sampling on Petascale Supercomputer

(2012) Wei Jiang et al.   Journal of Chemical Theory and Computation

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Atomic-level modelling of the HIV capsid

(2011) Owen Pornillos et al.   NATURE

Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function

(2009) In-Ja L. Byeon et al.   CELL

Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography

(2009) Leonardo G. Trabuco et al.   METHODS

Three-Dimensional Analysis of Budding Sites and Released Virus Suggests a Revised Model for HIV-1 Morphogenesis

(2008) Lars-Anders Carlson et al.   Cell Host & Microbe

A noncytotoxic DsRed variant for whole-cell labeling

(2008) Rita L Strack et al.   NATURE METHODS