EP3 Receptor Deficiency Improves Vascular Remodeling and Cognitive Impairment in Cerebral Small Vessel Disease

A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action

(2020) Roger G. Biringer   Journal of Cell Communication and Signaling

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease

(2019) Sau May Wong et al.   NEUROLOGY

Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices

(2019) Michael Schou Jensen et al.   Acta Physiologica

CNS small vessel disease

(2019) Rocco J. Cannistraro et al.   NEUROLOGY

Inflammation and cerebral small vessel disease: A systematic review

(2019) Audrey Low et al.   AGEING RESEARCH REVIEWS

Central EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation

(2019) Liang Xiao et al.   HYPERTENSION

PGE2-EP3 signaling exacerbates hippocampus-dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity-related proteins in aged mice

(2018) Jing-Yu Xiao et al.   CNS Neuroscience & Therapeutics

Cerebral small vessel disease: from a focal to a global perspective

(2018) Annemieke ter Telgte et al.   Nature Reviews Neurology

Prostaglandin-cytokine crosstalk in chronic inflammation

(2018) Chengcan Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cerebral Venous Collagen Remodeling in a Modified White Matter Lesions Animal Model

(2017) Jing Lin et al.   NEUROSCIENCE

Increased role of E prostanoid receptor-3 in prostacyclin-evoked contractile activity of spontaneously hypertensive rat mesenteric resistance arteries

(2017) Bin Liu et al.   Scientific Reports

Vascular Smooth Muscle-Specific EP4 Receptor Deletion in Mice Exacerbates Angiotensin II-Induced Renal Injury

(2016) Jean-Francois Thibodeau et al.   ANTIOXIDANTS & REDOX SIGNALING

Optimization of amide-based EP3 receptor antagonists

(2016) Esther C.Y. Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of COX-2-derived PGE2on vascular stiffness and function in hypertension

(2016) M S Avendaño et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prostaglandin E2inhibits collagen synthesis in dermal fibroblasts and prevents hypertrophic scar formationin vivo

(2016) Jingling Zhao et al.   EXPERIMENTAL DERMATOLOGY

A Cyclooxygenase-2 Inhibitor Reduces Vascular Wall Thickness and Ameliorates Cognitive Impairment in a Cerebral Small Vessel Diseases Rat Model

(2015) Jie Tang et al.   Current Alzheimer Research

EP3 receptor deficiency attenuates pulmonary hypertension through suppression of Rho/TGF-β1 signaling

(2015) Ankang Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Spontaneous white matter lesion in brain of stroke-prone renovascular hypertensive rats: a study from MRI, pathology and behavior

(2015) Yuhua Fan et al.   METABOLIC BRAIN DISEASE

Cerebral small-resistance artery structure and cerebral blood flow in normotensive subjects and hypertensive patients

(2014) Carolina De Ciuceis et al.   NEURORADIOLOGY

PTGER1 Deletion Attenuates Renal Injury in Diabetic Mouse Models

(2013) Jean-François Thibodeau et al.   AMERICAN JOURNAL OF PATHOLOGY

Blocking the EP3 receptor for PGE2 with DG-041 decreases thrombosis without impairing haemostatic competence

(2013) Peggy Tilly et al.   CARDIOVASCULAR RESEARCH

Cyclooxygenase-2–Derived Prostaglandin E 2 Promotes Injury-Induced Vascular Neointimal Hyperplasia Through the E-prostanoid 3 Receptor

(2013) Jian Zhang et al.   CIRCULATION RESEARCH

Cyclooxygenase-2 Genetic Polymorphism and Stroke Subtypes in Chinese

(2013) Guo-zhong Chen et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Stroke-prone renovascular hypertensive rat as an animal model for stroke studies: From artery to brain

(2013) Song-Jie Liao et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial

(2013)   LANCET

Hypertension and longitudinal changes in cerebral blood flow: The SMART-MR study

(2012) Majon Muller et al.   ANNALS OF NEUROLOGY

Inactivation of the E-Prostanoid 3 Receptor Attenuates the Angiotensin II Pressor Response via Decreasing Arterial Contractility

(2012) Lihong Chen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Transforming growth factor-beta1 induces microvascular abnormalities through a down-modulation of neural cell adhesion molecule in human hepatocellular carcinoma

(2012) Piera Balzarini et al.   LABORATORY INVESTIGATION

Effects on platelet function of an EP3 receptor antagonist used alone and in combination with a P2Y12antagonist bothin-vitroandex-vivoin human volunteers

(2012) S.C. Fox et al.   PLATELETS

Angiotensin II and the vascular phenotype in hypertension

(2011) Carmine Savoia et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Inhibition of prostaglandin E2 EP3 receptors improves stroke injury via anti-inflammatory and anti-apoptotic mechanisms

(2011) Yuri Ikeda-Matsuo et al.   JOURNAL OF NEUROIMMUNOLOGY

Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats

(2011) E. L. Bailey et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Impact of Microsomal Prostaglandin E Synthase 1 on Blood Pressure Is Determined by Genetic Background

(2010) Carie S. Facemire et al.   HYPERTENSION

Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies

(2010) Koh-ichi Yuhki et al.   PHARMACOLOGY & THERAPEUTICS

Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint

(2009) Elena MV de Cavanagh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Reduced acute brain injury in PGE2 EP3 receptor-deficient mice after cerebral ischemia

(2009) Sofiyan Saleem et al.   JOURNAL OF NEUROIMMUNOLOGY

Total Cerebral Blood Flow in Relation to Cognitive Function: The Rotterdam Scan Study

(2008) Mariëlle MF Poels et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM