Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

Investigating the replicability of preclinical cancer biology

(2021) Timothy M Errington et al.   eLife

Challenges for assessing replicability in preclinical cancer biology

(2021) Timothy M Errington et al.   eLife

Addressing selective reporting of experiments through predefined exclusion criteria

(2020) Kleber Neves et al.   eLife

Epigenetic Enzyme Mutations: Role in Tumorigenesis and Molecular Inhibitors

(2019) Mei Han et al.   Frontiers in Oncology

On the value of preprints: An early career researcher perspective

(2019) Sarvenaz Sarabipour et al.   PLOS BIOLOGY

Genes CEP55, FOXD3, FOXF2, GNAO1, GRIA4, and KCNA5 as potential diagnostic biomarkers in colorectal cancer

(2019) Nina Hauptman et al.   BMC Medical Genomics

Engineering Multidimensional Evolutionary Forces to Combat Cancer

(2019) Caroline E. McCoach et al.   Cancer Discovery

Combination of Immunotherapy With Targeted Therapy: Theory and Practice in Metastatic Melanoma

(2019) Chune Yu et al.   Frontiers in Immunology

Be positive about negatives–recommendations for the publication of negative (or null) results

(2019) Anton Bespalov et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

(2018) Eszter Molnár et al.   BMC CANCER

Biological Role and Therapeutic Potential of IDH Mutations in Cancer

(2018) Matthew S. Waitkus et al.   CANCER CELL

DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells

(2018) Diannan Xu et al.   GENE

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer

(2018) François M. Vallette et al.   BIOCHEMICAL PHARMACOLOGY

Identification of regulatory role of DNA methylation in colon cancer gene expression via systematic bioinformatics analysis

(2017) Yong Yang et al.   MEDICINE

Breast ductal carcinoma in situ carry mutational driver events representative of invasive breast cancer

(2017) Jia-Min B Pang et al.   MODERN PATHOLOGY

A Braf kinase-inactive mutant induces lung adenocarcinoma

(2017) Patricia Nieto et al.   NATURE

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

(2017) Zhan Yao et al.   NATURE

Abnormal expression of mRNA, microRNA alteration and aberrant DNA methylation patterns in rectal adenocarcinoma

(2017) Yang Hua et al.   PLoS One

miR-141 promotes colon cancer cell proliferation by inhibiting MAP2K4

(2017) Lei Ding et al.   Oncology Letters

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

(2017) Mark Merchant et al.   PLoS One

Androgen-induced miR-27A acted as a tumor suppressor by targeting MAP2K4 and mediated prostate cancer progression

(2016) Xuechao Wan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

(2016) Michael Ramirez et al.   Nature Communications

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

LY3009120, a panRAF inhibitor, has significant anti-tumor activity in BRAF and KRAS mutant preclinical models of colorectal cancer

(2016) Eliza Vakana et al.   Oncotarget

Tailored Tumor Immunogenicity Reveals Regulation of CD4 and CD8 T Cell Responses against Cancer

(2016) Sarah Knocke et al.   Cell Reports

Registered report: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2016) Ajay Bhargava et al.   eLife

Registered report: Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF

(2016) Ajay Bhargava et al.   eLife

Registered report: Diverse somatic mutation patterns and pathway alterations in human cancers

(2016) Vidhu Sharma et al.   eLife

Registered report: COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2016) Vidhu Sharma et al.   eLife

Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

(2016) Babette Haven et al.   eLife

Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2016) Adam D Richarson et al.   eLife

Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors

(2015) S. R. Whittaker et al.   MOLECULAR CANCER THERAPEUTICS

Registered report: Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2015) Samrrah Raouf et al.   eLife

Registered report: Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

(2015) Brad Evans et al.   eLife

Registered report: Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2015) Denise Chroscinski et al.   eLife

Registered report: Interactions between cancer stem cells and their niche govern metastatic colonization

(2015) Francesca Incardona et al.   eLife

Conducting Meta-Analyses inRwith themetaforPackage

(2015) Wolfgang Viechtbauer   Journal of Statistical Software

Publication bias in the social sciences: Unlocking the file drawer

(2014) A. Franco et al.   SCIENCE

Registered report: Widespread potential for growth factor-driven resistance to anticancer kinase inhibitors

(2014) Edward Greenfield et al.   eLife

Registered report: Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

(2014) David Blum et al.   eLife

An open investigation of the reproducibility of cancer biology research

(2014) Timothy M Errington et al.   eLife

RAF Inhibitors Activate the MAPK Pathway by Relieving Inhibitory Autophosphorylation

(2013) Matthew Holderfield et al.   CANCER CELL

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization

(2013) Hugo Lavoie et al.   Nature Chemical Biology

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

The Sleeping Beauty transposon system: a non-viral vector for gene therapy

(2011) E. L. Aronovich et al.   HUMAN MOLECULAR GENETICS

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

(2010) Sonja J. Heidorn et al.   CELL

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

(2010) Poulikos I. Poulikakos et al.   NATURE

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

(2010) Georgia Hatzivassiliou et al.   NATURE

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Guidelines for accurate EC50/IC50 estimation

(2010) J. L. Sebaugh   PHARMACEUTICAL STATISTICS

PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells

(2010) Ruth Halaban et al.   Pigment Cell & Melanoma Research

The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner

(2010) E. W. Joseph et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA