Genetic basis of a spontaneous mutation’s expressivity

Microbe-dependent heterosis in maize

(2021) Maggie R. Wagner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis

(2020) Abeer Prakash Singh et al.   MOLECULAR CELL

CRISPR-Cas9 Gene Editing for Sickle Cell Disease and β-Thalassemia

(2020) Haydar Frangoul et al.   NEW ENGLAND JOURNAL OF MEDICINE

The complex role of genetic background in shaping the effects of spontaneous and induced mutations

(2020) Ilan Goldstein et al.   YEAST

Complex modifier landscape underlying genetic background effects

(2019) Jing Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Layers of Cryptic Genetic Variation Underlie a Yeast Complex Trait

(2019) Jonathan T. Lee et al.   GENETICS

Higher-fitness yeast genotypes are less robust to deleterious mutations

(2019) Milo S. Johnson et al.   SCIENCE

The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae

(2019) Marco Galardini et al.   Molecular Systems Biology

Analysis of Epistasis in Natural Traits Using Model Organisms

(2018) Richard F. Campbell et al.   TRENDS IN GENETICS

The complex underpinnings of genetic background effects

(2018) Martin N. Mullis et al.   Nature Communications

Epistasis: Searching for Interacting Genetic Variants Using Crosses

(2017) Ian M. Ehrenreich   GENETICS

Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast

(2017) Simon K G Forsberg et al.   NATURE GENETICS

How well do you know your mutation? Complex effects of genetic background on expressivity, complementation, and ordering of allelic effects

(2017) Christopher H. Chandler et al.   PLoS Genetics

Epistasis: Searching for Interacting Genetic Variants Using Crosses

(2017) Ian M. Ehrenreich   GENETICS

Analysis of 589,306 genomes identifies individuals resilient to severe Mendelian childhood diseases

(2016) Rong Chen et al.   NATURE BIOTECHNOLOGY

Health and population effects of rare gene knockouts in adult humans with related parents

(2016) V. M. Narasimhan et al.   SCIENCE

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross

(2016) Matthew B. Taylor et al.   Nature Communications

One step engineering of the small-subunit ribosomal RNA using CRISPR/Cas9

(2016) Krishna Kannan et al.   Scientific Reports

Modifiers of the Genotype–Phenotype Map: Hsp90 and Beyond

(2016) Rachel Schell et al.   PLOS BIOLOGY

Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90

(2016) Kerry A. Geiler-Samerotte et al.   PLOS BIOLOGY

Multi-locus Genotypes Underlying Temperature Sensitivity in a Mutationally Induced Trait

(2016) Jonathan T. Lee et al.   PLoS Genetics

Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction

(2016) Takeshi Matsui et al.   PLoS Genetics

Genome-Assisted Prediction of Quantitative Traits Using the R Package sommer

(2016) Giovanny Covarrubias-Pazaran   PLoS One

Natural Variation in Gene Expression Modulates the Severity of Mutant Phenotypes

(2015) Victoria Vu et al.   CELL

Higher-order genetic interactions and their contribution to complex traits

(2015) Matthew B. Taylor et al.   TRENDS IN GENETICS

New vectors for simple and streamlined CRISPR-Cas9 genome editing inSaccharomyces cerevisiae

(2015) Marian F. Laughery et al.   YEAST

Genetic interactions contribute less than additive effects to quantitative trait variation in yeast

(2015) Joshua S. Bloom et al.   Nature Communications

Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions

(2015) Matthew B. Taylor et al.   PLoS Genetics

Wild worm embryogenesis harbors ubiquitous polygenic modifier variation

(2015) Annalise B Paaby et al.   eLife

mixtools: AnRPackage for Analyzing Finite Mixture Models

(2015) Tatiana Benaglia et al.   Journal of Statistical Software

On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms

(2014) Mark L. Siegal et al.   Annual Review of Ecology Evolution and Systematics

Causes and Consequences of Genetic Background Effects Illuminated by Integrative Genomic Analysis

(2014) Christopher H. Chandler et al.   GENETICS

Cryptic genetic variation: evolution's hidden substrate

(2014) Annalise B. Paaby et al.   NATURE REVIEWS GENETICS

Global epistasis makes adaptation predictable despite sequence-level stochasticity

(2014) S. Kryazhimskiy et al.   SCIENCE

Genetic Interactions Involving Five or More Genes Contribute to a Complex Trait in Yeast

(2014) Matthew B. Taylor et al.   PLoS Genetics

Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

(2013) David N. Cooper et al.   HUMAN GENETICS

Finding the sources of missing heritability in a yeast cross

(2013) Joshua S. Bloom et al.   NATURE

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

(2013) Trudy F. C. Mackay   NATURE REVIEWS GENETICS

Does your gene need a background check? How genetic background impacts the analysis of mutations, genes, and evolution

(2013) Christopher H. Chandler et al.   TRENDS IN GENETICS

The Conditional Nature of Genetic Interactions: The Consequences of Wild-Type Backgrounds on Mutational Interactions in a Genome-Wide Modifier Screen

(2013) Sudarshan Chari et al.   PLoS Genetics

Shrinkage Estimation of the Realized Relationship Matrix

(2012) Jeffrey B. Endelman et al.   G3-Genes Genomes Genetics

Genetic Variation and the Fate of Beneficial Mutations in Asexual Populations

(2011) Gregory I. Lang et al.   GENETICS

Saccharomyces Genome Database: the genomics resource of budding yeast

(2011) J. M. Cherry et al.   NUCLEIC ACIDS RESEARCH

Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms

(2010) Daniel F. Jarosz et al.   Annual Review of Genetics

Maintenance and expression of the S. cerevisiae mitochondrial genome—From genetics to evolution and systems biology

(2010) Kamil A. Lipinski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Variability in gene expression underlies incomplete penetrance

(2010) Arjun Raj et al.   NATURE

Genotype to Phenotype: A Complex Problem

(2010) R. D. Dowell et al.   SCIENCE

Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation

(2010) D. F. Jarosz et al.   SCIENCE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Polymorphisms in Multiple Genes Contribute to the Spontaneous Mitochondrial Genome Instability of Saccharomyces cerevisiae S288C Strains

(2009) L. N. Dimitrov et al.   GENETICS

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Pleiotropic effects of the yeast Sal1 and Aac2 carriers on mitochondrial function via an activity distinct from adenine nucleotide transport

(2008) Blanka Kucejova et al.   MOLECULAR GENETICS AND GENOMICS

High-resolution mapping of meiotic crossovers and non-crossovers in yeast

(2008) Eugenio Mancera et al.   NATURE

Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis

(2008) H. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA