Article
Biotechnology & Applied Microbiology
Lei Jin, Yun Mo, Er-Li Yue, Yuan Liu, Kang-Yong Liu
Summary: In conclusion, the study demonstrates that ibrutinib shows promising effects in improving cell viability under high glucose and H/R conditions, as well as reducing cerebral infarct volume, improving neurological deficits, and enhancing autophagy in diabetic mice suffering from I/R injury. Additionally, the neuroprotective effects of ibrutinib are associated with the regulation of PI3K/Akt/mTOR signaling pathway.
Article
Chemistry, Medicinal
Jiangbo Xie, Tingting Zhang, Peichun Li, Dong Wang, Tao Liu, Shunliang Xu
Summary: This study found that dihydromyricetin can alleviate cerebral ischemia reperfusion injury by inhibiting the SPHK1/mTOR signaling pathway and suppressing ferroptosis. These findings suggest that dihydromyricetin may be a potential drug for the treatment of cerebral ischemia reperfusion injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Immunology
Kongwei Guo, Yanxing Shang, Zhao Wang, Yu Li, Jinliang Chen, Baofeng Zhu, Dongmei Zhang, Jianrong Chen
Summary: BRG1 plays a key role in apoptosis and oxidative damage, but its role in the pathophysiology of ischemic stroke is unclear. We found that BRG1 expression was increased during cerebral ischemia and reperfusion, particularly in activated microglia. Modulating BRG1 expression levels significantly affected microglial activation and the expression of antioxidant and pro-oxidant proteins after ischemic stroke. Our findings suggest that BRG1 protects against brain ischemia/reperfusion injury by reducing oxidative damage through the KEAP1-NRF2/HO-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lian Liu, Quan Cao, Wenwei Gao, Bing-yu Li, Cheng Zeng, Zhongyuan Xia, Bo Zhao
Summary: Melatonin treatment can protect against CIR-induced brain damage in diabetic mice, possibly through enhancing autophagy mediated by the SIRT1-BMAL1 pathway.
Article
Plant Sciences
Shouchao Xu, Ping Huang, Jiehong Yang, Haixia Du, Haitong Wan, Yu He
Summary: In this study, it was found that Calysoin (CA) attenuated cerebral ischemia-reperfusion injury (CIRI) by inhibiting excessive autophagy via the STAT3/FOXO3a signaling pathway in rats and PC12 cells. The experimental results showed that CA improved CIRI by reducing cerebral infarct volume and neurological deficits. CA protected against inflammation, oxidative stress, and cell apoptosis, and modulated autophagy-related gene expression.
Article
Pharmacology & Pharmacy
Yanling Li, Jing Gao, Chuntian Liu, Ning Bu, Shuqin Zhan, Haiqin Wu, Ru Zhang, Hong Sun, Hong Fan
Summary: This study found that USP22 expression is increased in response to ischemic brain damage, but its biological role and mechanism remain unclear. By intravenously injecting USP22 shRNA into the mouse brain and constructing a middle cerebral artery occlusion/reperfusion (MCAO/R) mouse model, the researchers evaluated the effects of USP22 on infarct volume, neurobehavioral deficit, cell apoptosis, oxidative stress, and autophagy. They found that USP22 exerts neuroprotective effects in cerebral ischemia/reperfusion injury by downregulating PTEN and activating the mTOR/TFEB pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Neurosciences
Yi Zhong, Bo Yin, Yingze Ye, Omar Y. A. T. Dekhel, Xiaoxing Xiong, Zhihong Jian, Lijuan Gu
Summary: The JAK2/STAT3 signaling pathway plays a crucial role in ischemic stroke by regulating inflammatory response, apoptosis, oxidative stress, and angiogenesis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Environmental Sciences
Miao Chen, Limin Fan, Guoping Wu, Hairong Wang, Shuo Gu
Summary: This study investigated the role of EZH2 and H3K27me3 in cerebral ischemia-reperfusion injury using rat models and primary cortical neuron models. The expression levels of EZH2 and H3K27me3 were upregulated under oxygen-glucose deprivation conditions and further enhanced by GSK-J4, but reduced by EPZ-6438 and AKT inhibitor. Inhibition of EZH2 or AKT effectively counteracted cell apoptosis and reduced infarct size in vivo. These findings suggest that EZH2 inhibition protects against ischemic brain injury through modulation of the H3K27me3/PI3K/AKT/mTOR signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Minghua Xian, Jiale Cai, Kening Zheng, Qu Liu, Yali Liu, Huiting Lin, Shengwang Liang, Shumei Wang
Summary: AE has a protective effect against cerebral ischemia-reperfusion injury, possibly through the PI3K/AKT/mTOR and NF-kappa B signaling pathways.
Article
Plant Sciences
Meijuan Yin, Zhenyi Liu, Jing Wang, Weijuan Gao
Summary: The aim of this study was to investigate the molecular mechanism of Buyang Huanwu Decoction (BYHWD) in attenuating cerebral ischemia-reperfusion (I/R) oxidative damage by activating the PKC epsilon/Nrf2/HO-1 pathway. The results showed that BYHWD improved neural function, reduced neuronal damage, inhibited ROS production, decreased MDA and 8-OHdG levels, increased SOD and GSH-PX activity, and restored mitochondrial membrane potential. BYHWD activated the expression of Nrf2 and PKC epsilon, promoted Nrf2 translocation, and enhanced HO-1 expression. Therefore, BYHWD attenuates oxidative damage and reduces brain I/R injury by activating the PKC epsilon/Nrf2/HO-1 pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Biao Yang, Yaqiong Li, Yanmei Ma, Xiaopeng Zhang, Lan Yang, Xilin Shen, Jianzhong Zhang, Li Jing
Summary: The study found that selenium can inhibit autophagy by regulating the PI3K/AKT/mTOR signaling pathway, significantly preventing BBB damage following cerebral I/R injury in hyperglycemic conditions.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Plant Sciences
Hanyi Hua, Wenyi Zhang, Jiaying Li, Jiayi Li, Chang Liu, Yahui Guo, Yuliang Cheng, Fuwei Pi, Yunfei Xie, Weirong Yao, Yanqin Gao, He Qian
Summary: The study aimed to investigate the neuroprotective effect of the aqueous extract of turnip on cerebral ischemia/reperfusion. The results showed that the extract can reduce cerebral infarct volume, improve behavioral deficits in MCAO/R mice, and exhibit antioxidant effects in HT-22 cells, while enhancing cell survival by activating the PI3K/Akt/mTOR pathway in OGD/R-injured cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Hongwen Lan, Qiang Zheng, Kan Wang, Chenghao Li, Tixiusi Xiong, Jiawei Shi, Nianguo Dong
Summary: With the shortage of organs becoming more severe, improvements in organ protection are needed to meet transplantation demands. This study found that cinnamaldehyde has a protective effect against ischemia-reperfusion injury in donor hearts exposed to prolonged cold ischemia, improving cardiac function and reducing inflammation, oxidative stress, and myocardial apoptosis. Further investigations showed that the cardioprotective effects of cinnamaldehyde were mediated through the activation of the PI3K/AKT/mTOR pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Integrative & Complementary Medicine
Qing Han, Feng Wang
Summary: This study found that electroacupuncture treatment can improve the negative effects of middle cerebral artery occlusion (MCAO) on cognitive function in rats and enhance synaptic plasticity. This treatment may exert its effect by regulating the CACNA1B-CaM-CaMKII-CREB axis.
ACUPUNCTURE IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Lina Zhao, Huanming Li, Qian Gao, Jin Xu, Yongjie Zhu, Meili Zhai, Peijun Zhang, Na Shen, Yanbo Di, Jinhui Wang, Tie Chen, Meina Huang, Jinglai Sun, Chong Liu
Summary: Berberine exerts neuroprotective effects against ischemic stroke by inhibiting neuronal apoptosis induced by CIRI through downregulating the CNPY2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)