Current Barriers to Clinical Liver Xenotransplantation

Bridging to Allotransplantation – Is Pig Liver Xenotransplantation the Best Option?

(2021) Vladimir Lamm et al.   TRANSPLANTATION

Scientific and psychosocial ethical considerations for initial clinical trials of kidney xenotransplantation

(2021) Daniel J. Hurst et al.   XENOTRANSPLANTATION

Solid organ xenotransplantation at the interface between research and clinical development: Regulatory aspects

(2020) Henk‐Jan Schuurman et al.   XENOTRANSPLANTATION

A review of pig liver xenotransplantation: Current problems and recent progress

(2019) Xuan Zhang et al.   XENOTRANSPLANTATION

Justification of specific genetic modifications in pigs for clinical organ xenotransplantation

(2019) David K. C. Cooper et al.   XENOTRANSPLANTATION

The potential role of 3D-bioprinting in xenotransplantation

(2019) Ping Li et al.   Current Opinion in Organ Transplantation

Infectious disease risks in xenotransplantation

(2018) Jay A. Fishman   AMERICAN JOURNAL OF TRANSPLANTATION

Tissue Factor at the crossroad of coagulation and cell signaling

(2018) Hortensia Zelaya et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals?

(2018) Joachim Denner   Retrovirology

Xenoantigen Deletion and Chemical Immunosuppression Can Prolong Renal Xenograft Survival

(2018) Andrew B. Adams et al.   ANNALS OF SURGERY

Consistent success in life-supporting porcine cardiac xenotransplantation

(2018) Matthias Längin et al.   NATURE

Cardiac xenografts show reduced survival in the absence of transgenic human thrombomodulin expression in donor pigs

(2018) Avneesh K. Singh et al.   XENOTRANSPLANTATION

The Role of Costimulation Blockade in Solid Organ and Islet Xenotransplantation

(2017) Kannan P. Samy et al.   Journal of Immunology Research

The Effects of Exogenous Administration of Human Coagulation Factors Following Pig-to-Baboon Liver Xenotransplantation

(2016) N. Navarro-Alvarez et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A Bridge to Somewhere

(2016) Jigesh A. Shah et al.   ANNALS OF SURGERY

Pig Liver Xenotransplantation

(2016) David K. C. Cooper et al.   TRANSPLANTATION

Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft

(2016) Muhammad M. Mohiuddin et al.   Nature Communications

siRNA Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation

(2015) H. E. Ahrens et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig BMSCs Transfected with Human TFPI Combat Species Incompatibility and Regulate the Human TF Pathway in Vitro and in a Rodent Model

(2015) Hongchen Ji et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Porcine Extrahepatic Vascular Endothelial Asialoglycoprotein Receptor 1 Mediates Xenogeneic Platelet Phagocytosis In Vitro and in Human-to-Pig Ex Vivo Xenoperfusion

(2015) Anjan K. Bongoni et al.   TRANSPLANTATION

The need for xenotransplantation as a source of organs and cells for clinical transplantation

(2015) Burcin Ekser et al.   International Journal of Surgery

Increased transfusion-free survival following auxiliary pig liver xenotransplantation

(2014) Heidi Yeh et al.   XENOTRANSPLANTATION

Pig-to-baboon liver xenoperfusion utilizing GalTKO.hCD46 pigs and glycoprotein Ib blockade

(2014) John C. LaMattina et al.   XENOTRANSPLANTATION

Immunobiology of liver xenotransplantation

(2012) Burcin Ekser et al.   Expert Review of Clinical Immunology

Genetically-Engineered Pig-to-Baboon Liver Xenotransplantation: Histopathology of Xenografts and Native Organs

(2012) Burcin Ekser et al.   PLoS One

Mechanisms of Xenogeneic Baboon Platelet Aggregation and Phagocytosis by Porcine Liver Sinusoidal Endothelial Cells

(2012) Qiang Peng et al.   PLoS One

Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation

(2012) Burcin Ekser et al.   TRANSPLANT INTERNATIONAL

Up to 9-day survival and control of thrombocytopenia following alpha1,3-galactosyl transferase knockout swine liver xenotransplantation in baboons

(2012) Karen Kim et al.   XENOTRANSPLANTATION

Comparison of hematologic, biochemical, and coagulation parameters in α1,3-galactosyltransferase gene-knockout pigs, wild-type pigs, and four primate species

(2012) Burcin Ekser et al.   XENOTRANSPLANTATION

Controlling coagulation dysregulation in xenotransplantation

(2011) Peter J Cowan et al.   Current Opinion in Organ Transplantation

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Primary Porcine Kupffer Cell Phagocytosis of Human Platelets Involves the CD18 Receptor

(2011) Ray K. Chihara et al.   TRANSPLANTATION

ASGR1 expressed by porcine enriched liver sinusoidal endothelial cells mediates human platelet phagocytosis in vitro

(2011) Leela L. Paris et al.   XENOTRANSPLANTATION

Clinical pig liver xenotransplantation: how far do we have to go?

(2011) Burcin Ekser et al.   XENOTRANSPLANTATION

Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig-to-Primate Kidney Xenotransplantation

(2010) C. C. Lin et al.   AMERICAN JOURNAL OF TRANSPLANTATION

PILOT EVALUATION OF ANTI-GPIB EFFECTS ON PLATELET SEQUESTRATION IN AN EX VIVO XENOGENEIC PIG LIVER PERFUSION MODEL

(2010) L. Burdorf et al.   TRANSPLANTATION

Hepatic Function After Genetically Engineered Pig Liver Transplantation in Baboons

(2010) Burcin Ekser et al.   TRANSPLANTATION

The fate of human platelets perfused through the pig liver: implications for xenotransplantation

(2010) Christopher Burlak et al.   XENOTRANSPLANTATION

Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig-to-Baboon Xenotransplantation

(2009) C. Knosalla et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Impact of Thrombocytopenia on Survival of Baboons with Genetically Modified Pig Liver Transplants: Clinical Relevance

(2009) B. Ekser et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Platelets Influence Vascularized Organ Transplants from Start to Finish

(2008) A. D. Kirk et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pig Thrombomodulin Binds Human Thrombin but Is a Poor Cofactor for Activation of Human Protein C and TAFI

(2008) J. C. Roussel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Recombinant pig TFPI efficiently regulates human tissue factor pathways

(2008) K. F. Eddy Lee et al.   XENOTRANSPLANTATION