BRD4 Inhibition Attenuates Inflammatory Pain by Ameliorating NLRP3 Inflammasome-Induced Pyroptosis

Downregulation of HOTAIR reduces neuronal pyroptosis by targeting miR-455-3p/NLRP1 axis in propofol-treated neurons in vitro

(2021) Haixia Gong et al.   NEUROCHEMICAL RESEARCH

JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS

(2021) Ling Chen et al.   Frontiers in Immunology

S100A4 in Spinal Substantia Gelatinosa from Dorsal Root Ganglia Modulates Neuropathic Pain in a Rodent Spinal Nerve Injury Model

(2021) Xin Jiang et al.   Journal of Pain Research

Combined inhibition of histone deacetylases and BET family proteins as epigenetic therapy for nerve injury-induced neuropathic pain

(2021) Vittoria Borgonetti et al.   PHARMACOLOGICAL RESEARCH

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

(2021) Xiaojuan Han et al.   Redox Biology

Inhibitory effects of JQ1 on listeria monocytogenes-induced acute liver injury by blocking BRD4/RIPK1 axis

(2020) Zhao Qian et al.   BIOMEDICINE & PHARMACOTHERAPY

Muscone relieves inflammatory pain by inhibiting microglial activation-mediated inflammatory response via abrogation of the NOX4/JAK2-STAT3 pathway and NLRP3 inflammasome

(2020) Shanshan Yu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Inhibition of BRD4 prevents proliferation and epithelial–mesenchymal transition in renal cell carcinoma via NLRP3 inflammasome-induced pyroptosis

(2020) Yi-Fan Tan et al.   Cell Death & Disease

Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk

(2020) Junting Huang et al.   Cell Reports

Perioperative opioid analgesia—when is enough too much? A review of opioid-induced tolerance and hyperalgesia

(2019) Lesley A Colvin et al.   LANCET

Analgesic Effect of Zanthoxylum nitidum Extract in Inflammatory Pain Models Through Targeting of ERK and NF-κB Signaling

(2019) Fenfen Qin et al.   Frontiers in Pharmacology

BET protein inhibition regulates cytokine production and promotes neuroprotection after spinal cord injury

(2019) Judith Sánchez-Ventura et al.   Journal of Neuroinflammation

Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain

(2018) Fang Gao et al.   BRAIN BEHAVIOR AND IMMUNITY

Spinal bromodomain-containing protein 4 contributes to neuropathic pain induced by HIV glycoprotein 120 with morphine in rats

(2018) Keiya Takahashi et al.   NEUROREPORT

NMDA Receptor Activation Underlies the Loss of Spinal Dorsal Horn Neurons and the Transition to Persistent Pain after Peripheral Nerve Injury

(2018) Perrine Inquimbert et al.   Cell Reports

Bromodomain and extraterminal domain-containing protein inhibition attenuates acute inflammation after spinal cord injury

(2018) Michelle D. Rudman et al.   EXPERIMENTAL NEUROLOGY

Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity

(2018) Ming-Dong Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

The suppression of bromodomain and extra-terminal domain inhibits vascular inflammation by blocking NF-κB and MAPK activation

(2016) Mingcheng Huang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease

(2016) Marco Magistri et al.   Current Alzheimer Research

BET Inhibition AttenuatesHelicobacter pylori–Induced Inflammatory Response by Suppressing Inflammatory Gene Transcription and Enhancer Activation

(2016) Jinjing Chen et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

RNA sequencing reveals distinct mechanisms underlying BET inhibitor JQ1-mediated modulation of the LPS-induced activation of BV-2 microglial cells

(2015) Kyoung Jung et al.   Journal of Neuroinflammation

Peripheral NLCR4 inflammasome participates in the genesis of acute inflammatory pain

(2015) Alexandre H. Lopes et al.   PAIN

Dual transcriptome sequencing reveals resistance of TLR4 ligand-activated bone marrow-derived macrophages to inflammation mediated by the BET inhibitor JQ1

(2015) Amitabh Das et al.   Scientific Reports

Emerging targets in neuroinflammation-driven chronic pain

(2014) Ru-Rong Ji et al.   NATURE REVIEWS DRUG DISCOVERY

Chronic pain epidemiology and its clinical relevance

(2013) O van Hecke et al.   BRITISH JOURNAL OF ANAESTHESIA

Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms

(2012) Christian A. von Hehn et al.   NEURON

Erythropoietin Reduces Neuronal Cell Death and Hyperalgesia Induced by Peripheral Inflammatory Pain in Neonatal Rats

(2011) Osama Mohamad et al.   Molecular Pain

Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions

(2010) Zhen-Zhong Xu et al.   NATURE MEDICINE

How Neuroimaging Studies Have Challenged Us to Rethink: Is Chronic Pain a Disease?

(2009) Irene Tracey et al.   JOURNAL OF PAIN