Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses
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Title
Minor Cannabinoids: Biosynthesis, Molecular Pharmacology and Potential Therapeutic Uses
Authors
Keywords
-
Journal
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-12-01
DOI
10.3389/fphar.2021.777804
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Note: Only part of the references are listed.- Cannabis-Derived Compounds Cannabichromene and Δ9-Tetrahydrocannabinol Interact and Exhibit Cytotoxic Activity against Urothelial Cell Carcinoma Correlated with Inhibition of Cell Migration and Cytoskeleton Organization
- (2021) Omer Anis et al. MOLECULES
- Induced Fit Docking and Automated QSAR Studies Reveal the ER-α Inhibitory Activity of Cannabis sativa in Breast Cancer
- (2021) Babatomiwa Kikiowo et al. Recent Patents on Anti-Cancer Drug Discovery
- SNP in Potentially Defunct Tetrahydrocannabinolic Acid Synthase Is a Marker for Cannabigerolic Acid Dominance in Cannabis sativa L.
- (2021) Andrea R. Garfinkel et al. Genes
- The fundamental role of the endocannabinoid system in endometrium and placenta: implications in pathophysiological aspects of uterine and pregnancy disorders
- (2020) J Maia et al. HUMAN REPRODUCTION UPDATE
- Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors
- (2020) Gemma Navarro et al. PHARMACOLOGICAL RESEARCH
- Evaluation of repeated or acute treatment with cannabidiol (CBD), cannabidiolic acid (CBDA) or CBDA methyl ester (HU-580) on nausea and/or vomiting in rats and shrews
- (2020) Erin M. Rock et al. PSYCHOPHARMACOLOGY
- Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors
- (2020) David B. Finlay et al. Frontiers in Pharmacology
- The synthetic cannabinoids phenomenon: from structure to toxicological properties. A review
- (2020) Vera L. Alves et al. CRITICAL REVIEWS IN TOXICOLOGY
- Phytocannabinoids: Origins and Biosynthesis
- (2020) Thies Gülck et al. TRENDS IN PLANT SCIENCE
- Molecular Pharmacology of Synthetic Cannabinoids: Delineating CB1 Receptor-Mediated Cell Signaling
- (2020) Kenneth B. Walsh et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- CBD and THC: Do they complement each other like yin and yang?
- (2020) Sarah D. Pennypacker et al. PHARMACOTHERAPY
- Efficacy of combined therapy with fish oil and phytocannabinoids in murine intestinal inflammation
- (2020) Ester Pagano et al. PHYTOTHERAPY RESEARCH
- Cannabidiolic acid exhibits entourage-like improvements of anticonvulsant activity in an acute rat model of seizures
- (2020) Brett Goerl et al. EPILEPSY RESEARCH
- Δ9-Tetrahydrocannabinolic Acid markedly alleviates liver fibrosis and inflammation in mice
- (2020) Beatriz Carmona-Hidalgo et al. PHYTOMEDICINE
- Identification of a new cannabidiol n-hexyl homolog in a medicinal cannabis variety with an antinociceptive activity in mice: cannabidihexol
- (2020) Pasquale Linciano et al. Scientific Reports
- In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
- (2020) Ayat Zagzoog et al. Scientific Reports
- Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
- (2019) Kaavya Krishna Kumar et al. CELL
- Complete biosynthesis of cannabinoids and their unnatural analogues in yeast
- (2019) Xiaozhou Luo et al. NATURE
- Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System
- (2019) Kinga Tóth et al. MOLECULES
- Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach
- (2019) Enrico D'Aniello et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Dark Classics in Chemical Neuroscience: Δ9-Tetrahydrocannabinol
- (2019) Samuel D. Banister et al. ACS Chemical Neuroscience
- Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain
- (2019) Hayes Wong et al. ARCHIVES OF ORAL BIOLOGY
- Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male Mecp2 mutant mice
- (2019) Erica Zamberletti et al. JOURNAL OF PSYCHOPHARMACOLOGY
- Cannabichromene is a cannabinoid CB2 receptor agonist
- (2019) Michael Udoh et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabidivarin Treatment Ameliorates Autism-Like Behaviors and Restores Hippocampal Endocannabinoid System and Glia Alterations Induced by Prenatal Valproic Acid Exposure in Rats
- (2019) Erica Zamberletti et al. Frontiers in Cellular Neuroscience
- From Cannabinoids and Neurosteroids to Statins and the Ketogenic Diet: New Therapeutic Avenues in Rett Syndrome?
- (2019) Francisco Melo Mouro et al. Frontiers in Neuroscience
- Pharmacokinetics of Phytocannabinoid Acids and Anticonvulsant Effect of Cannabidiolic Acid in a Mouse Model of Dravet Syndrome
- (2019) Lyndsey L. Anderson et al. JOURNAL OF NATURAL PRODUCTS
- Tetrahydrocannabinolic acid A (THCA-A) reduces adiposity and prevents metabolic disease caused by diet-induced obesity
- (2019) Belén Palomares et al. BIOCHEMICAL PHARMACOLOGY
- A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol
- (2019) Cinzia Citti et al. Scientific Reports
- Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol
- (2018) Antonella Smeriglio et al. FITOTERAPIA
- In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid
- (2018) Agnese Gugliandolo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Cannabis for Chronic Pain: Challenges and Considerations
- (2018) E. Alfonso Romero-Sandoval et al. PHARMACOTHERAPY
- Cannabigerol Action at Cannabinoid CB1 and CB2 Receptors and at CB1–CB2 Heteroreceptor Complexes
- (2018) Gemma Navarro et al. Frontiers in Pharmacology
- Effects of non-euphoric plant cannabinoids on muscle quality and performance of dystrophic mdx mice
- (2018) Fabio Arturo Iannotti et al. BRITISH JOURNAL OF PHARMACOLOGY
- Inhibitory effects of cannabidiol on voltage-dependent sodium currents
- (2018) Mohammad-Reza Ghovanloo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Chronic treatment with the phytocannabinoid Cannabidivarin (CBDV) rescues behavioural alterations and brain atrophy in a mouse model of Rett syndrome
- (2018) Daniele Vigli et al. NEUROPHARMACOLOGY
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- (2018) Erin M. Rock et al. PSYCHOPHARMACOLOGY
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- Medical Use of Cannabinoids
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- (2018) S. Pisanti et al. JOURNAL OF CELLULAR PHYSIOLOGY
- The current status of artisanal cannabis for the treatment of epilepsy in the United States
- (2017) Dustin Sulak et al. EPILEPSY & BEHAVIOR
- Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration
- (2017) Katherine A. Scott et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Crystal structures of agonist-bound human cannabinoid receptor CB1
- (2017) Tian Hua et al. NATURE
- An Introduction to the Endogenous Cannabinoid System
- (2016) Hui-Chen Lu et al. BIOLOGICAL PSYCHIATRY
- Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study
- (2016) Khalid A. Jadoon et al. DIABETES CARE
- Differential effectiveness of selected non-psychotropic phytocannabinoids on human sebocyte functions implicates their introduction in dry/seborrhoeic skin and acne treatment
- (2016) Attila Oláh et al. EXPERIMENTAL DERMATOLOGY
- Phytocannabinoids: a unified critical inventory
- (2016) Lumír Ondřej Hanuš et al. NATURAL PRODUCT REPORTS
- Pure Δ 9 -tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ 9 -tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages
- (2016) Barbara Romano et al. PHARMACOLOGICAL RESEARCH
- Identification of dual PPARα/γ agonists and their effects on lipid metabolism
- (2015) Quanqing Gao et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Evolution and Classification of Cannabis sativa (Marijuana, Hemp) in Relation to Human Utilization
- (2015) Ernest Small BOTANICAL REVIEW
- The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act through 5-HT1Areceptors to produce antipsychotic effects
- (2015) Maria Grazia Cascio et al. BRITISH JOURNAL OF PHARMACOLOGY
- Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers
- (2015) Luke Tudge et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid
- (2014) Francesca Borrelli et al. CARCINOGENESIS
- Evaluation of phytocannabinoids from high-potency Cannabis sativa using in vitro bioassays to determine structure–activity relationships for cannabinoid receptor 1 and cannabinoid receptor 2
- (2014) Afeef S. Husni et al. MEDICINAL CHEMISTRY RESEARCH
- Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice
- (2014) Sara Valdeolivas et al. Neurotherapeutics
- Differences in receptor binding affinity of several phytocannabinoids do not explain their effects on neural cell cultures
- (2014) Sarah Rosenthaler et al. NEUROTOXICOLOGY AND TERATOLOGY
- A Cannabigerol Derivative Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis
- (2014) Francisco J. Carrillo-Salinas et al. PLoS One
- Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease
- (2013) Francesca Borrelli et al. BIOCHEMICAL PHARMACOLOGY
- Tetrahydrocannabinolic acid reduces nausea-induced conditioned gaping in rats and vomiting inSuncus murinus
- (2013) E M Rock et al. BRITISH JOURNAL OF PHARMACOLOGY
- Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ9-tetrahydrocannabivarin (THCV), to produce CB1receptor inverse agonism symptoms of nausea in rats
- (2013) Erin M Rock et al. BRITISH JOURNAL OF PHARMACOLOGY
- The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis
- (2013) B Romano et al. BRITISH JOURNAL OF PHARMACOLOGY
- Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)
- (2013) Kwang H. Ahn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The effect of cannabichromene on adult neural stem/progenitor cells
- (2013) Noriko Shinjyo et al. NEUROCHEMISTRY INTERNATIONAL
- Suppression of lithium chloride-induced conditioned gaping (a model of nausea-induced behaviour) in rats (using the taste reactivity test) with metoclopramide is enhanced by cannabidiolic acid
- (2013) E.M. Rock et al. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Attenuation of anticipatory nausea in a rat model of contextually elicited conditioned gaping by enhancement of the endocannabinoid system
- (2013) Cheryl L. Limebeer et al. PSYCHOPHARMACOLOGY
- The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity
- (2013) E T Wargent et al. Nutrition & Diabetes
- Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
- (2013) Naoki Amada et al. PeerJ
- Cannabidivarin is anticonvulsant in mouse and rat
- (2012) AJ Hill et al. BRITISH JOURNAL OF PHARMACOLOGY
- A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons
- (2012) Luciano De Petrocellis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
- (2012) Angelo A Izzo et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabidiolic acid prevents vomiting inSuncus murinusand nausea-induced behaviour in rats by enhancing 5-HT1Areceptor activation
- (2012) D Bolognini et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
- (2012) Rudolf Moldzio et al. PHYTOMEDICINE
- Cannabinol and cannabidiol exert opposing effects on rat feeding patterns
- (2012) Jonathan A. Farrimond et al. PSYCHOPHARMACOLOGY
- Non-Δ9tetrahydrocannabinol phytocannabinoids stimulate feeding in rats
- (2011) Jonathan A. Farrimond et al. BEHAVIOURAL PHARMACOLOGY
- Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
- (2011) Lucia Renee Ruhaak et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ9-THCV in animal models of Parkinson's disease
- (2011) C García et al. BRITISH JOURNAL OF PHARMACOLOGY
- Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects
- (2011) Ethan B Russo BRITISH JOURNAL OF PHARMACOLOGY
- Modulation of l-α-Lysophosphatidylinositol/GPR55 Mitogen-activated Protein Kinase (MAPK) Signaling by Cannabinoids
- (2011) Sharon Anavi-Goffer et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease
- (2011) Onintza Sagredo et al. JOURNAL OF NEUROSCIENCE RESEARCH
- The plant cannabinoid Δ9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice
- (2010) Daniele Bolognini et al. BRITISH JOURNAL OF PHARMACOLOGY
- Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
- (2010) Sabatino Maione et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effects of cannabinoids and cannabinoid-enrichedCannabisextracts on TRP channels and endocannabinoid metabolic enzymes
- (2010) Luciano De Petrocellis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Pharmacological evaluation of the natural constituent of Cannabis sativa, cannabichromene and its modulation by Δ9-tetrahydrocannabinol☆
- (2010) Gerald T. DeLong et al. DRUG AND ALCOHOL DEPENDENCE
- Δ9-Tetrahydrocannabivarin suppresses in vitro epileptiform and in vivo seizure activity in adult rats
- (2010) Andrew J. Hill et al. EPILEPSIA
- Comparative topical anti-inflammatory activity of cannabinoids and cannabivarins
- (2010) Aurelia Tubaro et al. FITOTERAPIA
- Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
- (2010) Nephi Stella GLIA
- Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
- (2009) MG Cascio et al. BRITISH JOURNAL OF PHARMACOLOGY
- Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
- (2009) Gernot Riedel et al. BRITISH JOURNAL OF PHARMACOLOGY
- Effects of Δ9-tetrahydrocannabivarin on [35S]GTPγS binding in mouse brain cerebellum and piriform cortex membranes
- (2008) I Dennis et al. BRITISH JOURNAL OF PHARMACOLOGY
- Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis
- (2008) S. Takeda et al. DRUG METABOLISM AND DISPOSITION
- The inheritance of chemical phenotype in Cannabis sativa L. (III): variation in cannabichromene proportion
- (2008) E. P. M. de Meijer et al. EUPHYTICA
- The GPR55 ligand l-α-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation
- (2008) Christopher M. Henstridge et al. FASEB JOURNAL
- Inhibition of Recombinant Human T-type Calcium Channels by Δ9-Tetrahydrocannabinol and Cannabidiol
- (2008) Hamish Redmond Ross et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Antibacterial Cannabinoids fromCannabis sativa: A Structure−Activity Study
- (2008) Giovanni Appendino et al. JOURNAL OF NATURAL PRODUCTS
- Plant-Derived Cannabinoids Modulate the Activity of Transient Receptor Potential Channels of Ankyrin Type-1 and Melastatin Type-8
- (2008) L. De Petrocellis et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors
- (2007) S E O'Sullivan BRITISH JOURNAL OF PHARMACOLOGY
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