Modifiers of the Genotype–Phenotype Map: Hsp90 and Beyond

Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits

(2016) Sohini Chakrabortee et al.   CELL

Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross

(2016) Matthew B. Taylor et al.   Nature Communications

Powerful decomposition of complex traits in a diploid model

(2016) Johan Hallin et al.   Nature Communications

Selection Transforms the Landscape of Genetic Variation Interacting with Hsp90

(2016) Kerry A. Geiler-Samerotte et al.   PLOS BIOLOGY

Genetic assimilation: a review of its potential proximate causes and evolutionary consequences

(2015) Ian M. Ehrenreich et al.   ANNALS OF BOTANY

Higher-order genetic interactions and their contribution to complex traits

(2015) Matthew B. Taylor et al.   TRENDS IN GENETICS

Genetic interactions contribute less than additive effects to quantitative trait variation in yeast

(2015) Joshua S. Bloom et al.   Nature Communications

Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions

(2015) Matthew B. Taylor et al.   PLoS Genetics

On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms

(2014) Mark L. Siegal et al.   Annual Review of Ecology Evolution and Systematics

Cryptic genetic variation: evolution's hidden substrate

(2014) Annalise B. Paaby et al.   NATURE REVIEWS GENETICS

Finding the sources of missing heritability in a yeast cross

(2013) Joshua S. Bloom et al.   NATURE

Epistasis and quantitative traits: using model organisms to study gene–gene interactions

(2013) Trudy F. C. Mackay   NATURE REVIEWS GENETICS

Variance Heterogeneity in Saccharomyces cerevisiae Expression Data: Trans-Regulation and Epistasis

(2013) Ronald M. Nelson et al.   PLoS One

Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish

(2013) N. Rohner et al.   SCIENCE

Histone Variant HTZ1 Shows Extensive Epistasis with, but Does Not Increase Robustness to, New Mutations

(2013) Joshua B. Richardson et al.   PLoS Genetics

Hsp90 is important for fecundity, longevity, and buffering of cryptic deleterious variation in wild fly populations

(2012) Bing Chen et al.   BMC EVOLUTIONARY BIOLOGY

Prions are a common mechanism for phenotypic inheritance in wild yeasts

(2012) Randal Halfmann et al.   NATURE

Detecting Major Genetic Loci Controlling Phenotypic Variability in Experimental Crosses

(2011) Lars Rönnegård et al.   GENETICS

Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms

(2010) Daniel F. Jarosz et al.   Annual Review of Genetics

Chromatin regulators as capacitors of interspecies variations in gene expression

(2010) Itay Tirosh et al.   Molecular Systems Biology

Dissection of genetically complex traits with extremely large pools of yeast segregants

(2010) Ian M. Ehrenreich et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation

(2010) D. F. Jarosz et al.   SCIENCE

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

Robustness: mechanisms and consequences

(2009) Joanna Masel et al.   TRENDS IN GENETICS

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS

Defining genetic interaction

(2008) R. Mani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP90-buffered genetic variation is common in Arabidopsis thaliana

(2008) T. A. Sangster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HSP90 affects the expression of genetic variation and developmental stability in quantitative traits

(2008) T. A. Sangster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionary potential of hidden genetic variation

(2008) A LEROUZIC et al.   TRENDS IN ECOLOGY & EVOLUTION

Network Hubs Buffer Environmental Variation in Saccharomyces cerevisiae

(2008) Sasha F Levy et al.   PLOS BIOLOGY