Aquaporin-4 and Cognitive Disorders

Circulating AQP4 Levels in Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage

(2021) Paula Marazuela et al.   Journal of Clinical Medicine

Microglia use TAM receptors to detect and engulf amyloid β plaques

(2021) Youtong Huang et al.   NATURE IMMUNOLOGY

Is Cerebral Amyloid-β Deposition Related to Post-stroke Cognitive Impairment?

(2021) Fubing Ouyang et al.   Translational Stroke Research

Multi‐cohort profiling reveals elevated CSF levels of brain‐enriched proteins in Alzheimer’s disease

(2021) Sofia Bergström et al.   Annals of Clinical and Translational Neurology

Regulation of AQP4 in the Central Nervous System

(2020) Arno Vandebroek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hyperthyroidism and Dementia

(2020) David S. Cooper et al.   THYROID

Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus

(2020) Benjamin C. Reeves et al.   TRENDS IN MOLECULAR MEDICINE

Accumulation of Astrocytic Aquaporin 4 and Aquaporin 1 in Prion Protein Plaques

(2020) Shoko Sadashima et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

The Brain’s Glymphatic System: Current Controversies

(2020) Humberto Mestre et al.   TRENDS IN NEUROSCIENCES

Haplotype of the astrocytic water channel AQP4 is associated with slow wave energy regulation in human NREM sleep

(2020) Sara Marie Ulv Larsen et al.   PLOS BIOLOGY

Impaired glymphatic function and clearance of tau in an Alzheimer’s disease model

(2020) Ian F Harrison et al.   BRAIN

Inhibition of Aquaporin 4 Decreases Amyloid Aβ40 Drainage Around Cerebral Vessels

(2020) Gabriela-Camelia Rosu et al.   MOLECULAR NEUROBIOLOGY

Relationship Between Hematoma Expansion Induced by Hypertension and Hyperglycemia and Blood–brain Barrier Disruption in Mice and Its Possible Mechanism: Role of Aquaporin-4 and Connexin43

(2020) Heling Chu et al.   Neuroscience Bulletin

Cognitive Impairment Evaluation and Management

(2020) Lauren McCollum et al.   MEDICAL CLINICS OF NORTH AMERICA

HUCBC Treatment Improves Cognitive Outcome in Rats With Vascular Dementia

(2020) Poornima Venkat et al.   Frontiers in Aging Neuroscience

Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease

(2019) Simone Mader et al.   Cells

Aquaporin‐4 deficiency reduces TGF‐β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease

(2019) Xue Xue et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Aquaporin 4: A key player in Parkinson's disease

(2019) Omid Reza Tamtaji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow

(2019) Benjamin A. Plog et al.   JOURNAL OF NEUROSURGERY

Parkinson's Disease Dementia and Lewy Body Disease

(2019) Mine Sezgin et al.   SEMINARS IN NEUROLOGY

Evidence of Aquaporin 4 Regulation by Thyroid Hormone During Mouse Brain Development and in Cultured Human Glioblastoma Multiforme Cells

(2019) Lucas E. S. Costa et al.   Frontiers in Neuroscience

Aquaporin-4 reduces neuropathology in a mouse model of Alzheimer’s disease by remodeling peri-plaque astrocyte structure

(2019) Alex J. Smith et al.   Acta Neuropathologica Communications

Cerebrospinal Fluid Level of Aquaporin4: A New Window on Glymphatic System Involvement in Neurodegenerative Disease?

(2019) Andrea Arighi et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis

(2019) Peter Dongmin Sohn et al.   NEURON

A Novel Model of Mixed Vascular Dementia Incorporating Hypertension in a Rat Model of Alzheimer’s Disease

(2019) Paul Denver et al.   Frontiers in Physiology

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants

(2019) Li-Chun Lin et al.   Acta Neuropathologica Communications

Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients

(2019) Md Mahdi Hasan-Olive et al.   Fluids and Barriers of the CNS

Are dementia with Lewy bodies and Parkinson’s disease dementia the same disease?

(2018) Kurt A. Jellinger et al.   BMC Medicine

Delayed clearance of cerebrospinal fluid tracer from entorhinal cortex in idiopathic normal pressure hydrocephalus: A glymphatic magnetic resonance imaging study

(2018) Per K Eide et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

(2018) Stephanie R. Rainey-Smith et al.   Translational Psychiatry

Role of microRNA-126 in vascular cognitive impairment in mice

(2018) Peng Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

(2018) Matthew J. Simon et al.   Scientific Reports

Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus

(2018) Md Mahdi Hasan-Olive et al.   GLIA

Pathogenesis of idiopathic Normal Pressure Hydrocephalus: A review of knowledge

(2018) Konstantin Bräutigam et al.   JOURNAL OF CLINICAL NEUROSCIENCE

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Dementia with Lewy bodies and Parkinson’s disease-dementia: current concepts and controversies

(2017) Kurt A. Jellinger   JOURNAL OF NEURAL TRANSMISSION

Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion

(2017) Yoshiki Hase et al.   Journal of Neuroinflammation

White matter damage and glymphatic dysfunction in a model of vascular dementia in rats with no prior vascular pathologies

(2017) Poornima Venkat et al.   NEUROBIOLOGY OF AGING

Astrogliosis and impaired aquaporin-4 and dystrophin systems in idiopathic normal pressure hydrocephalus

(2017) P. K. Eide et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)

(2017) Tiffany L. Sudduth et al.   NEUROSCIENCE

Continuous theta burst stimulation facilitates the clearance efficiency of the glymphatic pathway in a mouse model of sleep deprivation

(2017) Dong-xu Liu et al.   NEUROSCIENCE LETTERS

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Aquaporin-4 and Alzheimer’s Disease

(2016) Canhong Yang et al.   JOURNAL OF ALZHEIMERS DISEASE

Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation

(2015) Prabodh Sadana et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Vascular dementia

(2015) John T O'Brien et al.   LANCET

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Regulation and Function of AQP4 in the Central Nervous System

(2015) Mette Assentoft et al.   NEUROCHEMICAL RESEARCH

Sleep and Alzheimer's disease

(2015) Laure Peter-Derex et al.   SLEEP MEDICINE REVIEWS

Aβ Clearance, “hub” of Multiple Deficiencies Leading to Alzheimer Disease

(2015) Pasquale Gallina et al.   Frontiers in Aging Neuroscience

The overlap between vascular disease and Alzheimer’s disease - lessons from pathology

(2014) Johannes Attems et al.   BMC Medicine

The role of aquaporin 4 in apoptosis after intracerebral hemorrhage

(2014) Heling Chu et al.   Journal of Neuroinflammation

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

(2014) Jeffrey J. Iliff et al.   JOURNAL OF NEUROSCIENCE

Erythropoietin protects against hemorrhagic blood–brain barrier disruption through the effects of aquaporin-4

(2014) Heling Chu et al.   LABORATORY INVESTIGATION

GLT-1 transporter: An effective pharmacological target for various neurological disorders

(2014) Neha Soni et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Cerebrospinal Fluid Biomarker and Brain Biopsy Findings in Idiopathic Normal Pressure Hydrocephalus

(2014) Okko T. Pyykkö et al.   PLoS One

Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?

(2013) Zaira Esposito et al.   CNS Neuroscience & Therapeutics

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

Characteristics of Aquaporin Expression Surrounding Senile Plaques and Cerebral Amyloid Angiopathy in Alzheimer Disease

(2012) Akihiko Hoshi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Aquaporin-4 mediates astrocyte response to β-amyloid

(2012) Wei Yang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease

(2011) Sergio T. Ferreira et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Aquaporin Expression in the Brains of Patients With or Without Cerebral Amyloid Angiopathy

(2010) Parham Moftakhar et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid-  Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

(2009) J.-E. Kang et al.   SCIENCE