Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers
Authors
Keywords
Park8, dardarin, Neurodegeneration, Movement Disorders, Biomarkers, Microvesicles
Journal
Acta Neuropathologica Communications
Volume 5, Issue 1, Pages -
Publisher
Springer Nature
Online
2017-11-22
DOI
10.1186/s40478-017-0492-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease
- (2017) Andrew B. West EXPERIMENTAL NEUROLOGY
- Cerebrospinal fluid biomarkers and clinical features in leucine-rich repeat kinase 2 (LRRK2) mutation carriers
- (2016) Dolores Vilas et al. MOVEMENT DISORDERS
- Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease
- (2016) Kyle B. Fraser et al. MOVEMENT DISORDERS
- LRRK2 levels and phosphorylation in Parkinson's disease brain and cases with restricted Lewy bodies
- (2016) Nicolas Dzamko et al. MOVEMENT DISORDERS
- Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019SLRRK2carriers
- (2016) Kyle B. Fraser et al. NEUROLOGY
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- The G2019S LRRK2 mutation increases myeloid cell chemotactic responses and enhances LRRK2 binding to actin-regulatory proteins
- (2015) Mark S. Moehle et al. HUMAN MOLECULAR GENETICS
- Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression
- (2015) Anastasia G. Henry et al. HUMAN MOLECULAR GENETICS
- Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium
- (2015) Karen Marder et al. NEUROLOGY
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
- (2015) Reina N. Fuji et al. Science Translational Medicine
- Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies
- (2014) G. Skibinski et al. JOURNAL OF NEUROSCIENCE
- Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
- (2014) Mike A Nalls et al. NATURE GENETICS
- Disease Penetrance of Late-Onset Parkinsonism
- (2014) Joanne Trinh et al. JAMA Neurology
- LRRK2 secretion in exosomes is regulated by 14-3-3
- (2013) K. B. Fraser et al. HUMAN MOLECULAR GENETICS
- Parkinson disease phenotype in Ashkenazi jews with and withoutLRRK2G2019S mutations
- (2013) Roy N. Alcalay et al. MOVEMENT DISORDERS
- Exosome release of ADAM15 and the functional implications of human macrophage-derived ADAM15 exosomes
- (2012) Hee Doo Lee et al. FASEB JOURNAL
- MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein
- (2012) Hyun Jin Cho et al. HUMAN MOLECULAR GENETICS
- Identification and proteomic profiling of exosomes in human cerebrospinal fluid
- (2012) Jonathan M Street et al. Journal of Translational Medicine
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
- (2011) Philip J. Webber et al. JOURNAL OF MOLECULAR BIOLOGY
- Cerebrospinal fluid amyloid and tau in LRRK2 mutation carriers
- (2011) J. O. Aasly et al. NEUROLOGY
- Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2
- (2010) Christian Johannes Gloeckner et al. JOURNAL OF PROTEOME RESEARCH
- The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
- (2009) Elisa Greggio et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search