The Gut-Liver Axis in Health and Disease: The Role of Gut Microbiota-Derived Signals in Liver Injury and Regeneration

Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation

(2021) Naschla Gasaly et al.   Frontiers in Immunology

Role of the Gut Microbiota in Regulating Non-alcoholic Fatty Liver Disease in Children and Adolescents

(2021) Daisuke Tokuhara   Frontiers in Nutrition

Microbiota changes and intestinal microbiota transplantation in liver diseases and cirrhosis

(2020) Jasmohan S. Bajaj et al.   JOURNAL OF HEPATOLOGY

The Microbiome and Hepatocellular Carcinoma

(2020) Puru Rattan et al.   LIVER TRANSPLANTATION

THU-373-IL-6 trans-sginaling controls liver regeneration after partial hepatectomy

(2019) Nastaran Fazel Modares et al.   JOURNAL OF HEPATOLOGY

Alterations of gut microbiome in autoimmune hepatitis

(2019) Yiran Wei et al.   GUT

Pretreatment With Bacillus cereus Preserves Against D-Galactosamine-Induced Liver Injury in a Rat Model

(2019) Ya-Ting Li et al.   Frontiers in Microbiology

Lactobacillus helveticus R0052 alleviates liver injury by modulating gut microbiome and metabolome in d-galactosamine-treated rats

(2019) Qiangqiang Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

Microbial Contribution to the Human Metabolome: Implications for Health and Disease

(2019) William Van Treuren et al.   Annual Review of Pathology-Mechanisms of Disease

The role of microbiota in tissue repair and regeneration

(2019) Amin Shavandi et al.   Journal of Tissue Engineering and Regenerative Medicine

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Association Between Intestinal Microbiota Collected at Hospital Admission and Outcomes of Patients with Cirrhosis

(2018) Jasmohan S. Bajaj et al.   Clinical Gastroenterology and Hepatology

Bile Acid Metabolism in Liver Pathobiology

(2018) John Y. L. Chiang et al.   GENE EXPRESSION

Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

(2018) Cristina Gutiérrez-Vázquez et al.   IMMUNITY

Role of bile acids in the gut-liver axis

(2018) Kai Markus Schneider et al.   JOURNAL OF HEPATOLOGY

The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value

(2018) Ángel C. Roman et al.   PHARMACOLOGY & THERAPEUTICS

Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

(2018) Chi Ma et al.   SCIENCE

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Microbial tryptophan catabolites in health and disease

(2018) Henrik M. Roager et al.   Nature Communications

Bifidobacterium adolescentis CGMCC 15058 alleviates liver injury, enhances the intestinal barrier and modifies the gut microbiota in d-galactosamine-treated rats

(2018) Yating Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

(2017) Ruqi Tang et al.   GUT

Hepatostat: Liver regeneration and normal liver tissue maintenance

(2017) George K. Michalopoulos   HEPATOLOGY

Bile acids and their receptors during liver regeneration: “Dangerous protectors”

(2017) Grégory Merlen et al.   MOLECULAR ASPECTS OF MEDICINE

Bile acids and their receptors

(2017) Emmanuelle Martinot et al.   MOLECULAR ASPECTS OF MEDICINE

The gut microbiome and liver cancer: mechanisms and clinical translation

(2017) Le-Xing Yu et al.   Nature Reviews Gastroenterology & Hepatology

Protective Effect of Akkermansia muciniphila against Immune-Mediated Liver Injury in a Mouse Model

(2017) Wenrui Wu et al.   Frontiers in Microbiology

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Metabolites: messengers between the microbiota and the immune system

(2016) Maayan Levy et al.   GENES & DEVELOPMENT

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

(2016) Martin Kummen et al.   GUT

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Functional analysis of the relationship between intestinal microbiota and the expression of hepatic genes and pathways during the course of liver regeneration

(2016) Hui-Xin Liu et al.   JOURNAL OF HEPATOLOGY

Liver regeneration — mechanisms and models to clinical application

(2016) Stuart J. Forbes et al.   Nature Reviews Gastroenterology & Hepatology

Intestinal Short Chain Fatty Acids and their Link with Diet and Human Health

(2016) David Ríos-Covián et al.   Frontiers in Microbiology

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease

(2015) George K. Michalopoulos et al.   GASTROENTEROLOGY

PPARγand the Innate Immune System Mediate the Resolution of Inflammation

(2015) Amanda Croasdell et al.   PPAR Research

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Short-Chain Fatty Acid Receptor and Its Contribution to Glucagon-Like Peptide-1 Release

(2014) Izumi Kaji et al.   DIGESTION

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

(2014) Susagna Padrissa-Altés et al.   GUT

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Alterations of the human gut microbiome in liver cirrhosis

(2014) Nan Qin et al.   NATURE

Butyrate Protects Rat Liver against Total Hepatic Ischemia Reperfusion Injury with Bowel Congestion

(2014) Bin Liu et al.   PLoS One

The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition

(2014) Pamela V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Links between diet, gut microbiota composition and gut metabolism

(2014) Harry J. Flint et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

(2014) Catalin Chimerel et al.   Cell Reports

Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

(2013) Iker Uriarte et al.   GUT

The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice

(2013) Noémie Péan et al.   HEPATOLOGY

SIRT1 controls liver regeneration by regulating bile acid metabolism through farnesoid X receptor and mammalian target of rapamycin signaling

(2013) Juan L. García-Rodríguez et al.   HEPATOLOGY

Lactobacillus rhamnosus GG reduces hepatic TNFα production and inflammation in chronic alcohol-induced liver injury

(2013) Yuhua Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Butyrate protects liver against ischemia reperfusion injury by inhibiting nuclear factor kappa B activation in Kupffer cells

(2013) Ying-li Qiao et al.   JOURNAL OF SURGICAL RESEARCH

Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor  

(2013) S. Alex et al.   MOLECULAR AND CELLULAR BIOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The abundance and variety of carbohydrate-active enzymes in the human gut microbiota

(2013) Abdessamad El Kaoutari et al.   NATURE REVIEWS MICROBIOLOGY

Commensal Bacteria-Dependent Indole Production Enhances Epithelial Barrier Function in the Colon

(2013) Yosuke Shimada et al.   PLoS One

Colonic mucosal microbiome differs from stool microbiome in cirrhosis and hepatic encephalopathy and is linked to cognition and inflammation

(2012) Jasmohan S. Bajaj et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

External biliary drainage and liver regeneration after major hepatectomy

(2012) R. Otao et al.   BRITISH JOURNAL OF SURGERY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

(2012) Hong-Bo Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice

(2012) Lisheng Zhang et al.   HEPATOLOGY

Bacteria, Colonic Fermentation, and Gastrointestinal Health

(2012) George T. Macfarlane et al.   JOURNAL OF AOAC INTERNATIONAL

Receptor-specific regulation of ERK1/2 activation by members of the “free fatty acid receptor” family

(2012) Sandra Seljeset et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Effect of pre- and probiotics on liver regeneration after resection: a randomised, double-blind pilot study

(2012) N. Rayes et al.   Beneficial Microbes

Lactobacillus rhamnosus GG Treatment Potentiates Intestinal Hypoxia-Inducible Factor, Promotes Intestinal Integrity and Ameliorates Alcohol-Induced Liver Injury

(2011) Yuhua Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Characterization of fecal microbial communities in patients with liver cirrhosis

(2011) Yanfei Chen et al.   HEPATOLOGY

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Intestinal Microbiota Was Assessed in Cirrhotic Patients with Hepatitis B Virus Infection

(2011) Haifeng Lu et al.   MICROBIAL ECOLOGY

Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents

(2010) Le-Xing Yu et al.   HEPATOLOGY

The role of intestinal endotoxin in liver injury: A long and evolving history

(2010) James P. Nolan   HEPATOLOGY

Immediate neuroendocrine signaling after partial hepatectomy through acute portal hyperpressure and cholestasis

(2010) Isabelle Doignon et al.   JOURNAL OF HEPATOLOGY

Role of hepatic transporters in prevention of bile acid toxicity after partial hepatectomy in mice

(2009) Iván L. Csanaky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Isolation and characterization of a bile acid inducible 7α-dehydroxylating operon in Clostridium hylemonae TN271

(2009) Jason M. Ridlon et al.   ANAEROBE

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

Endotoxemia and gut barrier dysfunction in alcoholic liver disease

(2009) Radhakrishna Rao   HEPATOLOGY

The bacterial signal indole increases epithelial-cell tight-junction resistance and attenuates indicators of inflammation

(2009) T. Bansal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA