A FAK Inhibitor Boosts Anti-PD1 Immunotherapy in a Hepatocellular Carcinoma Mouse Model
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Title
A FAK Inhibitor Boosts Anti-PD1 Immunotherapy in a Hepatocellular Carcinoma Mouse Model
Authors
Keywords
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Journal
Frontiers in Pharmacology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-01-18
DOI
10.3389/fphar.2021.820446
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Note: Only part of the references are listed.- TNIK is a therapeutic target in Lung Squamous Cell Carcinoma and regulates FAK activation through Merlin.
- (2021) Pedro Torres-Ayuso et al. Cancer Discovery
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- (2021) Delphine M. Lees et al. ANGIOGENESIS
- FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation
- (2021) Kyuho Jeong et al. CARDIOVASCULAR RESEARCH
- Advances in immunotherapy for hepatocellular carcinoma
- (2021) Bruno Sangro et al. Nature Reviews Gastroenterology & Hepatology
- Focal adhesion kinase (FAK) promotes cholangiocarcinoma development and progression via YAP activation
- (2021) Xinhua Song et al. JOURNAL OF HEPATOLOGY
- Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma
- (2020) Jiuwei Zhang et al. DNA AND CELL BIOLOGY
- Challenges of combination therapy with immune checkpoint inhibitors for hepatocellular carcinoma
- (2020) Ann-Lii Cheng et al. JOURNAL OF HEPATOLOGY
- T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity
- (2020) Marta Canel et al. eLife
- Impact of FAK Expression on the Cytotoxic Effects of CIK Therapy in Triple-Negative Breast Cancer
- (2020) Mei-Ren Pan et al. Cancers
- Acquired Resistance to Immune Checkpoint Inhibitors
- (2020) Adam J. Schoenfeld et al. CANCER CELL
- FAK-targeted and combination therapies for the treatment of cancer: an overview of phase I and II clinical trials
- (2020) Atish Mohanty et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- TIMER2.0 for analysis of tumor-infiltrating immune cells
- (2020) Taiwen Li et al. NUCLEIC ACIDS RESEARCH
- Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial
- (2020) Robert J Motzer et al. Journal for ImmunoTherapy of Cancer
- Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
- (2020) Andrew L. Ji et al. CELL
- Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies
- (2019) Maja J. A. de Jonge et al. Targeted Oncology
- MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1
- (2019) Hui Li et al. GASTROENTEROLOGY
- Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance
- (2019) Jonathan Cooper et al. CANCER CELL
- Management of adverse events associated with tyrosine kinase inhibitors: Improving outcomes for patients with hepatocellular carcinoma
- (2019) Lorenza Rimassa et al. CANCER TREATMENT REVIEWS
- High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma
- (2019) Sarah Wang et al. CLINICAL CANCER RESEARCH
- Development of resistance to FAK inhibition in pancreatic cancer is linked to stromal depletion
- (2019) Hong Jiang et al. GUT
- Oncofetal HLF transactivates c-Jun to promote hepatocellular carcinoma development and sorafenib resistance
- (2019) Dai-Min Xiang et al. GUT
- Cell-intrinsic PD-1 promotes proliferation in pancreatic cancer by targeting CYR61/CTGF via the hippo pathway
- (2019) Ning Pu et al. CANCER LETTERS
- A global view of hepatocellular carcinoma: trends, risk, prevention and management
- (2019) Ju Dong Yang et al. Nature Reviews Gastroenterology & Hepatology
- Small molecule immunomodulation: the tumor microenvironment and overcoming immune escape
- (2019) Arsen Osipov et al. Journal for ImmunoTherapy of Cancer
- Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy
- (2019) Huiying Han et al. CANCER CELL
- Tumour evolution in hepatocellular carcinoma
- (2019) Amanda J. Craig et al. Nature Reviews Gastroenterology & Hepatology
- An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
- (2018) Jianfang Liu et al. CELL
- β-catenin deficiency in hepatocytes aggravates hepatocarcinogenesis driven by oncogenic β-catenin and MET
- (2018) Yan Liang et al. HEPATOLOGY
- Immune checkpoint therapy in liver cancer
- (2018) Feng Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial
- (2018) Andrew X Zhu et al. LANCET ONCOLOGY
- A Study of the Focal Adhesion Kinase Inhibitor GSK2256098 in Patients with Recurrent Glioblastoma with Evaluation of Tumor Penetration of [11C]GSK2256098
- (2018) Nicholas F Brown et al. NEURO-ONCOLOGY
- The tumour microenvironment creates a niche for the self-renewal of tumour-promoting macrophages in colon adenoma
- (2018) Irene Soncin et al. Nature Communications
- Identification of a novel anoikis signalling pathway using the fungal virulence factor gliotoxin
- (2018) Florian Haun et al. Nature Communications
- Cancer Cell-Intrinsic PD-1 and Implications in Combinatorial Immunotherapy
- (2018) Han Yao et al. Frontiers in Immunology
- GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts
- (2018) Rosalie M. Sterner et al. BLOOD
- Targeted and Immune-Based Therapies for Hepatocellular Carcinoma
- (2018) Tim F. Greten et al. GASTROENTEROLOGY
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- IL-33 and ST2 mediate FAK-dependent antitumor immune evasion through transcriptional networks
- (2017) Bryan Serrels et al. Science Signaling
- Histidine decarboxylase (HDC)-expressing granulocytic myeloid cells induce and recruit Foxp3+ regulatory T cells in murine colon cancer
- (2017) Xiaowei Chen et al. OncoImmunology
- Liver immunology and its role in inflammation and homeostasis
- (2016) Mark W Robinson et al. Cellular & Molecular Immunology
- FAK Kinase Activity Is Required for the Progression of c-MET/β-Catenin-Driven Hepataocellular Carcinoma
- (2016) Na Shang et al. GENE EXPRESSION
- Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
- (2016) Hong Jiang et al. NATURE MEDICINE
- FAK Is required for c-Met/β-catenin-driven hepatocarcinogenesis
- (2014) Na Shang et al. HEPATOLOGY
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
- (2012) Paolo P. Provenzano et al. CANCER CELL
- Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses
- (2012) J. B. Mitchem et al. CANCER RESEARCH
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