Activation of the prostaglandin E 2 EP 2 receptor attenuates renal fibrosis in unilateral ureteral obstructed mice and human kidney slices

The protective effect of the EP2 receptor on TGF-β1 induced podocyte injury via the PI3K / Akt signaling pathway

(2018) Jing Liu et al.   PLoS One

Role of the prostaglandin E2 receptor agonists in TGF- 1-induced mesangial cell damage

(2016) P.-p. Xi et al.   BIOSCIENCE REPORTS

Precision-cut human kidney slices as a model to elucidate the process of renal fibrosis

(2016) Elisabeth G.D. Stribos et al.   Translational Research

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Therapeutic targets for treating fibrotic kidney diseases

(2015) So-Young Lee et al.   Translational Research

Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice

(2015) Chuanxu Yang et al.   Theranostics

Prostaglandin E2 modifies SMAD2 and promotes SMAD2–SMAD4 complex formation

(2014) Chen Yang et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

PTGER1 Deletion Attenuates Renal Injury in Diabetic Mouse Models

(2013) Jean-François Thibodeau et al.   AMERICAN JOURNAL OF PATHOLOGY

EMT–MET in renal disease: Should we curb our enthusiasm?

(2013) Pierre Galichon et al.   CANCER LETTERS

Epithelial phenotypic changes are associated with a tubular active fibrogenic process in human renal grafts

(2013) Yi-Chun Xu-Dubois et al.   HUMAN PATHOLOGY

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

The intrinsic prostaglandin E2–EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice

(2012) Naoki Nakagawa et al.   KIDNEY INTERNATIONAL

Fibroblast-specific expression of AC6 enhances β-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis

(2010) Xiaoqiu Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

PGE2 receptor EP2 mediates the antagonistic effect of COX-2 on TGF-β signaling during mammary tumorigenesis

(2009) Maozhen Tian et al.   FASEB JOURNAL

Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-  through a PGE2-dependent mechanisms

(2008) J. R. Neil et al.   CARCINOGENESIS

Transforming Growth Factor-β1 (TGFβ1) Stimulates Connective Tissue Growth Factor (CCN2/CTGF) Expression in Human Gingival Fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent Mechanism

(2008) Samuel A. Black et al.   JOURNAL OF BIOLOGICAL CHEMISTRY