Review
Chemistry, Multidisciplinary
Song Shen, Jichuan Qiu, Da Huo, Younan Xia
Summary: Photothermal therapy shows great potential in killing cancer cells through hyperthermia. The efficacy is affected by various parameters, including the laser, photothermal transducers, spatial distribution of the transducers, bioeffect of the tissue (heat-sink effect, thermal conductivity), and real-time temperature monitoring.
Article
Materials Science, Multidisciplinary
Yuanyuan Cao, Quanzhong Ren, Rongzhang Hao, Zhiwei Sun
Summary: In recent years, there has been significant growth in the development of photothermal agents for photothermal therapy (PTT) in eradicating solid tumors. However, the effectiveness of PTT is hindered by challenges such as tumor thermotolerance, which can lead to inflammation, damage to normal organs, and tumor recurrence. This review explores innovative strategies to enhance PTT at mild temperatures, focusing on the apoptotic pathway. It also discusses recent advances in regulating heat shock proteins expression, autophagy level, free radical generation, and organelle targeting to overcome tumor thermotolerance, as well as combining mild-temperature PTT with other therapies for a superadditive effect. The review concludes with a discussion on the scientific and technical challenges of mild-temperature PTT for clinical translation.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Lihua Luo, Xiang Li, Junlei Zhang, Chunqi Zhu, Mengshi Jiang, Zhenyu Luo, Bing Qin, Yanqing Wang, Bin Chen, Yongzhong Du, Yan Lou, Jian You
Summary: Effective tumor vaccine is crucial in boosting immune system to produce more memory T cells, which has great potential for cancer prevention and therapy.
Article
Chemistry, Multidisciplinary
Ying Tian, Muhammad Rizwan Younis, Yatong Zhao, Kai Guo, Jiayingzi Wu, Longjiang Zhang, Peng Huang, Zhongqiu Wang
Summary: Researchers have developed a nanomodulator based on mesoporous polydopamine nanoparticles for combinational photothermal-immunotherapy. This nanomodulator improves immunotherapy outcomes by restoring immune suppression and providing thermal therapy for tumor treatment. The nanomodulator has excellent biocompatibility, water solubility, and imaging abilities. It can precisely deliver and release immune inhibitors at tumor sites, effectively reversing immune suppression and enhancing therapeutic efficacy.
Article
Nanoscience & Nanotechnology
Cunqing Kong, Banghao Xu, Guanhua Qiu, Meng Wei, Mengqi Zhang, Shengxian Bao, Jiali Tang, Lequn Li, JunJie Liu
Summary: This study explores the biomedical application of PTT/PDT combined with Anti-PD-L1 based on ICG@SANPs-cRGD nanomaterials for breast cancer treatment and demonstrates the potential of ICG@SANPs-cRGD as a multifunctional therapeutic platform for future cancer therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Environmental
Tongyao Wang, Tong Chen, Junlun Zhu, Suxiao Wang, Wei Wen, Xiuhua Zhang, Huadong Tang, Jichao Liang, Shengfu Wang, Huayu Xiong, Huayu Xiong
Summary: This study developed a novel nanoreactor that utilizes glucose oxidation to generate highly active radicals for starvation therapy and chemodynamic therapy. It also incorporates photothermal enhancement and release of copper ions for enhanced angiogenesis, thereby combating persistent inflammation and bacterial infection during wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Physical
Sasha You, Gang Ding, Bin Chi, Zhuoya Wang, Si Lu, Ling Li, Xiaolan Yu, Jing Wang
Summary: A trackable-imaging multifunctional cascade reactor was designed, which can be enriched in tumor cells and release GOx to generate H2O2 and oxygen radicals. Under MRI guidance, near-infrared light excitation at the optimal concentration promoted multienzyme activity in the tumor. The cytotoxicity and in vivo experiments confirmed the satisfactory therapeutic effect of the cascade reaction and photothermal therapy.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Engineering, Biomedical
Qianwen Yu, Xian Tang, Wei Zhao, Yue Qiu, Jiao He, Dandan Wan, Jianping Li, Xuhui Wang, Xuan He, Yayuan Liu, Man Li, Zhirong Zhang, Qin He
Summary: The combination of mild hyperthermia and immune checkpoint blockade treatment effectively suppressed tumor growth and metastasis; size-adjustable nanoparticles have great potential in improving cancer treatment outcomes.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Hwa Seung Han, Ki Young Choi
Summary: Photothermal therapy (PTT) is a promising noninvasive cancer treatment strategy, although current limitations include low photothermal conversion efficiency, low accumulation of agents in tumor tissue, and heat resistance in specific cancer types. Innovative nanomaterial-based approaches show potential for improving therapeutic outcomes and reducing side effects in PTT applications.
Article
Oncology
Xing Huang, Gang Zhang, Tingbo Liang
Summary: The lack of the TGFB signaling pathway in CD4(+) helper T cells induces remodeling of intratumoral vascular tissue, preventing tumor cells from receiving necessary nutrients and ultimately causing tumor cell death due to starvation. Blocking TGFB promotes tissue healing, leading to an effective anticancer immune response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Chemistry, Physical
Nan Yang, Changyu Cao, Hui Li, Ying Hong, Yu Cai, Xuejiao Song, Wenjun Wang, Xiaozhou Mou, Xiaochen Dong
Summary: Photothermal therapy (PTT) has gained considerable attention in cancer treatment for its unique features, and polymer-based photothermal agents (PTAs) have been widely employed in cancer diagnosis and PTT due to their competitive advantages, including customizable designs, controllable synthesis, excellent biocompatibility, negligible cytotoxicity, satisfactory photostability, and desirable photothermal effects.
Review
Chemistry, Physical
Nan Yang, Changyu Cao, Hui Li, Ying Hong, Yu Cai, Xuejiao Song, Wenjun Wang, Xiaozhou Mou, Xiaochen Dong
Summary: Scientists have made significant efforts in cancer control, with photothermal therapy (PTT) emerging as a promising treatment method. Polymer-based PTAs play a crucial role in cancer diagnosis and therapy, offering various advantages in terms of design, synthesis, biocompatibility, and therapeutic effects.
Article
Engineering, Biomedical
Ruxia Han, Yao Xiao, Qian Yang, Meng Pan, Ying Hao, Xinlong He, Jinrong Peng, Zhiyong Qian
Summary: Photothermal therapy (PTT) using water-soluble Ag2S nanoparticles (NPs) has shown promising results in cancer treatment. Studies have found that multiple PTT cycles with Ag2S NPs can inhibit primary tumor cell proliferation, reduce tumor recurrence, and alleviate metastasis by stimulating the immune response in a mouse breast cancer model.
Review
Chemistry, Multidisciplinary
Jun Zhou, Chen Cao, Xinlu Zhang, Xu Zhang, Jiansen Li, Hongzhang Deng, Sheng Wang
Summary: Phototherapies have made significant progress in cancer treatment, but face challenges. Gas therapy, which improves the level of specific gas at the tumor site, shows potential to overcome these challenges. Nanomedicine-based gas-assisted phototherapy has emerged as a promising strategy to enhance treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Weiwei Wu, Yan Yang, Zhuoying Liang, Xiling Song, Yadong Huang, Lin Qiu, Xiaozhong Qiu, Siming Yu, Wei Xue
Summary: This study demonstrated the effective strategy of utilizing near-infrared laser-induced simultaneous release of NO and alkyl radicals to inhibit tumor growth, achieved through the elaborately fabricated biocompatible free radical nanogenerator. Under NIR II laser irradiation, the nanogenerator can precisely control the release profiles of NO and alkyl radicals, displaying synergistic anticancer effects on breast tumors.
Article
Chemistry, Multidisciplinary
Mengshi Jiang, Wei Li, Chunqi Zhu, Xiang Li, Junlei Zhang, Zhenyu Luo, Bing Qin, Yongzhong Du, Lihua Luo, Jian You
Summary: The application of nanocarriers in delivering chemotherapeutic drugs to tumors is a hot research topic in cancer treatment. However, the high specificity of chemotherapy can suppress the immune system, which could be counteracted by blocking the PD-1 pathway to enhance treatment efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Lihua Luo, Xiang Li, Junlei Zhang, Chunqi Zhu, Mengshi Jiang, Zhenyu Luo, Bing Qin, Yanqing Wang, Bin Chen, Yongzhong Du, Yan Lou, Jian You
Summary: Effective tumor vaccine is crucial in boosting immune system to produce more memory T cells, which has great potential for cancer prevention and therapy.
Article
Engineering, Biomedical
Yingying Shi, Chunqi Zhu, Yu Liu, Yichao Lu, Xiang Li, Bing Qin, Zhenyu Luo, Lihua Luo, Mengshi Jiang, Junlei Zhang, Guannan Guan, Cheng Zheng, Jian You
Summary: A study has identified a novel vaccine carrier that enhances the activation and maturation of dendritic cells, leading to a stronger cytotoxic T lymphocyte response and improved host defense against cancer or infection. The findings shed new light on the design and optimization of vaccines for currently intractable diseases.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Yingying Shi, Yichao Lu, Chunqi Zhu, Zhenyu Luo, Xiang Li, Yu Liu, Mengshi Jiang, Xu Liu, Lihua Luo, Yongzhong Du, Jian You
Summary: Regulating lymphocytic ER unfolded protein response (UPR) could be a potential therapeutic breakthrough in alleviating graft rejection. These findings suggest that lymphocytic IRE1 alpha inactivation attenuates transplant rejection and prolongs graft survival, with limited effector function and memory commitment of host T-8. The combination of IRE1 alpha inhibition with immunosuppressant tacrolimus (FK506) shows an even higher immunosuppressive effect through synergistic regulation of inflammatory transcription factors.
Article
Chemistry, Multidisciplinary
Mengshi Jiang, Xiang Li, Junlei Zhang, Yichao Lu, Yingying Shi, Chunqi Zhu, Yu Liu, Bing Qin, Zhenyu Luo, Yongzhong Du, Lihua Luo, Ling Peng, Jian You
Summary: By inhibiting both ER stress and oxidative stress, M2-tumor associated macrophages (TAMs) can be effectively repolarized, providing significant implications for anti-tumor therapy.
Article
Chemistry, Multidisciplinary
Chunqi Zhu, Yingying Shi, Qingpo Li, Lihua Luo, Xiang Li, Zhenyu Luo, Yichao Lu, Junlei Zhang, Mengshi Jiang, Bing Qin, Weigen Qiu, Zhaolei Jin, Xindong Jiang, Jiandong Xiao, Jian You
Summary: The study demonstrated that the combination therapy of DTX-VNS plus alpha PD-1 initiated a potent anti-tumor response in multiple tumor models, leading to a significant reshaping of the tumor microenvironment. The optimal therapeutic efficacy may stem from the maximum therapeutic additive effects arising from the concomitant exposure of DTX-VNS and alpha PD-1 at the tumor site.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yichao Lu, Yingying Shi, Zhenyu Luo, Xuemeng Guo, Mengshi Jiang, Xiang Li, Junlei Zhang, Chunqi Zhu, Hang Yin, Bing Qin, Xu Liu, Jiaxin Huang, Yongzhong Du, Lihua Luo, Jian You
Summary: This study demonstrates that co-inhibiting hyperactivated XBP1 and redundant intracellular ROS through KT-NE can effectively reduce lipid accumulation in dysfunctional lipid-laden TIDCs, leading to the reactivation of TIDCs and restoration of their capacity to expand and stimulate tumor-specific T cells. Additionally, both KT-NE-treated TIDCs (adoptive transfer) and KT-NE itself can significantly improve the efficacy of DC-mediated immunotherapy and reduce tumor burden in malignant ovarian cancer (OvCa)-bearing mice.
Article
Chemistry, Multidisciplinary
Xu Liu, Yu Liu, Xiang Li, Jiaxin Huang, Xuemeng Guo, Junlei Zhang, Zhenyu Luo, Yingying Shi, Mengshi Jiang, Bing Qin, Yongzhong Du, Lihua Luo, Jian You
Summary: Transforming tumor cells into therapeutic vaccines using ER-targeting photodynamic therapy provides a clinically applicable and effective approach for cancer treatment.
Article
Chemistry, Multidisciplinary
Junlei Zhang, Sijie Wang, Xuemeng Guo, Yichao Lu, Xu Liu, Mengshi Jiang, Xiang Li, Bing Qin, Zhenyu Luo, Huihui Liu, Qingpo Li, Yong-Zhong Du, Lihua Luo, Jian You
Summary: The tumor microenvironment (TME) plays a crucial role in cancer treatment, especially immunotherapy. This study introduces a multivesicular liposome technology that continuously supplies alkaline L-arginine (L-arg) to alter the acidity and L-arg deficiency in the TME. By selectively knocking down the CAT-2 transporter, the strategy maintains L-arg starvation in tumors while enriching tumor-killing immune cells in the TME. The results demonstrate improved CD8+ T cell infiltration and activation, increased M1 macrophage proportion, inhibited melanoma growth, and prolonged survival. Additionally, when combined with anti-PD-1 antibody, the strategy shows a synergistic antitumor effect, reversing the low tumor response to immune checkpoint blockade therapy.
Article
Biotechnology & Applied Microbiology
Zhenyu Luo, Lihua Luo, Yichao Lu, Chunqi Zhu, Bing Qin, Mengshi Jiang, Xiang Li, Yingying Shi, Junlei Zhang, Yu Liu, Xinyu Shan, Hang Yin, Guannan Guan, Yongzhong Du, Ningtao Cheng, Jian You
Summary: A dual-binding magnetic nanoparticle platform was developed to enhance the efficacy of adoptive cell therapy (ACT) for solid tumors and reduce toxic side effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yichao Lu, Yingying Shi, Yu Liu, Zhenyu Luo, Junlei Zhang, Mengshi Jiang, Xiang Li, Xu Liu, Xuemeng Guo, Bing Qin, Hang Yin, Yongzhong Du, Yunqing Qiu, Yan Lou, Guannan Guan, Lihua Luo, Jian You
Summary: Dendritic cell (DC) vaccines are crucial for future anti-tumor immunotherapy, but current challenges include immunosuppressive factors and functional impairment. This study successfully addressed these issues by using an α-tocopherol nanoemulsion, resulting in improved immune activity and recognition ability of DC vaccines.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Xiang Li, Xuemeng Guo, Jiaxin Huang, Qing Lin, Bing Qin, Mengshi Jiang, Xinyu Shan, Zhenyu Luo, Junlei Zhang, Yingying Shi, Yichao Lu, Xu Liu, Yongzhong Du, Fuchun Yang, Lihua Luo, Jian You
Summary: Recruiting T cells to convert cold tumors into hot can prevent tumor immune evasion. However, tumors have evolved more mechanisms to achieve immune evasion, such as downregulating MHC I molecules expression or secreting immune suppression cytokines. Tumor immune evasion not only promotes tumor growth, but also weakens the efficacy of existing tumor immunotherapies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Lihua Luo, Zhenyu Luo, Junlei Zhang, Xu Liu, Jiaxin Huang, Sijie Wang, Hang Yin, Xuemeng Guo, Yilong Hu, Yichao Lu, Xinyu Shan, Huihui Liu, Yingying Shi, Yongzhong Du, Fuchun Yang, Jian You
Summary: This passage introduces a treatment strategy for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) and pulmonary fibrosis (PF). By designing a multistage targeted nanomicelle loaded with endoplasmic reticulum stress inhibitor and anti-inflammatory drug, the balance of macrophage polarization and restoration of endoplasmic reticulum homeostasis can be achieved, alleviating inflammation and ultimately resolving ALI and preventing PF.
Article
Engineering, Biomedical
Yu Liu, Xu Liu, Jiaxin Huang, Yingying Shi, Zhenyu Luo, Junlei Zhang, Xuemeng Guo, Mengshi Jiang, Xiang Li, Hang Yin, Bing Qin, Guannan Guan, Lihua Luo, Yun Zhou, Jian You
Summary: This study reports a novel mRNA vaccine delivery system using modified liposomes to efficiently induce tumor-specific immune responses. The system shows promising prophylactic effects and offers a strategy to address deficient tumor MHC-I expression.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Yingying Shi, Yu Liu, Jiaxin Huang, Zhenyu Luo, Xuemeng Guo, Mengshi Jiang, Xiang Li, Yichao Lu, Xu Liu, Xinyu Shan, Lihua Luo, Jian You
Summary: This study indicates that a simultaneous and coordinated mobilization of MHC-restricted immunity may enhance cancer therapy, providing new insights for cancer treatment.