Soluble Human Angiotensin- Converting Enzyme 2 as a Potential Therapeutic Tool for COVID-19 is Produced at High Levels In Nicotiana benthamiana Plant With Potent Anti-SARS-CoV-2 Activity

Development of Plant-Produced Recombinant ACE2-Fc Fusion Protein as a Potential Therapeutic Agent Against SARS-CoV-2

(2021) Konlavat Siriwattananon et al.   Frontiers in Plant Science

A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids

(2021) Jan Wysocki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Plant-Produced Glycosylated and In Vivo Deglycosylated Receptor Binding Domain Proteins of SARS-CoV-2 Induce Potent Neutralizing Responses in Mice

(2021) Tarlan Mamedov et al.   Viruses-Basel

Plant-Based COVID-19 Vaccines: Current Status, Design, and Development Strategies of Candidate Vaccines

(2021) Puna Maya Maharjan et al.   Vaccines

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Co‐expression of human calreticulin significantly improves the production of HIV gp140 and other viral glycoproteins in plants

(2020) E Margolin et al.   PLANT BIOTECHNOLOGY JOURNAL

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine

(2020) Wanbo Tai et al.   Cellular & Molecular Immunology

Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodies

(2020) Chunyan Yi et al.   Cellular & Molecular Immunology

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

Engineering the Plant Secretory Pathway for the Production of Next-Generation Pharmaceuticals

(2020) Emmanuel A. Margolin et al.   TRENDS IN BIOTECHNOLOGY

Neutralization of SARS-CoV-2 spike pseudotyped virus by recombinant ACE2-Ig

(2020) Changhai Lei et al.   Nature Communications

Recombinant human ACE2: potential therapeutics of SARS-CoV-2 infection and its complication

(2020) Xiaocong Pang et al.   ACTA PHARMACOLOGICA SINICA

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

(2020) Kui K. Chan et al.   SCIENCE

Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production

(2020) Balamurugan Shanmugaraj et al.   Plants-Basel

The Emergency Response Capacity of Plant-Based Biopharmaceutical Manufacturing-What It Is and What It Could Be

(2020) Daniel Tusé et al.   Frontiers in Plant Science

Baculovirus-free insect cell expression system for high yield antibody and antigen production

(2020) Janin Korn et al.   Scientific Reports

Engineering, and production of functionally active human Furin in N. benthamiana plant: In vivo post-translational processing of target proteins by Furin in plants

(2019) Tarlan Mamedov et al.   PLoS One

The renin angiotensin aldosterone system and its therapeutic targets

(2019) Katrina M. Mirabito Colafella et al.   EXPERIMENTAL EYE RESEARCH

A Plant-Produced in vivo deglycosylated full-length Pfs48/45 as a Transmission-Blocking Vaccine Candidate against malaria

(2019) Tarlan Mamedov et al.   Scientific Reports

Techno‐economic analysis of a plant‐based platform for manufacturing antimicrobial proteins for food safety

(2019) Matthew J. McNulty et al.   BIOTECHNOLOGY PROGRESS

Three unrelated protease inhibitors enhance accumulation of pharmaceutical recombinant proteins in Nicotiana benthamiana

(2018) Friederike Grosse-Holz et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of complex viral glycoproteins in plants as vaccine immunogens

(2018) Emmanuel Margolin et al.   PLANT BIOTECHNOLOGY JOURNAL

Improving agroinfiltration-based transient gene expression in Nicotiana benthamiana

(2018) Karlah Norkunas et al.   Plant Methods

In vivo production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expression with Endo-β-N-acetylglucosaminidase H (Endo H) of Streptomyces plicatus

(2017) Tarlan Mamedov et al.   PLoS One

Techno-economic analysis of a transient plant-based platform for monoclonal antibody production

(2016) Somen Nandi et al.   mAbs

Angiotensin-(1-5), an active mediator of renin-angiotensin system, stimulates ANP secretion via Mas receptor

(2016) Lamei Yu et al.   PEPTIDES

Co-expression of the protease furin inNicotiana benthamianaleads to efficient processing of latent transforming growth factor-β1 into a biologically active protein

(2016) Ruud H. P. Wilbers et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of Functionally Active and Immunogenic Non-Glycosylated Protective Antigen from Bacillus anthracis in Nicotiana benthamiana by Co-Expression with Peptide-N-Glycosidase F (PNGase F) of Flavobacterium meningosepticum

(2016) Tarlan Mamedov et al.   PLoS One

Commercial-scale biotherapeutics manufacturing facility for plant-made pharmaceuticals

(2015) Barry R. Holtz et al.   PLANT BIOTECHNOLOGY JOURNAL

Engineering and expression of a human rotavirus candidate vaccine in Nicotiana benthamiana

(2015) Francisco F. P. G. Pêra et al.   Virology Journal

Techno-Economic Analysis of Horseradish Peroxidase Production Using a Transient Expression System in Nicotiana benthamiana

(2014) David Richard Walwyn et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens

(2014) Nathalie Landry et al.   CLINICAL IMMUNOLOGY

Extending Serum Half-life of Albumin by Engineering Neonatal Fc Receptor (FcRn) Binding

(2014) Jan Terje Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral Delivery of ACE2/Ang-(1–7) Bioencapsulated in Plant Cells Protects against Experimental Uveitis and Autoimmune Uveoretinitis

(2014) Pollob K Shil et al.   MOLECULAR THERAPY

Plant-based vaccines against viruses

(2014) Edward P Rybicki   Virology Journal

Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections

(2014) Zhen Zou et al.   Nature Communications

Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury

(2014) Penghui Yang et al.   Scientific Reports

Manufacturing Economics of Plant-Made Biologics: Case Studies in Therapeutic and Industrial Enzymes

(2014) Daniel Tusé et al.   Biomed Research International

Optimization and Utilization of Agrobacterium-mediated Transient Protein Production in Nicotiana

(2014) Moneim Shamloul et al.   Jove-Journal of Visualized Experiments

Receptor recognition and cross-species infections of SARS coronavirus

(2013) Fang Li   ANTIVIRAL RESEARCH

Pharmacokinetics and Pharmacodynamics of Recombinant Human Angiotensin-Converting Enzyme 2 in Healthy Human Subjects

(2013) Manuel Haschke et al.   CLINICAL PHARMACOKINETICS

Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

(2013) Aleš Berlec et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

A plant-produced protective antigen vaccine confers protection in rabbits against a lethal aerosolized challenge withBacillus anthracisAmes spores

(2013) Jessica A. Chichester et al.   Human Vaccines & Immunotherapeutics

Production of non-glycosylated recombinant proteins inNicotiana benthamianaplants by co-expressing bacterial PNGase F

(2012) Tarlan Mamedov et al.   PLANT BIOTECHNOLOGY JOURNAL

Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method

(2012) Yoshio Araki et al.   PLoS One

High-Level Transient Expression of ER-Targeted Human Interleukin 6 in Nicotiana benthamiana

(2012) Henrik Nausch et al.   PLoS One

A Plant-Produced Pfs230 Vaccine Candidate Blocks Transmission of Plasmodium falciparum

(2011) Christine E. Farrance et al.   Clinical and Vaccine Immunology

Safety of plant-made pharmaceuticals: Product development and regulatory considerations based on case studies of two autologous human cancer vaccines

(2011) Daniel Tusé   Human vaccines & immunotherapeutics

Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist

(2011) Roelie M Wösten-van Asperen et al.   JOURNAL OF PATHOLOGY

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

Using plant cells as influenza vaccine substrates

(2009) Jessica A Chichester et al.   Expert Review of Vaccines

Transient co-expression for fast and high-yield production of antibodies with human-likeN-glycans in plants

(2009) Louis-P. Vézina et al.   PLANT BIOTECHNOLOGY JOURNAL

pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants

(2009) Frank Sainsbury et al.   PLANT BIOTECHNOLOGY JOURNAL

A plant-produced influenza subunit vaccine protects ferrets against virus challenge

(2008) Vadim Mett et al.   Influenza and Other Respiratory Viruses