Structural Evolution of TIR-Domain Signalosomes

Mechanics of a molecular mousetrap-- nucleation-limited innate immune signaling

(2021) Alejandro Rodríguez Gama et al.   BIOPHYSICAL JOURNAL

Cryo-EM structures of Toll-like receptors in complex with UNC93B1

(2021) Hanako Ishida et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration

(2021) Matthew D. Figley et al.   NEURON

Structural and functional understanding of the toll‐like receptors

(2021) Jinta Asami et al.   PROTEIN SCIENCE

MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography

(2021) Max T. B. Clabbers et al.   Nature Communications

Toll-Like Receptors: General Molecular and Structural Biology

(2021) Payam Behzadi et al.   Journal of Immunology Research

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate Immunity

(2021) Eleanor L. Hopkins et al.   Frontiers in Molecular Biosciences

Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection

(2021) Yo Sasaki et al.   EXPERIMENTAL NEUROLOGY

Evolution of Plant NLRs: From Natural History to Precise Modifications

(2020) Janina Tamborski et al.   Annual Review of Plant Biology

MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling

(2020) Martin C. Moncrieffe et al.   STRUCTURE

The TIR-domain containing effectors BtpA and BtpB from Brucella abortus impact NAD metabolism

(2020) Julia María Coronas-Serna et al.   PLoS Pathogens

Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation

(2020) Donghyun Ka et al.   Nature Communications

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

(2020) Matthew Bratkowski et al.   Cell Reports

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative Sarm1

(2020) Yuefeng Jiang et al.   NATURE

Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme

(2020) Shoucai Ma et al.   SCIENCE

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

(2020) Raoul Martin et al.   SCIENCE

SARM: From immune regulator to cell executioner

(2019) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

Structural Evidence for an Octameric Ring Arrangement of SARM1

(2019) Michael Sporny et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis of IL-1 Family Cytokine Signaling

(2019) James K. Fields et al.   Frontiers in Immunology

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Systematic discovery of antiphage defense systems in the microbial pangenome

(2018) Shany Doron et al.   SCIENCE

Pathological mutations differentially affect the self-assembly and polymerisation of the innate immune system signalling adaptor molecule MyD88

(2018) Ailís O’Carroll et al.   BMC BIOLOGY

The synaptic and neuronal functions of the X‐linked intellectual disability protein Interleukin‐1 receptor accessory protein like 1 ( IL 1 RAPL 1)

(2018) Caterina Montani et al.   Developmental Neurobiology

Death, TIR, and RHIM: Self-assembling domains involved in innate immunity and cell-death signaling

(2018) Jeffrey D. Nanson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The family of the interleukin-1 receptors

(2017) Diana Boraschi et al.   IMMUNOLOGICAL REVIEWS

The molecular mechanisms of signaling by cooperative assembly formation in innate immunity pathways

(2017) Parimala R. Vajjhala et al.   MOLECULAR IMMUNOLOGY

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Multiple functional self-association interfaces in plant TIR domains

(2017) Xiaoxiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TIR-only protein RBA1 recognizes a pathogen effector to regulate cell death inArabidopsis

(2017) Marc T. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

(2017) Thomas Ve et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome

(2016) Samer Halabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation

(2016) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Function of the TIR Domain from the Grape NLR Protein RPV1

(2016) Simon J. Williams et al.   Frontiers in Plant Science

Structure and function of Toll/interleukin-1 receptor/resistance protein (TIR) domains

(2014) Thomas Ve et al.   APOPTOSIS

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Crystal Structure of TIR Domain of TLR6 Reveals Novel Dimeric Interface of TIR–TIR Interaction for Toll-Like Receptor Signaling Pathway

(2014) Tae-ho Jang et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor

(2014) S. J. Williams et al.   SCIENCE

Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from theBrucellaProtein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

(2013) Greg A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

The interleukin-1 receptor family

(2013) Diana Boraschi et al.   SEMINARS IN IMMUNOLOGY

Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets

(2012) Thomas Ve et al.   CURRENT DRUG TARGETS

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt

(2011) T. D. Troutman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Subversion of Innate Immune Responses by Brucella through the Targeted Degradation of the TLR Signaling Adapter, MAL

(2009) D. Sengupta et al.   JOURNAL OF IMMUNOLOGY

Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis

(2009) Maciej Lech et al.   JOURNAL OF PATHOLOGY

The crystal structure of a TIR domain from Arabidopsis thaliana reveals a conserved helical region unique to plants

(2009) Siew Leong Chan et al.   PROTEIN SCIENCE

Microbial TIR domains: not necessarily agents of subversion?

(2009) Abigail M. Spear et al.   TRENDS IN MICROBIOLOGY

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE