A Microbe-Derived Efflux Pump Inhibitor of the Resistance-Nodulation-Cell Division Protein Restores Antibiotic Susceptibility in Escherichia coli and Pseudomonas aeruginosa

Design, synthesis and evaluation of a series of 5-methoxy-2,3-naphthalimide derivatives as AcrB inhibitors for the reversal of bacterial resistance

(2019) Chaobin Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition in Staphylococcus aureus

(2019) Rushikesh Tambat et al.   Frontiers in Microbiology

Kinetic analysis of the inhibition of the drug efflux protein AcrB using surface plasmon resonance

(2018) Rumana Mowla et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Identification of a Novel Polyamine Scaffold With Potent Efflux Pump Inhibition Activity Toward Multi-Drug Resistant Bacterial Pathogens

(2018) Renee M. Fleeman et al.   Frontiers in Microbiology

Optimized arylomycins are a new class of Gram-negative antibiotics

(2018) Peter A. Smith et al.   NATURE

The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

(2018) Michael Luke Carlson et al.   eLife

Intrinsic, adaptive and acquired antimicrobial resistance in Gram-negative bacteria

(2017) Mohsen Arzanlou et al.   Essays in Biochemistry

The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition

(2017) Tapas Bhattacharyya et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

(2017) Diana Machado et al.   PeerJ

Ion Channel Blockers as Antimicrobial Agents, Efflux Inhibitors, and Enhancers of Macrophage Killing Activity against Drug Resistant Mycobacterium tuberculosis

(2016) Diana Machado et al.   PLoS One

Gallic acid-based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli

(2015) Gaurav Raj Dwivedi et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

Enhancement of Antibiotic Activity against Multidrug-Resistant Bacteria by the Efflux Pump Inhibitor 3,4-Dibromopyrrole-2,5-dione Isolated from a Pseudoalteromonas sp.

(2015) Kristen E. Whalen et al.   JOURNAL OF NATURAL PRODUCTS

Recent advances toward a molecular mechanism of efflux pump inhibition

(2015) Timothy J. Opperman et al.   Frontiers in Microbiology

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-Line Antibiotics against Multidrug-Resistant Gram-Negative Bacteria

(2015) Kade D. Roberts et al.   ACS Infectious Diseases

Identification of Acinetobacter baumannii Serum-Associated Antibiotic Efflux Pump Inhibitors

(2014) Catlyn Blanchard et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Mechanism of MBX2319 Inhibition of Escherichia coli AcrB Multidrug Efflux Pump and Comparison with Other Inhibitors

(2014) Attilio V. Vargiu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ramoplanin at Bactericidal Concentrations Induces Bacterial Membrane Depolarization in Staphylococcus aureus

(2014) Mu Cheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Something old, something new: revisiting natural products in antibiotic drug discovery

(2014) Gerard D. Wright   CANADIAN JOURNAL OF MICROBIOLOGY

Update on the antibiotic resistance crisis

(2014) Gian Maria Rossolini et al.   CURRENT OPINION IN PHARMACOLOGY

Efflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them

(2014) Leonard Amaral et al.   Frontiers in Pharmacology

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria

(2013) Ryan P. Lamers et al.   PLoS One

Combination approaches to combat multidrug-resistant bacteria

(2013) Roberta J. Worthington et al.   TRENDS IN BIOTECHNOLOGY

Role of efflux pumps in the antibiotic resistance of bacteria embedded in a biofilm

(2013) Sara M. Soto   Virulence

Microbial Efflux Pump Inhibition: Tactics and Strategies

(2012) George P. Tegos et al.   CURRENT PHARMACEUTICAL DESIGN

Capsaicin, a novel inhibitor of the NorA efflux pump, reduces the intracellular invasion of Staphylococcus aureus

(2012) N. P. Kalia et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa

(2011) Momen Askoura et al.   Libyan Journal of Medicine

Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket

(2011) Ryosuke Nakashima et al.   NATURE

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

(2011) Linda Ejim et al.   Nature Chemical Biology

A 96-well plate fluorescence assay for assessment of cellular permeability and active efflux in Salmonella enterica serovar Typhimurium and Escherichia coli

(2010) N. G. Coldham et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Hospital-Acquired Infections Due to Gram-Negative Bacteria

(2010) Anton Y. Peleg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Assembly and transport mechanism of tripartite drug efflux systems

(2009) Rajeev Misra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa

(2009) Yoichi Hirakata et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Assessment by Time-Kill Methodology of the Synergistic Effects of Oritavancin in Combination with Other Antimicrobial Agents against Staphylococcus aureus

(2008) A. Belley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inactivation of Efflux Pumps Abolishes Bacterial Biofilm Formation

(2008) M. Kvist et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Efflux-mediated response of Staphylococcus aureus exposed to ethidium bromide

(2008) I. Couto et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Site-Directed Mutagenesis Reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB

(2008) J. A. Bohnert et al.   JOURNAL OF BACTERIOLOGY