Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses

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(2021) Min Liu et al.   MOLECULAR NEUROBIOLOGY

Isoliquritin exert protective effect on telencephalon infarction injury by regulating multi-pathways in zebrafish model of ischemic stroke

(2021) Xiao-Huan Zhang et al.   PHYTOMEDICINE

MiR-27a-3p suppresses cerebral ischemia-reperfusion injury by targeting FOXO1

(2021) Wenyu Li et al.   Aging-US

Withania coagulans extract attenuates oxidative stress-mediated apoptosis of cerebellar purkinje neurons after ischemia/reperfusion injury

(2021) Zahra Heidari et al.   METABOLIC BRAIN DISEASE

Classical Active Ingredients and Extracts of Chinese Herbal Medicines: Pharmacokinetics, Pharmacodynamics, and Molecular Mechanisms for Ischemic Stroke

(2021) Ting Zhu et al.   Oxidative Medicine and Cellular Longevity

Danggui-Shaoyao-San (DSS) Ameliorates Cerebral Ischemia-Reperfusion Injury via Activating SIRT1 Signaling and Inhibiting NADPH Oxidases

(2021) Yunxia Luo et al.   Frontiers in Pharmacology

Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium

(2021) Kohei Homma et al.   Redox Biology

Melatonin rescues cerebral ischemic events through upregulated tunneling nanotube-mediated mitochondrial transfer and downregulated mitochondrial oxidative stress in rat brain

(2021) Hon-Kan Yip et al.   BIOMEDICINE & PHARMACOTHERAPY

A Network Pharmacology Approach for Exploring the Mechanisms of Panax notoginseng Saponins in Ischaemic Stroke

(2021) Cong Wang et al.   Evidence-based Complementary and Alternative Medicine

TNF-α Receptor Inhibitor Alleviates Metabolic and Inflammatory Changes in a Rat Model of Ischemic Stroke

(2021) Shih-Yi Lin et al.   Antioxidants

Synthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury

(2020) Liping Liao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

(2020) Shengpan Chen et al.   Journal of Neuroinflammation

Quercetin protects against cerebral ischemia/reperfusion and oxygen glucose deprivation/Reoxygenation neurotoxicity

(2020) Ya-Yu Wang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Improvement of cerebral ischemia/reperfusion injury by daucosterol palmitate-induced neuronal apoptosis inhibition via PI3K/Akt/mTOR signaling pathway

(2020) Huiyuan Zhang et al.   METABOLIC BRAIN DISEASE

Ischemic postconditioning exerts neuroprotective effect through negatively regulating PI3K/Akt2 signaling pathway by microRNA-124

(2020) Wei Miao et al.   BIOMEDICINE & PHARMACOTHERAPY

Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury

(2020) Han Wang et al.   Journal of Neuroinflammation

Memory-Enhancing Effect of a Phytosome Containing the Combined Extract of Mulberry Fruit and Ginger in an Animal Model of Ischemic Stroke with Metabolic Syndrome

(2020) Jintanaporn Wattanathorn et al.   Oxidative Medicine and Cellular Longevity

Neuroprotection by Phytoestrogens in the Model of Deprivation and Resupply of Oxygen and Glucose In Vitro: The Contribution of Autophagy and Related Signaling Mechanisms

(2020) Giuseppe Abbruzzese et al.   Antioxidants

Ablation of TMEM126B protects against oxygen-glucose deprivation/reoxygenation-induced injuries of PC12 cells via maintaining mitochondrial anti-apoptotic functions

(2020) Lihong Wei et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

MicroRNA‐182 exacerbates blood‐brain barrier (BBB) disruption by downregulating the mTOR/FOXO1 pathway in cerebral ischemia

(2020) Tongshuai Zhang et al.   FASEB JOURNAL

Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

(2020) Haidong Wang et al.   LANCET

Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway

(2020) Shuwen Liu et al.   NEUROCHEMICAL RESEARCH

Blood biomarkers indicate that the preclinical stages of Alzheimer's disease present overlapping molecular features

(2020) Alfonso Di Costanzo et al.   Scientific Reports

Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGFβ/ALK1/Smad1/5 signaling pathway

(2020) Jin Du et al.   Aging-US

Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis

(2020) Katherine A. Veleta et al.   CELL DEATH AND DIFFERENTIATION

Solvent effect on phenolics and antioxidant activity of Huangshan Gongju (Dendranthema morifolium (Ramat) Tzvel. cv. Gongju) extract

(2020) Yi-Long Ma et al.   FOOD AND CHEMICAL TOXICOLOGY

Silencing PAQR3 protects against oxygen-glucose deprivation/reperfusion-induced neuronal apoptosis via activation of PI3K/AKT signaling in PC12 cells

(2020) Shanshan Qiao et al.   LIFE SCIENCES

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

(2020) Obolenskaia Olga Nikolaevna et al.   Antioxidants

Curcumin and Solid Lipid Curcumin Particles Induce Autophagy, but Inhibit Mitophagy and the PI3K-Akt/mTOR Pathway in Cultured Glioblastoma Cells

(2019) Panchanan Maiti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hollow Prussian Blue Nanozymes Drive Neuroprotection against Ischemic Stroke via Attenuating Oxidative Stress, Counteracting Inflammation, and Suppressing Cell Apoptosis

(2019) Kai Zhang et al.   NANO LETTERS

Antithrombotics from the Sea: Polysaccharides and Beyond

(2019) Francisca Carvalhal et al.   Marine Drugs

Neuroprotective effect of ginkgetin in experimental cerebral ischemia/reperfusion via apoptosis inhibition and PI3K/Akt/mTOR signaling pathway activation

(2019) Zhaohua Tian et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The DisGeNET knowledge platform for disease genomics: 2019 update

(2019) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

DPP-4 Inhibitor Linagliptin is Neuroprotective in Hyperglycemic Mice with Stroke via the AKT/mTOR Pathway and Anti-apoptotic Effects

(2019) Gang Zhang et al.   Neuroscience Bulletin

Correction: Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles. Pharmaceutics, 2019, 11(9), 478

(2019) Takanori Kanazawa et al.   Pharmaceutics

The protective effect of Lonicera japonica polysaccharide on mice with depression by inhibiting NLRP3 inflammasome

(2019) Ping Liu et al.   Annals of Translational Medicine

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

(2018) Peiying Li et al.   NEUROPHARMACOLOGY

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(2018) Hai-Yu Xu et al.   NUCLEIC ACIDS RESEARCH

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Apigenin Protects the Brain against Ischemia/Reperfusion Injury via Caveolin-1/VEGF In Vitro and In Vivo

(2018) Qiongyi Pang et al.   Oxidative Medicine and Cellular Longevity

PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database

(2017) Xia Wang et al.   NUCLEIC ACIDS RESEARCH

The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion

(2017) Liying Yang et al.   Experimental and Therapeutic Medicine

Promotion effect of extracts from plastrum testudinis on alendronate against glucocorticoid-induced osteoporosis in rat spine

(2017) Hui Ren et al.   Scientific Reports

PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectives

(2016) Vivek Asati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Blood-Spinal Cord Barrier Alterations in Subacute and Chronic Stages of a Rat Model of Focal Cerebral Ischemia

(2016) Svitlana Garbuzova-Davis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Panax notoginseng saponins administration modulates pro- /anti-inflammatory factor expression and improves neurologic outcome following permanent MCAO in rats

(2016) Xiaowei Shi et al.   METABOLIC BRAIN DISEASE

Effect of recombinant plasminogen activator timing on thrombolysis in a novel rat embolic stroke model

(2016) Yinzhong Ma et al.   PHARMACOLOGICAL RESEARCH

Targeting a novel cancer-driving protein (LAPTM4B-35) by a small molecule (ETS) to inhibit cancer growth and metastasis

(2016) Maojin Li et al.   Oncotarget

BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine

(2016) Zhongyang Liu et al.   Scientific Reports

Acute Stroke Intervention

(2015) Shyam Prabhakaran et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Detrimental role of pericyte Nox4 in the acute phase of brain ischemia

(2015) Ataru Nishimura et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ligustrazine monomer against cerebral ischemia-reperfusion injury

(2015) Qing-chun Mu et al.   Neural Regeneration Research

OMIM.org: Online Mendelian Inheritance in Man (OMIM®), an online catalog of human genes and genetic disorders

(2014) Joanna S. Amberger et al.   NUCLEIC ACIDS RESEARCH

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Traumatic Brain Injury: Oxidative Stress and Neuroprotection

(2013) Carolin Cornelius et al.   ANTIOXIDANTS & REDOX SIGNALING

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols