Dysregulation of Neuronal Nicotinic Acetylcholine Receptor–Cholesterol Crosstalk in Autism Spectrum Disorder

Prevalence and Age of Onset of Regression in Children with Autism Spectrum Disorder: A Systematic Review and Meta‐analytical Update

(2021) Christine Tan et al.   Autism Research

The postnatal GABA shift: A developmental perspective

(2021) Carlijn Peerboom et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

CK2α causes stemness and chemotherapy resistance in liver cancer through the Hedgehog signaling pathway

(2021) Di Wu et al.   Hepatobiliary & Pancreatic Diseases International

Screening for hypophosphatasia: does biochemistry lead the way?

(2021) Corinna Melanie Held et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

The Alleged Epidemic of Social Narcissism

(2021) Susan Mortell   Nursing Administration Quarterly

Stress-activated leukocyte 12/15-lipoxygenase metabolite enhances struggle behaviour and tocotrienols relieve stress-induced behaviour alteration

(2021) Mototada Shichiri et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Neurochemistry of Autism

(2020) Rosa Marotta et al.   Brain Sciences

Membrane cholesterol dependence of cannabinoid modulation of glycine receptor

(2020) Lei Yao et al.   FASEB JOURNAL

Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission

(2020) Miloslav Korinek et al.   Scientific Reports

Effects of Higher Serum Lipid Levels on the Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis

(2020) Zheng Jiang et al.   Frontiers in Neurology

Lovastatin Differentially Regulates α7 and α4 Neuronal Nicotinic Acetylcholine Receptor Levels in Rat Hippocampal Neurons

(2020) Virginia Borroni et al.   MOLECULES

Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism

(2020) Victoria L. Castro et al.   GENESIS

Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome

(2019) Marco Segatto et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antibody‐induced crosslinking and cholesterol‐sensitive, anomalous diffusion of nicotinic acetylcholine receptors

(2019) Alejo Mosqueira et al.   JOURNAL OF NEUROCHEMISTRY

Perinatal compromise contributes to programming of GABAergic and glutamatergic systems leading to long‐term effects on offspring behaviour

(2019) Julia C. Shaw et al.   JOURNAL OF NEUROENDOCRINOLOGY

Membrane cholesterol depletion in cortical neurons highlights altered NMDA receptor functionality in a mouse model of amyotrophic lateral sclerosis

(2018) Alessia Antonini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The fetus at the tipping point: modifying the outcome of fetal asphyxia

(2018) Simerdeep K. Dhillon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice

(2018) Qionger He et al.   MOLECULAR PSYCHIATRY

Altered Brain Cholesterol/Isoprenoid Metabolism in a Rat Model of Autism Spectrum Disorders

(2018) Veronica Cartocci et al.   NEUROSCIENCE

Postnatal Changes in K + /Cl − Cotransporter-2 Expression in the Forebrain of Mice Bearing a Mutant Nicotinic Subunit Linked to Sleep-Related Epilepsy

(2018) Alida Amadeo et al.   NEUROSCIENCE

Chloride transporters and GABA polarity in developmental, neurological and psychiatric conditions

(2018) Joran T. Schulte et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Current Enlightenment About Etiology and Pharmacological Treatment of Autism Spectrum Disorder

(2018) Nermin Eissa et al.   Frontiers in Neuroscience

Autism spectrum disorder

(2018) Catherine Lord et al.   LANCET

Neurosteroid replacement therapy using the allopregnanolone-analogue ganaxolone following preterm birth in male guinea pigs

(2018) Julia C. Shaw et al.   PEDIATRIC RESEARCH

Cholesterol modulates acetylcholine receptor diffusion by tuning confinement sojourns and nanocluster stability

(2018) Alejo Mosqueira et al.   Scientific Reports

Birth and Neonatal Transition in the Guinea Pig: Experimental Approaches to Prevent Preterm Birth and Protect the Premature Fetus

(2018) Jonathan J. Hirst et al.   Frontiers in Physiology

Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments

(2017) Erdinc Sezgin et al.   FEBS Journal

Cholinergic circuits in cognitive flexibility

(2017) Vania F. Prado et al.   NEUROSCIENCE

New insights of altered lipid profile in Fragile X Syndrome

(2017) Artuela Çaku et al.   PLoS One

The Cholinergic System Modulates Memory and Hippocampal Plasticity via Its Interactions with Non-Neuronal Cells

(2017) Sara V. Maurer et al.   Frontiers in Immunology

Cerebellar anatomical alterations and attention to eyes in autism

(2017) Charles Laidi et al.   Scientific Reports

Statins and the Brain: More than Lipid Lowering Agents?

(2017) Anna Fracassi et al.   Current Neuropharmacology

The lipid habitats of neurotransmitter receptors in brain

(2016) María Virginia Borroni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

(2016) Lydie Boussicault et al.   BRAIN

The α4β2 nicotinic acetylcholine receptor modulates autism-like behavioral and motor abnormalities in pentylenetetrazol-kindled mice

(2016) Kenshi Takechi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modulation of the Isoprenoid/Cholesterol Biosynthetic Pathway During Neuronal Differentiation In Vitro

(2016) Veronica Cartocci et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Heterogeneous Inhibition in Macroscopic Current Responses of Four Nicotinic Acetylcholine Receptor Subtypes by Cholesterol Enrichment

(2016) Carlos A. Báez-Pagán et al.   JOURNAL OF MEMBRANE BIOLOGY

Wnt signaling networks in autism spectrum disorder and intellectual disability

(2016) Vickie Kwan et al.   Journal of Neurodevelopmental Disorders

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

(2016) C. Lane-Donovan et al.   JOURNAL OF NEUROSCIENCE

Integration of inhibitory and excitatory effects of α7 nicotinic acetylcholine receptor activation in the prelimbic cortex regulates network activity and plasticity

(2016) Matthew Udakis et al.   NEUROPHARMACOLOGY

Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome

(2016) Abhishek Banerjee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 15q13.3 deletion syndrome: Deficient α7-containing nicotinic acetylcholine receptor-mediated neurotransmission in the pathogenesis of neurodevelopmental disorders

(2016) Stephen I. Deutsch et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Genetic Syndromes, Maternal Diseases and Antenatal Factors Associated with Autism Spectrum Disorders (ASD)

(2016) Asher Ornoy et al.   Frontiers in Neuroscience

A mirror code for protein-cholesterol interactions in the two leaflets of biological membranes

(2016) Jacques Fantini et al.   Scientific Reports

The impairment of cholesterol metabolism in Huntington disease

(2015) Valerio Leoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The interaction between maternal immune activation and alpha 7 nicotinic acetylcholine receptor in regulating behaviors in the offspring

(2015) Wei-Li Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Cholesterol modulates open probability and desensitization of NMDA receptors

(2015) Miloslav Korinek et al.   JOURNAL OF PHYSIOLOGY-LONDON

Nicotine recruits glutamate receptors to postsynaptic sites

(2015) Jing-jing Duan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rett Syndrome: Reaching for Clinical Trials

(2015) Lucas Pozzo-Miller et al.   Neurotherapeutics

Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system

(2015) Li Wang et al.   PSYCHOPHARMACOLOGY

Cholesterol metabolites exported from human brain

(2015) Luigi Iuliano et al.   STEROIDS

Nicotinic ACh receptors as therapeutic targets in CNS disorders

(2015) Kelly T. Dineley et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Dendritic spine density of prefrontal layer 6 pyramidal neurons in relation to apical dendrite sculpting by nicotinic acetylcholine receptors

(2015) Lily Kang et al.   Frontiers in Cellular Neuroscience

Preterm birth affects GABAA receptor subunit mRNA levels during the foetal-to-neonatal transition in guinea pigs

(2015) J. C. Shaw et al.   Journal of Developmental Origins of Health and Disease

Cholesterol levels in Fragile X syndrome

(2014) Elizabeth Berry-Kravis et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

A Predicted Binding Site for Cholesterol on the GABAA Receptor

(2014) Jérôme Hénin et al.   BIOPHYSICAL JOURNAL

Cholesterol Homeostasis Failure in the Brain: Implications for Synaptic Dysfunction and Cognitive Decline

(2014) Marco Segatto et al.   CURRENT MEDICINAL CHEMISTRY

Metalloproteinase inhibition prevents inhibitory synapse reorganization and seizure genesis

(2014) Emily Pollock et al.   NEUROBIOLOGY OF DISEASE

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

(2014) Wei-Qun Fang et al.   Cell Reports

Lipid rafts: a signaling platform linking cholesterol metabolism to synaptic deficits in autism spectrum disorders

(2014) Hansen Wang   Frontiers in Behavioral Neuroscience

Biogenesis, trafficking and up-regulation of nicotinic ACh receptors

(2013) Sara Francesca Colombo et al.   BIOCHEMICAL PHARMACOLOGY

An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders

(2013) Steven Andrew Baker et al.   CELL

Nicotine induces dendritic spine remodeling in cultured hippocampal neurons

(2013) Akira Oda et al.   JOURNAL OF NEUROCHEMISTRY

Activation of α7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses

(2013) Xulong Wang et al.   JOURNAL OF NEUROCHEMISTRY

α7-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability

(2013) Volodymyr I. Pidoplichko et al.   JOURNAL OF NEUROPHYSIOLOGY

Galantamine efficacy and tolerability as an augmentative therapy in autistic children: A randomized, double-blind, placebo-controlled trial

(2013) Ali Ghaleiha et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Autism

(2013) Meng-Chuan Lai et al.   LANCET

Cholesterol metabolism and Rett syndrome pathogenesis

(2013) Gabor Nagy et al.   NATURE GENETICS

A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome

(2013) Christie M Buchovecky et al.   NATURE GENETICS

Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor

(2013) Matthew J Lyst et al.   NATURE NEUROSCIENCE

Cortical synaptic NMDA receptor deficits in α7 nicotinic acetylcholine receptor gene deletion models: Implications for neuropsychiatric diseases

(2013) Hong Lin et al.   NEUROBIOLOGY OF DISEASE

Changes in Neuroactive Steroid Concentrations After Preterm Delivery in the Guinea Pig

(2013) Meredith A. Kelleher et al.   Reproductive Sciences

A meta-analysis of cardio-metabolic abnormalities in drug naïve, first-episode and multi-episode patients with schizophrenia versus general population controls

(2013) Davy Vancampfort et al.   World Psychiatry

A novel DNA-binding feature of MeCP2 contributes to Rett syndrome

(2013) Xin Xu et al.   Frontiers in Cellular Neuroscience

The Dynamics of Autism Spectrum Disorders: How Neurotoxic Compounds and Neurotransmitters Interact

(2013) Ilona Quaak et al.   International Journal of Environmental Research and Public Health

Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system

(2012) M. Segatto et al.   Acta Physiologica

Treatment of Smith-Lemli-Opitz syndrome and other sterol disorders

(2012) Melissa D. Svoboda et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

24S-hydroxycholesterol in plasma: A marker of cholesterol turnover in neurodegenerative diseases

(2012) Valerio Leoni et al.   BIOCHIMIE

Induction of Dendritic Spines by  2-Containing Nicotinic Receptors

(2012) A. F. Lozada et al.   JOURNAL OF NEUROSCIENCE

Glutamatergic Synapse Formation is Promoted by  7-Containing Nicotinic Acetylcholine Receptors

(2012) A. F. Lozada et al.   JOURNAL OF NEUROSCIENCE

Cholesterol, GM1, and Autism

(2012) Cara-Lynne Schengrund et al.   NEUROCHEMICAL RESEARCH

Effects of sex and chronic neonatal nicotine treatment on Na2+/K+/Cl− co-transporter 1, K+/Cl− co-transporter 2, brain-derived neurotrophic factor, NMDA receptor subunit 2A and NMDA receptor subunit 2B mRNA expression in the postnatal rat hippocampus

(2012) J.C. Damborsky et al.   NEUROSCIENCE

Dendritic spine alterations in the hippocampus and parietal cortex of alpha7 nicotinic acetylcholine receptor knockout mice

(2012) B.J. Morley et al.   NEUROSCIENCE

Chaperoning α7 neuronal nicotinic acetylcholine receptors

(2011) Ana S. Vallés et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Nicotinic α5 Subunits Drive Developmental Changes in the Activation and Morphology of Prefrontal Cortex Layer VI Neurons

(2011) Craig D.C. Bailey et al.   BIOLOGICAL PSYCHIATRY

15q11.2–13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain

(2011) Dag H. Yasui et al.   HUMAN MOLECULAR GENETICS

Cholesterol Modulates the Rate and Mechanism of Acetylcholine Receptor Internalization

(2011) Virginia Borroni et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nerve Terminal Nicotinic Acetylcholine Receptors Initiate Quantal GABA Release from Perisomatic Interneurons by Activating Axonal T-Type (Cav3) Ca2+ Channels and Ca2+ Release from Stores

(2011) A.-H. Tang et al.   JOURNAL OF NEUROSCIENCE

Timing-Dependent Septal Cholinergic Induction of Dynamic Hippocampal Synaptic Plasticity

(2011) Zhenglin Gu et al.   NEURON

Cholinergic modulation of cognition: Insights from human pharmacological functional neuroimaging

(2011) Paul Bentley et al.   PROGRESS IN NEUROBIOLOGY

Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor

(2011) Carlos J. Baier et al.   Scientific Reports

Alterations of GABAergic Signaling in Autism Spectrum Disorders

(2011) Rocco Pizzarelli et al.   NEURAL PLASTICITY

Early Life Programming and Neurodevelopmental Disorders

(2010) Tracy L. Bale et al.   BIOLOGICAL PSYCHIATRY

Cholesterol reduction impairs exocytosis of synaptic vesicles

(2010) A. Linetti et al.   JOURNAL OF CELL SCIENCE

Age- and sex-related differences in extra-hepatic low-density lipoprotein receptor

(2010) Marco Segatto et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Endogenous Signaling through  7-Containing Nicotinic Receptors Promotes Maturation and Integration of Adult-Born Neurons in the Hippocampus

(2010) N. R. Campbell et al.   JOURNAL OF NEUROSCIENCE

Alterations in lipid profile of autistic boys: a case control study

(2010) Eun-Kyung Kim et al.   NUTRITION RESEARCH

Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors

(2010) I. Ballesteros-Yanez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingolipid/cholesterol regulation of neurotransmitter receptor conformation and function

(2009) Jacques Fantini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol modulation of nicotinic acetylcholine receptor surface mobility

(2009) Carlos J. Baier et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

Association between APOE polymorphisms and predisposition for autism

(2009) Carina Tatiana Giunco et al.   PSYCHIATRIC GENETICS

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Dissociated Gender-Specific Effects of Recurrent Seizures on GABA Signaling in CA1 Pyramidal Neurons: Role of GABAA Receptors

(2008) A. S. Galanopoulou   JOURNAL OF NEUROSCIENCE

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Leaky synapses: Regulation of spontaneous neurotransmission in central synapses

(2008) C.R. Wasser et al.   NEUROSCIENCE

Birth Weight and Gestational Age Characteristics of Children With Autism, Including a Comparison With Other Developmental Disabilities

(2008) D. Schendel et al.   PEDIATRICS

Ceramides modulate cell-surface acetylcholine receptor levels

(2007) C.E. Gallegos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES