Gut Microbiome-Mediated Alteration of Immunity, Inflammation, and Metabolism Involved in the Regulation of Non-alcoholic Fatty Liver Disease

Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy

(2020) John Y. L. Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Indole Alleviates Diet‐induced Hepatic Steatosis and Inflammation in a Manner Involving Myeloid Cell PFKFB3

(2020) Linqiang Ma et al.   HEPATOLOGY

Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole

(2020) Jingyun Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

(2020) Steven Zhao et al.   NATURE

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

SCFA: mechanisms and functional importance in the gut

(2020) Camille Martin-Gallausiaux et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Gut Microbiota Dysbiosis in Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease: A Cross-Sectional Study in Taiwan

(2020) Ming-Chao Tsai et al.   Nutrients

Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis

(2020) Stephen A. Harrison et al.   GASTROENTEROLOGY

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

(2020) Xiang Zhang et al.   GUT

Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis

(2020) Shanshan Qiao et al.   Cell Reports

Intestinal Flora as a Potential Strategy to Fight SARS-CoV-2 Infection

(2020) Li-Hong He et al.   Frontiers in Microbiology

Impact of the source of fermentable carbohydrate on SCFA production by human gut microbiota in vitro - a systematic scoping review and secondary analysis

(2020) Hannah C. Harris et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease

(2020) S.R. Sharpton et al.   Cell Metabolism

Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention

(2020) Daniel Q. Huang et al.   Nature Reviews Gastroenterology & Hepatology

The role of the gut microbiome and diet in the pathogenesis of non-alcoholic fatty liver disease

(2020) Erica Jennison et al.   Clinical and Molecular Hepatology

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

An Historical Review of Phenylacetic Acid

(2019) Sam D Cook   PLANT AND CELL PHYSIOLOGY

NASH in Lean Individuals

(2019) Ramy Younes et al.   SEMINARS IN LIVER DISEASE

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

(2019) Kai Wang et al.   Cell Reports

Alterations in the relative abundance of Faecalibacterium prausnitzii correlate with changes in fecal calprotectin in patients with ileal Crohn’s disease: a longitudinal study

(2019) Olle Björkqvist et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Microbiome Signatures Associated with Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease

(2019) Jeffrey B. Schwimmer et al.   GASTROENTEROLOGY

Randomized, Double-blind, Placebo-controlled Study of a Multispecies Probiotic Mixture in Nonalcoholic Fatty Liver Disease

(2019) Sang Bong Ahn et al.   Scientific Reports

Gut Microbiota and Risk of Persistent Nonalcoholic Fatty Liver Diseases

(2019) Han-Na Kim et al.   Journal of Clinical Medicine

New insights and therapeutic implication of gut microbiota in non-alcoholic fatty liver disease and its associated liver cancer

(2019) Niama Ezzaidi et al.   CANCER LETTERS

Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

(2019) Rohit Loomba et al.   Cell Metabolism

Lean NAFLD : A Distinct Entity Shaped by Differential Metabolic Adaptation

(2019) Fei Chen et al.   HEPATOLOGY

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

(2019) Jing Yuan et al.   Cell Metabolism

The gut-liver axis in liver disease: pathophysiological basis for therapy

(2019) Agustín Albillos et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies

(2019) Hamed Ebrahimzadeh Leylabadlo et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Increased liver localization of lipopolysaccharides in human and experimental non‐alcoholic fatty liver disease

(2019) Guido Carpino et al.   HEPATOLOGY

Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives

(2019) Haiming Hu et al.   JOURNAL OF GASTROENTEROLOGY

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

(2018) David Højland Ipsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histological improvement of non-alcoholic steatohepatitis with a prebiotic: a pilot clinical trial

(2018) Marc R. Bomhof et al.   EUROPEAN JOURNAL OF NUTRITION

Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD

(2018) Cyrielle Caussy et al.   HEPATOLOGY

Sodium Butyrate Ameliorates High-Fat-Diet-Induced Non-alcoholic Fatty Liver Disease through Peroxisome Proliferator-Activated Receptor α-Mediated Activation of β Oxidation and Suppression of Inflammation

(2018) Bo Sun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice

(2018) Shenhai Gong et al.   JOURNAL OF HEPATOLOGY

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis: a role for bifidobacteria and lactobacilli?

(2018) Borja Sánchez   Nature Reviews Gastroenterology & Hepatology

The gut–liver axis and the intersection with the microbiome

(2018) Anupriya Tripathi et al.   Nature Reviews Gastroenterology & Hepatology

Interactions of commensal and pathogenic microorganisms with the intestinal mucosal barrier

(2018) Eric C. Martens et al.   NATURE REVIEWS MICROBIOLOGY

Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease

(2018) Qinwei Yu et al.   PHARMACOLOGY & THERAPEUTICS

Characteristics of fecal microbiota in non-alcoholic fatty liver disease patients

(2018) Fan Li et al.   Science China-Life Sciences

Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From “two hit theory” to “multiple hit model”

(2018) Yan-Lan Fang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance

(2018) Hannah E. Da Silva et al.   Scientific Reports

The Association of Gut Microbiota with Nonalcoholic Steatohepatitis in Thais

(2018) Abhasnee Sobhonslidsuk et al.   Biomed Research International

Dynamics of metatranscription in the inflammatory bowel disease gut microbiome

(2018) Melanie Schirmer et al.   Nature Microbiology

The effects of dietary supplementation with inulin and inulin-propionate ester on hepatic steatosis in adults with non-alcoholic fatty liver disease

(2018) Edward S. Chambers et al.   DIABETES OBESITY & METABOLISM

Investigations of Bacteroides spp. towards next-generation probiotics

(2018) Huizi Tan et al.   FOOD RESEARCH INTERNATIONAL

Small metabolites, possible big changes: a microbiota-centered view of non-alcoholic fatty liver disease

(2018) Huikuan Chu et al.   GUT

Global Perspectives on Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis

(2018) Zobair Younossi et al.   HEPATOLOGY

Liraglutide modulates gut microbiota and reduces NAFLD in obese mice

(2018) GV Moreira et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Publisher Correction: Alcoholic liver disease

(2018) Helmut K. Seitz et al.   Nature Reviews Disease Primers

Nonalcoholic Fatty Liver Disease

(2018) Xiao Jing Wang et al.   ANNALS OF INTERNAL MEDICINE

The role of the microbiome in NAFLD and NASH

(2018) Aleksandra A Kolodziejczyk et al.   EMBO Molecular Medicine

Non-alcoholic fatty liver disease – A global public health perspective

(2018) Zobair M. Younossi   JOURNAL OF HEPATOLOGY

Gut microbiota dysbiosis in patients with non-alcoholic fatty liver disease

(2017) Feng Shen et al.   Hepatobiliary & Pancreatic Diseases International

Faecalibacterium prausnitzii treatment improves hepatic health and reduces adipose tissue inflammation in high-fat fed mice

(2017) Eveliina Munukka et al.   ISME Journal

Clostridium butyricum B1 alleviates high-fat diet-induced steatohepatitis in mice via enterohepatic immunoregulation

(2017) Da Zhou et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Effects of Probiotics on Nonalcoholic Fatty Liver Disease in Obese Children and Adolescents

(2017) Fatemeh Famouri et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Determination of certain bacterial groups in gut microbiota and endotoxin levels in patients with nonalcoholic steatohepatitis

(2017) Ceren Ozkul et al.   Turkish Journal of Gastroenterology

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

(2017) Patrice D. Cani et al.   Frontiers in Microbiology

Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota

(2017) Da Zhou et al.   Scientific Reports

Protective effects of Lactobacillus rhamnosus GG against dyslipidemia in high-fat diet-induced obese mice

(2016) Bobae Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

Choline metabolites

(2016) Tangi Smallwood et al.   CURRENT OPINION IN LIPIDOLOGY

Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol

(2016) Khalidur Rahman et al.   GASTROENTEROLOGY

Microbiota-induced obesity requires farnesoid X receptor

(2016) Ava Parséus et al.   GUT

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis

(2016) Benjamin Lelouvier et al.   HEPATOLOGY

Gut microbiota profiling of pediatric nonalcoholic fatty liver disease and obese patients unveiled by an integrated meta-omics-based approach

(2016) Federica Del Chierico et al.   HEPATOLOGY

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota

(2016) Jérôme Boursier et al.   HEPATOLOGY

Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis

(2016) Divya P. Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

(2016) Gregory Thomas Brown et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)

(2016) Elena Buzzetti et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Linking the Microbiota, Chronic Disease, and the Immune System

(2016) Timothy W. Hand et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Beneficial Effect of Synbiotic Supplementation on Hepatic Steatosis and Anthropometric Parameters, But Not on Gut Permeability in a Population with Nonalcoholic Steatohepatitis

(2016) Silvia Ferolla et al.   Nutrients

Choline, Its Potential Role in Nonalcoholic Fatty Liver Disease, and the Case for Human and Bacterial Genes

(2016) Jill L Sherriff et al.   Advances in Nutrition

Faecalibacterium prausnitzii phylotypes in type two diabetic, obese, and lean control subjects

(2016) B. Hippe et al.   Beneficial Microbes

Altered Fecal Microbiota Correlates with Liver Biochemistry in Nonobese Patients with Non-alcoholic Fatty Liver Disease

(2016) Baohong Wang et al.   Scientific Reports

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Effects of Insulin Glargine and Liraglutide Therapy on Liver Fat as Measured by Magnetic Resonance in Patients With Type 2 Diabetes: A Randomized Trial

(2015) An Tang et al.   DIABETES CARE

Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis

(2015) Won Sohn et al.   DIGESTIVE DISEASES AND SCIENCES

Gut–Liver Axis in Alcoholic Liver Disease

(2015) Gyongyi Szabo   GASTROENTEROLOGY

Heat Killed Lactobacillus reuteri GMNL-263 Reduces Fibrosis Effects on the Liver and Heart in High Fat Diet-Hamsters via TGF-β Suppression

(2015) Wei-Jen Ting et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects of Multistrain Probiotic Supplementation on Glycemic and Inflammatory Indices in Patients with Nonalcoholic Fatty Liver Disease: A Double-Blind Randomized Clinical Trial

(2015) Abbaszadeh Sepideh et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

TGR5 and Immunometabolism: Insights from Physiology and Pharmacology

(2015) Alessia Perino et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Nutritional Keys for Intestinal Barrier Modulation

(2015) Stefania De Santis et al.   Frontiers in Immunology

Nonalcoholic fatty liver disease

(2015) Elizabeth M. Brunt et al.   Nature Reviews Disease Primers

Randomised clinical trial: the beneficial effects of VSL#3 in obese children with non-alcoholic steatohepatitis

(2014) A. Alisi et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis

(2014) J. S. Bajaj et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice

(2014) Jinge Xin et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling

(2014) Agnieszka Płóciennikowska et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of probiotic yogurt consumption on metabolic factors in individuals with nonalcoholic fatty liver disease

(2014) S. Nabavi et al.   JOURNAL OF DAIRY SCIENCE

Short-chain fatty acids induce both effector and regulatory T cells by suppression of histone deacetylases and regulation of the mTOR–S6K pathway

(2014) J Park et al.   Mucosal Immunology

Lactobacillus plantarum NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease

(2014) Chuan Li et al.   Food & Function

Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease

(2013) Maitreyi Raman et al.   Clinical Gastroenterology and Hepatology

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma

(2013) Rui Liao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Fatty Liver Accompanies an Increase in Lactobacillus Species in the Hind Gut of C57BL/6 Mice Fed a High-Fat Diet

(2013) Huawei Zeng et al.   JOURNAL OF NUTRITION

BifidobacteriumCECT 7765 improves metabolic and immunological alterations associated with obesity in high-fat diet-fed mice

(2013) Paola Gauffin Cano et al.   Obesity

Molecular Characterization of the Fecal Microbiota in Patients with Nonalcoholic Steatohepatitis – A Longitudinal Study

(2013) Vincent Wai-Sun Wong et al.   PLoS One

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Gut microbiota-derived propionate reduces cancer cell proliferation in the liver

(2012) L B Bindels et al.   BRITISH JOURNAL OF CANCER

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells

(2011) T. Adar et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis

(2011) Michele Malaguarnera et al.   DIGESTIVE DISEASES AND SCIENCES

DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH

(2011) Erwin Gäbele et al.   JOURNAL OF HEPATOLOGY

Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin–glucan fiber improves host metabolic alterations induced by high-fat diet in mice

(2011) Audrey M. Neyrinck et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Association Between Composition of the Human Gastrointestinal Microbiome and Development of Fatty Liver With Choline Deficiency

(2010) Melanie D. Spencer et al.   GASTROENTEROLOGY

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Role of Alcohol Metabolism in Non-Alcoholic Steatohepatitis

(2010) Susan S. Baker et al.   PLoS One

Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine

(2009) Petra Louis et al.   FEMS MICROBIOLOGY LETTERS

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity