Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy

CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis

(2020) Hui Yang et al.   Molecular Cancer

B cells and tertiary lymphoid structures promote immunotherapy response

(2020) Beth A. Helmink et al.   NATURE

Neoadjuvant checkpoint blockade for cancer immunotherapy

(2020) Suzanne L. Topalian et al.   SCIENCE

Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis

(2020) Cheng-Liang Kuo et al.   CANCER LETTERS

Remodeling tumor immune microenvironment via targeted blockade of PI3K-γ and CSF-1/CSF-1R pathways in tumor associated macrophages for pancreatic cancer therapy

(2020) Man Li et al.   JOURNAL OF CONTROLLED RELEASE

Targeting the Inositol-Requiring Enzyme-1 Pathway Efficiently Reverts Zika Virus-Induced Neurogenesis and Spermatogenesis Marker Perturbations

(2020) Hin Chu et al.   ACS Infectious Diseases

The Role of Tumor-Associated Macrophages in the Progression and Chemoresistance of Ovarian Cancer

(2020) Marek Nowak et al.   Cells

Mesoporous Bi-Containing Radiosensitizer Loading with DOX to Repolarize Tumor-Associated Macrophages and Elicit Immunogenic Tumor Cell Death to Inhibit Tumor Progression

(2020) Xiaojia Qin et al.   ACS Applied Materials & Interfaces

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

(2020) Martina Molgora et al.   CELL

The roles of tumor-associated macrophages in tumor angiogenesis and metastasis

(2020) Luo-Qin Fu et al.   CELLULAR IMMUNOLOGY

Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model

(2020) Sanne Van Campenhout et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

(2020) Julia M. D. Grandjean et al.   Nature Chemical Biology

Hypoxia Correlates With Poor Survival and M2 Macrophage Infiltration in Colorectal Cancer

(2020) Lina Qi et al.   Frontiers in Oncology

Enhancing anti-tumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors

(2019) K M Heinhuis et al.   ANNALS OF ONCOLOGY

Endoplasmic Reticulum Stress Responses in Intratumoral Immune Cells: Implications for Cancer Immunotherapy

(2019) Minkyung Song et al.   TRENDS IN IMMUNOLOGY

Synergetic Functional Nanocomposites Enhance Immunotherapy in Solid Tumors by Remodeling the Immunoenvironment

(2019) Linnan Yang et al.   Advanced Science

Breast phyllodes tumors recruit and repolarize tumor-associated macrophages via secreting CCL5 to promote malignant progression which can be inhibited by CCR5 inhibition Therapy

(2019) Hai Hu et al.   CLINICAL CANCER RESEARCH

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Tumor-associated macrophages: role in cancer development and therapeutic implications

(2019) Arash Salmaninejad et al.   CELLULAR ONCOLOGY

Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth

(2019) Jiahao Zhang et al.   Redox Biology

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

(2019) Yuxin Lin et al.   Journal of Hematology & Oncology

Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease

(2019) Shijia Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology

(2019) Andrew J. Takeda et al.   Nature Communications

Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

(2019) Liangrong Shi et al.   Nature Communications

MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment

(2019) Douglas D. Fang et al.   Journal for ImmunoTherapy of Cancer

Iron chelated melanin-like nanoparticles for tumor-associated macrophage repolarization and cancer therapy

(2019) Lei Rong et al.   BIOMATERIALS

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase

(2019) Mario A. Lauterbach et al.   IMMUNITY

Cancer Immunotherapy: PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy (Adv. Mater. 22/2018)

(2018) Xudong Zhang et al.   ADVANCED MATERIALS

Progress and challenges of predictive biomarkers of anti PD-1/PD-L1 immunotherapy: A systematic review

(2018) Feifei Teng et al.   CANCER LETTERS

Inhibition of Rspo-Lgr4 facilitates checkpoint blockade therapy by switching macrophage polarization

(2018) Binghe Tan et al.   CANCER RESEARCH

Macrophage plasticity, polarization, and function in health and disease

(2018) Abbas Shapouri-Moghaddam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

IRE1α RNase–dependent lipid homeostasis promotes survival in Myc-transformed cancers

(2018) Hong Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Repolarization of Tumor-Associated Macrophages in a Genetically Engineered Nonsmall Cell Lung Cancer Model by Intraperitoneal Administration of Hyaluronic Acid-Based Nanoparticles Encapsulating MicroRNA-125b

(2018) Neha N. Parayath et al.   NANO LETTERS

Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti–PD-1 treatment

(2018) Elisa Peranzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

The PERK Arm of the Unfolded Protein Response Regulates Mitochondrial Morphology during Acute Endoplasmic Reticulum Stress

(2018) Justine Lebeau et al.   Cell Reports

Use of PD-1 Targeting, Macrophage Infiltration, and IDO Pathway Activation in Sarcomas

(2018) Maud Toulmonde et al.   JAMA Oncology

Immune biomarkers of response to immune-checkpoint inhibitors in head and neck squamous cell carcinoma

(2018) M Oliva et al.   ANNALS OF ONCOLOGY

IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity

(2018) Minkyung Song et al.   NATURE

Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer

(2018) Marta Helena Kubala et al.   Cell Reports

Intermittent Hypoxia Enhances THP-1 Monocyte Adhesion and Chemotaxis and Promotes M1 Macrophage Polarization via RAGE

(2018) Jing Zhou et al.   Biomed Research International

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

(2017) Anthony T. Phan et al.   IMMUNITY

Metabolic regulation of macrophage phenotype and function

(2017) Shilpi Saha et al.   IMMUNOLOGICAL REVIEWS

Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases

(2017) Andrey V. Cybulsky   Nature Reviews Nephrology

Macrophage Immunometabolism: Where Are We (Going)?

(2017) Jan Van den Bossche et al.   TRENDS IN IMMUNOLOGY

ROS in Cancer: The Burning Question

(2017) Iok In Christine Chio et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial ROS Production Protects the Intestine from Inflammation through Functional M2 Macrophage Polarization

(2017) Laura Formentini et al.   Cell Reports

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma

(2017) Ingunn M. Stromnes et al.   Cancer Immunology Research

PI3Kγ is a molecular switch that controls immune suppression

(2016) Megan M. Kaneda et al.   NATURE

Integrating immunometabolism and macrophage diversity

(2016) Maxim N. Artyomov et al.   SEMINARS IN IMMUNOLOGY

Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

(2016) Valsamo Anagnostou et al.   Cancer Discovery

Intestinal IRE1 Is Required for Increased Triglyceride Metabolism and Longer Lifespan under Dietary Restriction

(2016) Nuno Miguel Luis et al.   Cell Reports

STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation

(2016) Dongyao Yan et al.   Cell Reports

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy

(2015) Thati Madhusudhan et al.   Nature Communications

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models

(2015) Marine M Leblond et al.   OncoImmunology

Cellular Metabolism and Macrophage Functional Polarization

(2014) Linnan Zhu et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Accelerated Development of Pulmonary Fibrosis via Cu,Zn-superoxide Dismutase-induced Alternative Activation of Macrophages

(2013) Chao He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential for therapeutic manipulation of the UPR in disease

(2013) Sang Won Park et al.   Seminars in Immunopathology

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

(2012) Xing Cai et al.   Journal of Molecular Cell Biology