Aquaporin-4 Water Channel in the Brain and Its Implication for Health and Disease

The role of aquaporin-4 in synaptic plasticity, memory and disease

(2018) Jacqueline A. Hubbard et al.   BRAIN RESEARCH BULLETIN

The “glymphatic” mechanism for solute clearance in Alzheimer’s disease: game changer or unproven speculation?

(2018) Alex J. Smith et al.   FASEB JOURNAL

Recombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica

(2018) Lukmanee Tradtrantip et al.   NEUROPHARMACOLOGY

Dissociation of blood-brain barrier disruption and disease manifestation in an aquaporin-4-deficient mouse model of amyotrophic lateral sclerosis

(2018) Saori Watanabe-Matsumoto et al.   NEUROSCIENCE RESEARCH

β-Amyloid accumulation in the human brain after one night of sleep deprivation

(2018) Ehsan Shokri-Kojori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

(2018) Stephanie R. Rainey-Smith et al.   Translational Psychiatry

Aquaporin-4 Autoantibodies From Neuromyelitis Optica Spectrum Disorder Patients Induce Complement-Independent Immunopathologies in Mice

(2018) Leung-Wah Yick et al.   Frontiers in Immunology

Analysis of chromatin accessibility uncovers TEAD1 as a regulator of migration in human glioblastoma

(2018) Jessica Tome-Garcia et al.   Nature Communications

The glymphatic pathway in neurological disorders

(2018) Martin Kaag Rasmussen et al.   LANCET NEUROLOGY

Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways

(2017) Ionica Pirici et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

Aquaporin-4 serostatus does not predict response to immunotherapy in neuromyelitis optica spectrum disorders

(2017) Maureen A Mealy et al.   Multiple Sclerosis Journal

Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice

(2017) Agnete Prydz et al.   NEUROSCIENCE

Glucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica

(2017) Fumitaka Shimizu et al.   Science Translational Medicine

Perivascular AQP4 dysregulation in the hippocampal CA1 area after traumatic brain injury is alleviated by adenosine A2A receptor inactivation

(2017) Zi-Ai Zhao et al.   Scientific Reports

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

(2017) Douglas M. Zeppenfeld et al.   JAMA Neurology

Aquaporin-4 serostatus does not predict response to immunotherapy in neuromyelitis optica spectrum disorders

(2017) Maureen A Mealy et al.   Multiple Sclerosis Journal

Expression of Aquaporin 1 and Aquaporin 4 in the Temporal Neocortex of Patients with Parkinson's Disease

(2016) Akihiko Hoshi et al.   BRAIN PATHOLOGY

The Indispensable Roles of Microglia and Astrocytes during Brain Development

(2016) Kitty Reemst et al.   Frontiers in Human Neuroscience

Multicentre comparison of a diagnostic assay: aquaporin-4 antibodies in neuromyelitis optica

(2016) Patrick Waters et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Hydrocephalus: the role of cerebral aquaporin-4 channels and computational modeling considerations of cerebrospinal fluid

(2016) Bhargav Desai et al.   Neurosurgical Focus

Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses

(2015) Ingo Kleiter et al.   ANNALS OF NEUROLOGY

Long non‐coding RNAs in corticogenesis: deciphering the non‐coding code of the brain

(2015) Julieta Aprea et al.   EMBO JOURNAL

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

The Glymphatic System: A Beginner’s Guide

(2015) Nadia Aalling Jessen et al.   NEUROCHEMICAL RESEARCH

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

(2015) Dean M. Wingerchuk et al.   NEUROLOGY

Pathogenic aquaporin-4 reactive T cells are sufficient to induce mouse model of neuromyelitis optica

(2015) Melina V Jones et al.   Acta Neuropathologica Communications

Onset of aquaporin-4 expression in the developing mouse brain

(2014) Petra Fallier-Becker et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Complement activation in patients with neuromyelitis optica

(2014) Petra Nytrova et al.   JOURNAL OF NEUROIMMUNOLOGY

Treatment of neuromyelitis optica: state-of-the-art and emerging therapies

(2014) Marios C. Papadopoulos et al.   Nature Reviews Neurology

Hydrocephalus in neuromyelitis optica

(2014) S. L. Clardy et al.   NEUROLOGY

Altered glial marker expression in autistic post-mortem prefrontal cortex and cerebellum

(2014) Catherine Edmonson et al.   Molecular Autism

Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica

(2013) Julien Ratelade et al.   ACTA NEUROPATHOLOGICA

Presence of six different lesion types suggests diverse mechanisms of tissue injury in neuromyelitis optica

(2013) Tatsuro Misu et al.   ACTA NEUROPATHOLOGICA

Biology of AQP4 and Anti-AQP4 Antibody: Therapeutic Implications for NMO

(2013) A. S. Verkman et al.   BRAIN PATHOLOGY

Glia Protein Aquaporin-4 Regulates Aversive Motivation of Spatial Memory in Morris Water Maze

(2013) Ji Zhang et al.   CNS Neuroscience & Therapeutics

Establishment of monoclonal antibodies against the extracellular domain that block binding of NMO-IgG to AQP4

(2013) Kaori Miyazaki et al.   JOURNAL OF NEUROIMMUNOLOGY

Update on the diagnosis and treatment of neuromyelitis optica: Recommendations of the Neuromyelitis Optica Study Group (NEMOS)

(2013) Corinna Trebst et al.   JOURNAL OF NEUROLOGY

Clinical and immunological follow-up of B-cell depleting therapy in CNS demyelinating diseases

(2013) Viktoria Gredler et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Aquaporin water channels in the nervous system

(2013) Marios C. Papadopoulos et al.   NATURE REVIEWS NEUROSCIENCE

Chronic ceftriaxone treatment rescues hippocampal memory deficit in AQP4 knockout mice via activation of GLT-1

(2013) Jun Yang et al.   NEUROPHARMACOLOGY

Physiological Roles of Aquaporin-4 in Brain

(2013) Erlend A. Nagelhus et al.   PHYSIOLOGICAL REVIEWS

T cell-activation in neuromyelitis optica lesions plays a role in their formation

(2013) Maria Pohl et al.   Acta Neuropathologica Communications

Coverage of Blood Vessels by Astrocytic Endfeet Is Reduced in Major Depressive Disorder

(2012) Grazyna Rajkowska et al.   BIOLOGICAL PSYCHIATRY

Super-resolution imaging of aquaporin-4 orthogonal arrays of particles in cell membranes

(2012) A. Rossi et al.   JOURNAL OF CELL SCIENCE

Aquaporin 4 and neuromyelitis optica

(2012) Marios C Papadopoulos et al.   LANCET NEUROLOGY

Serologic diagnosis of NMO: A multicenter comparison of aquaporin-4-IgG assays

(2012) P. J. Waters et al.   NEUROLOGY

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Pathogenic T cell responses against aquaporin 4

(2011) Maria Pohl et al.   ACTA NEUROPATHOLOGICA

Aquaporin-4: orthogonal array assembly, CNS functions and role in neuromyelitis optica

(2011) Alan S Verkman et al.   ACTA PHARMACOLOGICA SINICA

Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica

(2011) Lukmanee Tradtrantip et al.   ANNALS OF NEUROLOGY

Binding Affinity and Specificity of Neuromyelitis Optica Autoantibodies to Aquaporin-4 M1/M23 Isoforms and Orthogonal Arrays

(2011) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complement activating antibodies to myelin oligodendrocyte glycoprotein in neuromyelitis optica and related disorders

(2011) Simone Mader et al.   Journal of Neuroinflammation

Impairment of Select Forms of Spatial Memory and Neurotrophin-Dependent Synaptic Plasticity by Deletion of Glial Aquaporin-4

(2011) V. A. Skucas et al.   JOURNAL OF NEUROSCIENCE

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Astrocyte and Glutamate Markers in the Superficial, Deep and White Matter Layers of the Anterior Cingulate Gyrus in Schizophrenia

(2011) Pavel Katsel et al.   NEUROPSYCHOPHARMACOLOGY

Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet

(2011) N. N. Haj-Yasein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon Beta Treatment in Neuromyelitis Optica

(2010) Jacqueline Palace et al.   ARCHIVES OF NEUROLOGY

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

Temporal dynamics of anti-MOG antibodies in CNS demyelinating diseases

(2010) Franziska Di Pauli et al.   CLINICAL IMMUNOLOGY

Aquaporins and Neurodegenerative Diseases

(2010) Eleonora Foglio et al.   Current Neuropharmacology

Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen

(2010) S. Jarius et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Patterns of Antibody Binding to Aquaporin-4 Isoforms in Neuromyelitis Optica

(2010) Simone Mader et al.   PLoS One

Oligodendrocytes: biology and pathology

(2009) Monika Bradl et al.   ACTA NEUROPATHOLOGICA

Neuromyelitis optica: Pathogenicity of patient immunoglobulin in vivo

(2009) Monika Bradl et al.   ANNALS OF NEUROLOGY

Intrathecal pathogenic anti–aquaporin-4 antibodies in early neuromyelitis optica

(2009) Jeffrey L. Bennett et al.   ANNALS OF NEUROLOGY

Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies

(2009) Grazia Paola Nicchia et al.   GLIA

Live Cell Analysis of Aquaporin-4 M1/M23 Interactions and Regulated Orthogonal Array Assembly in Glial Cells

(2009) Jonathan M. Crane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aquaporin 4 correlates with apparent diffusion coefficient and hydrocephalus severity in the rat brain: A combined MRI–histological study

(2009) Thomas Tourdias et al.   NEUROIMAGE

Posterior reversible encephalopathy syndrome in neuromyelitis optica spectrum disorders

(2009) S. M. Magana et al.   NEUROLOGY

Altered blood–brain barrier integrity in adult aquaporin-4 knockout mice

(2009) Jianping Zhou et al.   NEUROREPORT

AQP4 gene deletion in mice does not alter blood–brain barrier integrity or brain morphology

(2009) S. Saadoun et al.   NEUROSCIENCE

Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance

(2009) J. D. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sporadic obstructive hydrocephalus inAqp4null mice

(2008) Xuechao Feng et al.   JOURNAL OF NEUROSCIENCE RESEARCH

NK and NKT cell dynamics after rituximab therapy for systemic lupus erythematosus and rheumatoid arthritis

(2008) Eliana A. G. Reis et al.   RHEUMATOLOGY INTERNATIONAL

Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation

(2007) Yi Fan et al.   NEUROBIOLOGY OF AGING